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Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Modern Applications of Advanced Imaging to Neurological Disease

edited by Manisha Koneru and

Hamza Adel Salim

submission deadline 30 Apr 2026 | Viewed by 45 | Submission Open

Keywords: neuroimaging; cerebrovascular disease; neuro-oncology; compted tomography; magnetic resonance imaging; patient outcomes; neurosciences; neuroradiology

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

From Pathogenesis to Therapies: Innovations in Kidney Disease

edited by

Tao Qiu

Jiefu Zhu

and Chenglin Wu

submission deadline 30 Apr 2026 | Viewed by 44 | Submission Open

Keywords: renal ischemia-reperfusion injury; acute kidney injury; renal fibrosis; chronic kidney disease; ureteral obstructive nephropathy; kidney transplantation; macrophage-myofibroblast transition; inflammation; fibroblast activation; chronic allograft rejection; potential therapy

(This special issue belongs to the Section Molecular and Translational Medicine)

State-of-the-Art Drug Discovery and Development in Poland (3rd Edition)

edited by

Aleksandra Romaniuk-Drapała

submission deadline 30 Apr 2026 | Viewed by 43 | Submission Open

Keywords: in silico drug target profiling; drug delivery systems; drug– drug interaction; target-based screening; phenotypic screening; pharmaceutical modeling; computational chemistry; targeted therapy; biomarkers; bioimaging

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

New Insights into the Tumor Microenvironment: Mechanisms and Therapeutic Strategies

edited by

Denggang Fu

submission deadline 30 Apr 2026 | Viewed by 41 | Submission Open

Keywords: tumor microenvironment (TME); immune evasion; tumor– immune interaction; stromal remodeling; cancer immunotherapy; metabolic reprogramming; epigenetic regulation; multi-omics and spatial analysis; anticancer drug development

(This special issue belongs to the Section Immunology and Immunotherapy)

Heart Failure: New Diagnostic and Therapeutic Approaches, 2nd Edition

edited by

Anand Prakash Singh

submission deadline 30 Apr 2026 | Viewed by 41 | Submission Open

Keywords: heart failure; clinical treatment; basic cardiac research; future perspective; heart failure therapy; cardiotoxicity

(This special issue belongs to the Section Molecular and Translational Medicine)

Autophagy-Mediated Signalling in Cancer Metastasis and Progression

edited by

Ahmed M. Elshazly

and

David A. Gewirtz

submission deadline 30 Apr 2026 | Viewed by 39 | Submission Open

Keywords: autophagy; cancer; resistance; metastasis; tumor microenvironment; immune evasion

(This special issue belongs to the Section Cancer Biology and Oncology)

Recent Advances in Research on Neuroendocrine Neoplasms and Endocrine Sequelae After Oncological Disease

edited by Hermann L. Müller

submission deadline 30 Apr 2026 | Viewed by 37 | Submission Open

Keywords: neuroendocrine tumors; endocrinology; hormones; cancer; sequelae; late effects; neurogenic tumors

(This special issue belongs to the Section Cancer Biology and Oncology)

Immunological Barriers and Novel Therapeutic Strategies in Pediatric Brain Tumor Immunotherapy

edited by Dalia Haydar

submission deadline 30 Apr 2026 | Viewed by 34 | Submission Open

Keywords: pediatric brain tumors; diffuse intrinsic pontine glioma (DIPG); medulloblastoma; chimeric antigen receptor (CAR) T cells; blood– brain barrier (BBB); tumor microenvironment (TME); immune resistance; adoptive cell therapy; biomarkers; combination immunotherapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Diabetic Nephropathy and Diabetic Atherosclerosis (2nd Edition)

edited by

Satyesh K. Sinha

submission deadline 30 Apr 2026 | Viewed by 33 | Submission Open

Keywords: diabetic nephropathy; diabetic atherosclerosis; diabetes; inflammation; oxidative stress; renal and vascular cell dysfunction; basic science; clinical practice; patient outcomes

(This special issue belongs to the Section Molecular and Translational Medicine)

Diagnosis, Pathogenesis, Treatment and Prognosis of Glioblastoma, 2nd Edition

edited by

Paulo Linhares

submission deadline 30 Apr 2026 | Viewed by 33 | Submission Open

Keywords: glioblastoma; immunotherapy; molecular subtype; radiotherapy; molecular therapy; emerging treatment; drug resistance; MRI; immune surveillance

(This special issue belongs to the Section Cancer Biology and Oncology)

Mechanisms and Novel Therapeutic Approaches for Neurodegenerative Diseases (3rd Edition)

edited by

Fernando Cardona

submission deadline 30 Apr 2026 | Viewed by 33 | Submission Open

Keywords: neurodegenerative diseases; cellular mechanisms; molecular mechanisms; mutations; neurodegeneration models; protein misfolding; protein aggregation; neuronal death; molecular therapy; cellular therapy; therapeutics; medical chemistry; drug screening

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Alzheimer's Disease: Pathogenesis, Diagnostics and Novel Treatment Options

edited by

Rui Zhong

and Ling Li

submission deadline 30 Apr 2026 | Viewed by 31 | Submission Open

Keywords: amyloid and tau pathology; neuroinflammation and oxidative stress; neuromodulation; fluid biomarkers; imaging and other diagnostic approaches; small-molecule therapeutics; novel therapeutics and emerging therapies; disease-modifying therapies; experimental and clinical pharmacology

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Biomaterials and Nanotechnology for Advanced Wound Dressings

edited by Javad Esmaeili

submission deadline 30 Apr 2026 | Viewed by 30 | Submission Open

Keywords: wound dressings; wound healing; biomaterials and nanotechnology; regenerative medicine; targeted delivery

(This special issue belongs to the Section Nanomedicine and Nanobiology)

Nanoparticles in Biomedical Engineering: From Drug Delivery to Tissue Engineering

edited by Jia Nong

submission deadline 30 Apr 2026 | Viewed by 29 | Submission Open

Keywords: nanoparticle; nanomedicine; nanoconjugates; drug delivery; biomaterials; wound healing; angiogenesis; antimicrobial agents; regenerative medicine; theranostics

(This special issue belongs to the Section Nanomedicine and Nanobiology)

Targeting Mast Cells in Human Disease: Bridging Pathology and Therapy

edited by Marianna Criscuolo

submission deadline 30 Apr 2026 | Viewed by 29 | Submission Open

Keywords: mast cell; mast cell activation syndrome; anaphylaxis; mastocytosis; anti-mediator therapy

(This special issue belongs to the Section Immunology and Immunotherapy)

Novel Directions for Effective Treatments of Malignant Brain Tumors, Particularly Glioblastoma, Indicated by In Vivo Observations

edited by

Jacek M. Kwiecien

submission deadline 30 Apr 2026 | Viewed by 27 | Submission Open

Keywords: glioblastoma; glioblastoma cell invasion; inhibition of glioblastoma cell migration; glioblastoma cell proliferation; killing of glioblastoma cells; white matter inflammation post-neurosurgery; white matter inflammation post-irradiation; cerebral vasogenic edema; treatment of neuroinflammation and vasogenic edema; imaging of glioblastoma

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Expanding Opioid Receptor Pharmacology: From Pain Control to Novel Therapeutic Applications in Neurobiology, Immunology, and Psychiatry

edited by

Luca Gentilucci

submission deadline 30 Apr 2026 | Viewed by 27 | Submission Open

Keywords: opioid; pain; mood; stress; addiction; neuropeptides

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Innovative Therapeutic Strategies and Molecular Mechanisms in Breast Cancer

edited by

Oana Gabriela Trifanescu

and

Laurentia Nicoleta Gales

submission deadline 30 Apr 2026 | Viewed by 26 | Submission Open

Keywords: breast cancer; immunotherapy; medical imaging; biomarkers; translational research

(This special issue belongs to the Section Cancer Biology and Oncology)

Roles of Extracellular Vesicles in Health and Diseases

edited by David R. Brigstock and Xinlei Li

submission deadline 30 Apr 2026 | Viewed by 23 | Submission Open

Keywords: extracellular vesicle; exosome; pathogenesis; therapy; cancer; neurodegenerative diseases; pulmonary diseases; cardiovascular diseases; inflammatory diseases; infectious diseases; kidney diseases; gastrointestinal diseases; aging; diabetes; autoimmune disorders

(This special issue belongs to the Section Molecular and Translational Medicine)

Nanocarriers in Mucosal Drug Delivery

edited by

Hatem Hassan

submission deadline 30 Apr 2026 | Viewed by 23 | Submission Open

Keywords: nanocarriers; mucosal drug delivery; mucoadhesion; mucus penetration; controlled release; bioavailability enhancement; targeted delivery; stimuli-responsive systems

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Epilepsy: From Mechanisms to Therapeutic Approaches (2nd Edition)

edited by

Prosper N'Gouemo

submission deadline 30 Apr 2026 | Viewed by 22 | Submission Open

Keywords: genetic epilepsy; acquired epilepsy; neonatal seizures; epileptogenesis; pharmacoresistant epilepsy; ion channels; calcium signaling

(This special issue belongs to the Section Molecular and Translational Medicine)

Cancer Genetics: Bench-to-Bedside Advances

edited by

Hengrui Liu

submission deadline 30 Apr 2026 | Viewed by 22 | Submission Open

Keywords: cancer genetics; somatic mutations; biomarkers; cfDNA/ctDNA; epigenetics; tumor microenvironment; multi-omics; precision medicine

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Artificial Intelligence in Cancer Imaging: Advancing Precision Oncology

edited by Farhan Akram

submission deadline 30 Apr 2026 | Viewed by 21 | Submission Open

Keywords: artificial intelligence; cancer imaging; digital pathology; machine learning; deep learning; radiomics; tumor characterization; precision oncology; biomarker discovery; clinical translation

(This special issue belongs to the Section Cancer Biology and Oncology)

The Role of Polyamines in Human Health and Disease—Second Edition

edited by

Kuniyasu Soda

submission deadline 30 Apr 2026 | Viewed by 20 | Submission Open

Keywords: polyamine; spermidine; spermine; health; disease; development

(This special issue belongs to the Section Immunology and Immunotherapy)

Recent Advances in Cancer Metastasis Models

edited by

Lin Zhang

submission deadline 30 Apr 2026 | Viewed by 20 | Submission Open

Keywords: cancer metastasis; tumor microenvironment; metastasis models; 3D cell culture; organoids; artificial intelligence in oncology; machine learning; bioinformatics; in vivo imaging; multi-omics integration

(This special issue belongs to the Section Cancer Biology and Oncology)

Advances in Research on Spermatozoa and Male Infertility: From Molecular Mechanism to Therapeutic Perspectives

edited by

Francesca Paola Luongo

and

Alice Luddi

submission deadline 30 Apr 2026 | Viewed by 20 | Submission Open

Keywords: spermatozoa biology; molecular mechanisms of spermatogenesis; oxidative stress and sperm function; therapeutic strategies for addressing male infertility

(This special issue belongs to the Section Molecular and Translational Medicine)

Biomarker, Phenotyping and Therapeutics for Asthma

edited by

Ran Wang

submission deadline 30 Apr 2026 | Viewed by 19 | Submission Open

Keywords: allergy; biomarkers; pathogenesis; exhaled breath; multi-omics; lung physiology; phenotyping; endotypes; therapeutic targets

(This special issue belongs to the Section Molecular and Translational Medicine)

Muscular Dystrophy: From Mechanisms to Therapeutic Approaches

edited by

Gisela Gaina

and Marco A.F. Fernandes

submission deadline 30 Apr 2026 | Viewed by 18 | Submission Open

Keywords: muscular dystrophy; genetic diseases; muscle regeneration; therapeutic approaches; molecular diagnosis; in vitro and in vivo models

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Advances in Periodontal Disease and Systemic Disease

edited by Hye-Sun Shin

submission deadline 30 Apr 2026 | Viewed by 17 | Submission Open

Keywords: periodontal disease; systemic health; inflammation; oral microbiome; cardiovascular disease; diabetes; cancer; oral– gut– brain axis; precision medicine; biomarkers

(This special issue belongs to the Section Molecular and Translational Medicine)

Neuropathology: Understanding Local and Systemic Influence of Disease and Vice-Versa

edited by

Kumar Vaibhav

Pankaj Gaur

, Meenakshi Ahluwalia,

Pankaj Ahluwalia

and Shashi Nandar Kumar

submission deadline 30 Apr 2026 | Viewed by 16 | Submission Open

Keywords: brain pathologies; brain injury; Parkinson’ s disease; Alzheimer’ s disease; stroke; neurodegeneration; hemorrhages; hypoxia; neuroinflammation; translational approaches; oxidative stress; COVID-19; gut– brain axis; systemic influence; immune interaction; synaptic plasticity; ageing; senescence; bone marrow and neuropathology; pesticides; preservatives and environmental contamination; lungs and brain; liver and brain; cardiovascular effect of brain pathology and vice-versa; acute and chronic neuro-immune interaction; therapeutic strategies and intervention; alternative medicines in brain pathologies

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

New Advances in the Treatment of Brain Tumors

edited by

Harim Koo

submission deadline 30 Apr 2026 | Viewed by 9 | Submission Open

Keywords: neuro-oncology; brain tumor; cancer therapy; precision medicine; biomarkers; drug delivery; multi-omics; neurosurgery; clinical trials; bioinformatics

(This special issue belongs to the Section Cancer Biology and Oncology)

Digestive Disorders: Translation and Bridging the Gap Between Research, Diagnosis, and Treatment (2nd Edition)

edited by Goran Poropat and Goran Hauser

submission deadline 30 Apr 2026 | Viewed by 7 | Submission Open

Keywords: acute pancreatitis; clinical nutrition; metabolic disorders; NAFLD; obesity; DGBA; gut microbiota

(This special issue belongs to the Section Molecular and Translational Medicine)

New Advances in Oral Pathology and Medicine

edited by

Christian Bacci

submission deadline 30 Apr 2026 | Viewed by 6 | Submission Open

Keywords: molecular diagnostics; imaging technologies; artificial intelligence; targeted therapies; regenerative medicine

(This special issue belongs to the Section Molecular and Translational Medicine)

Photodynamic Therapy in Cancer—Second Edition

edited by

Shazia Bano

submission deadline 30 Apr 2026 | Viewed by 5 | Submission Open

Keywords: photodynamic therapy; targeted drug delivery and drug release systems; photodiagnosis/tumor imaging; PDT-induced immunogenic cell death; nanomaterials-based combination therapies; theranostics

(This special issue belongs to the Section Cancer Biology and Oncology)

Genetic Research into Human Reproduction

edited by

Efthalia Moustakli

and Athanasios Zikopoulos

submission deadline 30 Apr 2026 | Viewed by 4 | Submission Open

Keywords: reproductive genomics; assisted reproductive technologies (ARTs); reproductive endocrinology; embryo development; reproductive bioinformatics; precision fertility medicine

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

The Brain–Body Interplay in Pain, Anesthesia, and Oncology

edited by

Hui Xu

submission deadline 30 Apr 2026 | Viewed by 4 | Submission Open

Keywords: brain– body axis; neuroimmune communication; microbiome– gut– brain axis; nociception; anesthetic outcomes; cancer biology

(This special issue belongs to the Section Molecular and Translational Medicine)

Integrative Roles of Natural Products in Cancer Treatment and Chronic Inflammatory Disease

edited by

Seungho Baek

submission deadline 30 Apr 2026 | Viewed by 3 | Submission Open

Keywords: natural products; cancer; chronic inflammatory diseases; therapy; oxidative stress

(This special issue belongs to the Section Molecular and Translational Medicine)

Correlative Light and Electron Microscopy (CLEM) in Biomedicine: Advances and Applications

edited by

Hideya Kawasaki

submission deadline 30 Apr 2026 | Viewed by 2 | Submission Open

Keywords: CLEM; correlative microscopy; biomedicine; pathology; virology; oncology; immunolabeling; cryo-microscopy; ultrastructure; image analysis

(This special issue belongs to the Section Cell Biology and Pathology)

Decoding Aging with AI and Computational Modeling

edited by Bingrui Li, Xuanye Cao and Wen Jiang

submission deadline 30 Apr 2026 | Viewed by 2 | Submission Open

Keywords: aging; computational modeling; AI; healthspan and lifespan prediction; systems biology

(This special issue belongs to the Section Cell Biology and Pathology)

Rheumatic Diseases: From Pathophysiology to Current and Emerging Therapeutic Approaches

edited by Harriet Morf

submission deadline 30 Apr 2026 | Viewed by 1 | Submission Open

Keywords: rheumatic diseases; molecular mechanisms; treatment; artificial intelligence; cytokine; anti-rheumatic drugs

(This special issue belongs to the Section Immunology and Immunotherapy)

Advancements in Understanding and Treating Oral Pathologies: From Dry Mouth to Oral Cancer—2nd Edition

edited by Eleni Georgakopoulou and George Laskaris

submission deadline 30 Apr 2026 | Submission Open

Keywords: oral pathologies; oral diseases; pathogenesis; therapeutic interventions; interdisciplinary nature of oral healthcare; xerostomia; dysgeusia; oral cancer; precancerous lesions; oral inflammatory conditions

(This special issue belongs to the Section Cell Biology and Pathology)

Extracellular Vesicles: A New Frontier in Liquid Biopsy

edited by Chen Zhao and You-Ren Ji

submission deadline 30 Apr 2026 | Submission Open

Keywords: extracellular vesicles (EVs); liquid biopsy; circulating biomarkers; exosome; nanomedicine; translational oncology; precision medicine

(This special issue belongs to the Section Cell Biology and Pathology)

Animal Models in Pulmonary Research: Shaping the Future of Translational Respiratory Medicine

edited by

Badrul Hisham Yahaya

submission deadline 30 Apr 2026 | Submission Open

Keywords: pulmonary disease; lung regeneration and repair; animal models; genetically modified models; lung injury induction; translational research

(This special issue belongs to the Section Molecular and Translational Medicine)

New Perspectives on Systemic Amyloidosis: From Pathophysiology to Therapy

edited by Zoltán Pozsonyi and Katalin Révész

submission deadline 30 Apr 2026 | Submission Open

Keywords: systemic amyloidosis; cardiac amyloidosis; light chain amyloidosis; hereditary transthyretin amyloidosis; wild-type transthyretin amyloidosis; amyloidogenesis; disease-modifying treatments; heart failure with preserved ejection fraction

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Role of Oxidative Stress, Antioxidants, and Gut Microbiota in Obesity and Metabolic Disorders

edited by Lunawati Bennett

submission deadline 30 Apr 2026 | Submission Open

Keywords: obesity; metabolic diseases; antioxidants; gut microbiota; inflammation; reactive oxygen species; cardiovascular diseases

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Gynecological Cancers: Progress and Challenges

edited by

Yi-Fen Chiang

submission deadline 30 Apr 2026 | Submission Open

Keywords: gynecological cancer; therapeutic targets; precision medicine; immunotherapy; drug resistance; biomarkers; molecular mechanisms; natural compound; translational research; adjuvant therapy

(This special issue belongs to the Section Cancer Biology and Oncology)

State-of-the-Art Molecular and Translational Medicine in Poland, 3rd Edition

edited by

Małgorzata Wrzosek

and

Arkadiusz Kocur

submission deadline 31 May 2026 | 6 articles | Viewed by 17498 | Submission Open

Keywords: molecular medicine; molecular mechanisms; disease pathogenesis; genetic variants; gene expression; epigenetics; metabolic disorders; cancer

(This special issue belongs to the Section Molecular and Translational Medicine)

Advanced Cancer Diagnosis and Treatment: Third Edition

edited by

Takaaki Hirotsu

and Hideshi Ishii

submission deadline 31 May 2026 | 3 articles | Viewed by 3270 | Submission Open

Keywords: cancer biology; epigenetics; early detection; diagnosis; biodiagnosis; novel therapeutics; new paradigms

(This special issue belongs to the Section Cancer Biology and Oncology)

Molecular Regulation of Spermatozoa—Second Edition

edited by

Atefeh Najafi

submission deadline 31 May 2026 | 1 articles | Viewed by 3100 | Submission Open

Keywords: spermatogenesis; spermiogenesis; sperm; capacitation; acrosome reaction; hyperactivation; fertilization; male infertility; antioxidants; redox regulation

(This special issue belongs to the Section Cell Biology and Pathology)

Advanced Research into Adipose‐Derived Stem Cells

edited by

Anna Barbara Di Stefano

and Mara Franza

submission deadline 31 May 2026 | 1 articles | Viewed by 2634 | Submission Open

Keywords: adipose stem cells; regenerative medicine; stemness; differentiative potential; pre-clinical and clinical applications

(This special issue belongs to the Section Molecular and Translational Medicine)

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