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Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Advances in Hepatocellular Carcinoma

edited by Mohamed A. Abd El Aziz

submission deadline 16 Oct 2026 | 3 articles | Viewed by 4116 | Submission Open

Keywords: hepatocellular cancer; liver cirrhosis; chemotherapy; immunotherapy; radiofrequency ablation; microwave ablation

(This special issue belongs to the Section Cancer Biology and Oncology)

Unveiling the Genetic Architecture of Complex and Common Diseases

edited by

Mahmut Cerkez Ergoren

submission deadline 23 Oct 2026 | 4 articles | Viewed by 7433 | Submission Open

Keywords: polygenetic score; cardiovascular disorders; metabolic disorders; neurodegenerative disorders

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Research Progress on Antimicrobial Resistance (AMR)

edited by

Tomohiro Oishi

submission deadline 30 Oct 2026 | 1 articles | Viewed by 2146 | Submission Open

Keywords: antimicrobial resistance; mechanism; therapy; experiment; bacteria; antibiotics

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Biological and Targeted Therapies in Rheumatic Diseases

edited by

Georgi Kotov

and Mariana Ivanova

submission deadline 30 Oct 2026 | 1 articles | Viewed by 1280 | Submission Open

Keywords: biological disease-modifying antirheumatic drugs (bDMARDs); targeted synthetic disease-modifying antirheumatic drugs (tsDMARDs); rheumatoid arthritis; spondyloarthritis; psoriatic arthritis; systemic lupus erythematosus; scleroderma; myositis; vasculitis; pregnancy and lactation; chronic infections

(This special issue belongs to the Section Immunology and Immunotherapy)

"Small Molecule Inhibitors" in Biomedicines

edited by Sampa Gupta

submission deadline 30 Oct 2026 | 2 articles | Viewed by 1094 | Submission Open

Keywords: small molecule inhibitors (SMIs); drug discovery and development; targeted therapy; signal transduction; drug resistance; precision medicine; pharmacodynamics/pharmacokinetics

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Advances in Bone Metabolism, Bone Homeostasis and Osteogenesis

edited by

Youngjae Jeong

and Laura Ortinau

submission deadline 30 Oct 2026 | Viewed by 508 | Submission Open

Keywords: bone homeostasis and maintenance; bone remodeling; osteoblast–osteoclast interaction; endocrine signaling by bone; bone metabolic disease

(This special issue belongs to the Section Cell Biology and Pathology)

Pharmacogenomics and Drug Metabolism: From Cytochrome P450 to Emerging Enzymatic Pathways

edited by

Pradeepraj Durairaj

submission deadline 30 Oct 2026 | Viewed by 453 | Submission Open

Keywords: cytochrome P450 (CYP450); drug metabolism; xenobiotic metabolism; pharmacogenomics; biotransformation; orphan enzymes; redox biology; enzyme engineering; multi-omics approaches; personalized medicine

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Mechanisms of Cellular Senescence and Inflammation in Cardiovascular Disease

edited by Sivareddy Kotla

submission deadline 30 Oct 2026 | Viewed by 427 | Submission Open

Keywords: cellular senescence; inflammation; cardiovascular disease

(This special issue belongs to the Section Cell Biology and Pathology)

Novel Drug Delivery Systems: Design, Evaluation and Application: 2nd Edition

edited by

Yongtai Zhang

submission deadline 30 Oct 2026 | Viewed by 422 | Submission Open

Keywords: pharmaceutics; drug delivery systems; nanoparticles; nanomedicine; biomolecules; hydrogels; biomaterials

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Gut–Brain Axis in Neuropsychiatric and Neurodegenerative Disorders

edited by Felipe Leite De Oliveira

submission deadline 30 Oct 2026 | Viewed by 300 | Submission Open

Keywords: gut–brain axis; neurodevelopment; neuropsychiatric conditions; neurodegenerative diseases; neuroinflammation; behaviour; cognition; emotion

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Neurotransmitter Signaling in Central Nervous System Diseases: Mechanisms, Biomarkers and Therapeutic Targets

edited by

Luca Raiteri

submission deadline 30 Oct 2026 | Viewed by 294 | Submission Open

Keywords: central nervous system; neurotransmitters; receptors; transporters; biomarker

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Musculoskeletal Diseases: From Molecular Basis to Therapy—3rd Edition

edited by

Elisa Belluzzi

and

Assunta Pozzuoli

submission deadline 31 Oct 2026 | 19 articles | Viewed by 36619 | Submission Open

Keywords: musculoskeletal diseases; bone cancer; soft tissue cancer; bone metastasis; natural compounds; anticancer drugs; osteoarthritis; joint tissues; biomarkers; inflammation; microRNAs; exosomes

(This special issue belongs to the Section Molecular and Translational Medicine)

Saving Lives from Myocardial Infarction: Prevention vs. Therapy

edited by Dong Wang

submission deadline 31 Oct 2026 | 6 articles | Viewed by 21153 | Submission Open

Keywords: myocardial infarction; molecular markers; AI-powered early detection; wearable devices; ischemia–reperfusion injury; artificial intelligence; ventricular remodeling; fibrosis control; molecular imaging; genomics; transcriptomics; proteomics; metabolomics; MI prevention

(This special issue belongs to the Section Molecular and Translational Medicine)

Medicinal Cannabis: Advances in Therapeutics and Clinical Applications

edited by

Erin Berthold

submission deadline 31 Oct 2026 | 2 articles | Viewed by 17424 | Submission Open

Keywords: medicinal cannabis; cannabidiol (CBD); cannabigerol (CBG); cannabinoid; cannabinol (CBN)

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Pathophysiology and Therapeutic Innovations in Skin and Appendage Disorders

edited by

Xuming Zhu

submission deadline 31 Oct 2026 | 8 articles | Viewed by 17310 | Submission Open

Keywords: skin disorders; skin development; skin pathophysiology; tumorigenesis; psoriasis; atopic dermatitis; acne; innovative therapies; molecular dermatology; translational skin research

(This special issue belongs to the Section Cell Biology and Pathology)

Urticaria: New Insights into Pathogenesis, Diagnosis and Therapy

edited by

Angela Rizzi

submission deadline 31 Oct 2026 | 4 articles | Viewed by 14944 | Submission Open

Keywords: acute urticaria; chronic urticaria; pathogenesis; mast cells; biomarkers; diagnosis; biologicals

(This special issue belongs to the Section Molecular and Translational Medicine)

State-of-the-Art Endocrine Cancer Biology and Oncology

edited by

Piotr Glinicki

submission deadline 31 Oct 2026 | 7 articles | Viewed by 13494 | Submission Open

Keywords: thyroid and parathyroid tumors; adrenal tumors (hormonally active and inactive, ACC); neuroendocrine tumors (NEN); pituitary neuroendocrine tumors (PiNETs)

(This special issue belongs to the Section Cancer Biology and Oncology)

Neurodegenerative Diseases: From Mechanisms to Therapeutic Approaches, 2nd Edition

edited by

Marie-Lise Maddelein

submission deadline 31 Oct 2026 | 6 articles | Viewed by 11413 | Submission Open

Keywords: neurodegenerative diseases; neurons; mechanism

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Navigating the Complex Landscape of Non-Communicable Respiratory Diseases: Emerging Challenges and Opportunities

edited by

Katya Rigatto

submission deadline 31 Oct 2026 | 6 articles | Viewed by 10182 | Submission Open

Keywords: non-communicable respiratory diseases; asthma; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease

(This special issue belongs to the Section Molecular and Translational Medicine)

Molecular and Cellular Mechanisms of Cardiovascular Diseases: 2nd Edition

edited by

Antonella Galeone

submission deadline 31 Oct 2026 | 5 articles | Viewed by 10152 | Submission Open

Keywords: hypertension; diabetes; coronary heart disease; valvular heart disease; infective endocarditis; aortic dissection; aortic aneurysm; heart failure; cardiomyopathy

(This special issue belongs to the Section Molecular and Translational Medicine)

Cannabinoids in Therapeutics: Mechanisms, Signaling Pathways and Personalized Treatment Strategies

edited by

Jan Rožanc

and

Uroš Maver

submission deadline 31 Oct 2026 | 6 articles | Viewed by 9403 | Submission Open

Keywords: cannabinoids; endocannabinoid system; cancer; pain; inflammation; personalized medicine; receptor signaling; therapeutic development; drug delivery; pharmacogenomics; systems pharmacology

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Type 2 Diabetes: Current Progress and Future Challenges

edited by

Tomislav Kurevija

submission deadline 31 Oct 2026 | 5 articles | Viewed by 9365 | Submission Open

Keywords: type 2 diabetes; cardiovascular risk; novel antidiabetics; clinical guidelines therapeutic inertia; obesity; insulin resistance; metabolic syndrome; diabetology; family medicine

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Recent Advances in Adipokines (3nd Edition)

edited by

Christa Büchler

submission deadline 31 Oct 2026 | 9 articles | Viewed by 8762 | Submission Open

Keywords: adiponectin; receptor; agonist; biomarker; inflammation; cancer

(This special issue belongs to the Section Cell Biology and Pathology)

Innovations and Perspectives in Kidney Transplantation

edited by Vassilis Filiopoulos

submission deadline 31 Oct 2026 | 5 articles | Viewed by 8731 | Submission Open

Keywords: bioartificial kidney; immunology; immunosuppression; kidney transplantation; tolerance; graft rejection; graft survival; xenotransplantation; kidney regeneration

(This special issue belongs to the Section Immunology and Immunotherapy)

Biomarkers in Metabolic Disorders, Obesity and Type 2 Diabetes Mellitus—2nd Edition

edited by

Maciej Walędziak

and Anna Maria Różańska-Walędziak

submission deadline 31 Oct 2026 | 6 articles | Viewed by 8400 | Submission Open

Keywords: metabolic disorders; obesity; type 2 diabetes mellitus; bariatric surgery; laboratory parameters

(This special issue belongs to the Section Endocrinology and Metabolism Research)

The Role of Ion Channels and Transporters in Human Health and Diseases (2nd Edition)

edited by Teresa Soda

submission deadline 31 Oct 2026 | 2 articles | Viewed by 8329 | Submission Open

Keywords: ion channels; transporters; ion pumps; voltage-gated channels; ionotropic receptors; TRP channels; store-operated channels; piezo channels; NALCN channels; inositol-1,4,5-receptors; ryanodine receptors; two-pore channels; synaptic transmission; channelopathies; neurodegenerative disorders; cardiovascular disorders

(This special issue belongs to the Section Molecular and Translational Medicine)

Kidney Diseases in Critical Ill Patients

edited by

Caterina Carollo

submission deadline 31 Oct 2026 | 2 articles | Viewed by 8089 | Submission Open

Keywords: acute kidney disease; critical care; beside diagnostics; point of care ultrasounds; dialysis

(This special issue belongs to the Section Molecular and Translational Medicine)

Neuroimmunology and Neurological Infection

edited by

Mariya Ivanovska

submission deadline 31 Oct 2026 | 3 articles | Viewed by 7824 | Submission Open

Keywords: neuroimmunology; neurological infections; immune-mediated diseases; neurodegeneration; biomarkers; immunotherapy; neuroinflammation; clinical neurology

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Chronic Pain: From Prevention to Therapeutic Strategies—Third Edition

edited by Isaura Tavares and

Daniel Humberto Pozza

submission deadline 31 Oct 2026 | 4 articles | Viewed by 7809 | Submission Open

Keywords: pain pathophysiology; pain prevention; predictive sensory testing; pre- and postoperative chronic pain; new biomarkers in pain; pain management and novel treatments; preemptive analgesia; inflammatory pain

(This special issue belongs to the Section Molecular and Translational Medicine)

Multidisciplinary Approaches to Neurodegenerative Disorders

edited by

Toomas Toomsoo

submission deadline 31 Oct 2026 | 3 articles | Viewed by 7346 | Submission Open

Keywords: neurodegenerative disorders; lipid metabolism; comorbidity patterns super-agers; precision medicine; biomarker discovery; AI-assisted diagnostics; translational neuroscience; multi-omics integration; neuroinflammation

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Obesity-Related Gastrointestinal Disorders: Uncovering Mechanisms Behind Cardiometabolic Improvement with Weight Loss

edited by

Wissam Ghusn

submission deadline 31 Oct 2026 | 2 articles | Viewed by 6901 | Submission Open

Keywords: metabolic dysfunction-associated steatotic liver disease (MASLD); gastro-esophageal reflux disease (GERD); obesity; cardiometabolic comorbidities; type 2 diabetes; hypertension; gut hormones; gastrointestinal function

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Human Stem Cells in Disease Modelling and Treatment (2nd Edition)

edited by Sofia M. Calado and

Álvaro Plaza Reyes

submission deadline 31 Oct 2026 | 5 articles | Viewed by 6619 | Submission Open

Keywords: induced pluripotent stem cells (iPSCs); embryonic stem cells (ESCs); disease models; cell therapies; cell therapy medicinal products (CTMPs); regenerative medicine

(This special issue belongs to the Section Biomedical Engineering and Materials)

Emerging Technologies in Liquid Biopsy of Cancers

edited by Lingdi Yin

submission deadline 31 Oct 2026 | 2 articles | Viewed by 6612 | Submission Open

Keywords: liquid biopsy; circulating tumor cells (CTCs); circulating tumor DNA (ctDNA); exosomes; cancer diagnostics; biomarker discovery; minimally invasive monitoring; emerging technologies; clinical translation; molecular profiling

(This special issue belongs to the Section Cancer Biology and Oncology)

Neurovascular Dysfunction: Mechanisms and Therapeutic Strategies

edited by

Deepti Diwan

submission deadline 31 Oct 2026 | 3 articles | Viewed by 6539 | Submission Open

Keywords: neurovascular; blood vessels; nervous system; neurological diseases

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Aortic Aneurysm: Mechanisms, Biomarkers, and Therapeutic Strategy

edited by

Mitra Esfandiarei

and

Seda Selamet Tierney

submission deadline 31 Oct 2026 | 6 articles | Viewed by 6334 | Submission Open

Keywords: aortic aneurysms; genetic aortic diseases; endothelial dysfunction; extracellular matrix; aortic wall; aortic smooth muscle; angiotensin system; aortic wall elasticity; matrix metalloproteinases

(This special issue belongs to the Section Molecular and Translational Medicine)

Mycobacterial Infections: Insights into Pathogenesis, Diagnosis, and Treatment

edited by

Abhishek Mishra

submission deadline 31 Oct 2026 | 3 articles | Viewed by 6222 | Submission Open

Keywords: mycobacterium; pathogenesis; host–pathogen interactions; virulence factors; antimicrobial resistance; diagnosis; therapeutics; host-directed therapy; vaccine development; drug resistance

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Fertility and Reproductive Health: Understanding of Reproductive Physiology and Pathology

edited by Sevastiani Antonouli and

Valentina Di Nisio

submission deadline 31 Oct 2026 | 4 articles | Viewed by 6167 | Submission Open

Keywords: female infertility; male infertility; oocyte quality; embryo implantation; follicular dynamics; gamete and embryo ultrastructure; assisted reproduction technologies; reproductive aging; fertility preservation; oncofertility challenges

(This special issue belongs to the Section Gene and Cell Therapy)

Advances in Single-Cell and Spatial Transcriptomics: Decoding Tumor Heterogeneity and Microenvironment

edited by

Guanhu Yang

submission deadline 31 Oct 2026 | 3 articles | Viewed by 5855 | Submission Open

Keywords: single-cell sequencing; spatial transcriptomics; tumor microenvironment; heterogeneity; immunotherapy resistance

(This special issue belongs to the Section Cancer Biology and Oncology)

New Insights into the Diagnosis and Treatment of Hepatocellular Carcinoma—2nd Edition

edited by

Evangelos Koustas

submission deadline 31 Oct 2026 | 1 articles | Viewed by 5843 | Submission Open

Keywords: checkpoint inhibitors; combinatorial treatments; hepatocellular carcinoma (HCC); immunotherapy; liver cancer; therapy; targeted therapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Biomarker, Phenotyping and Therapeutics for Asthma

edited by

Ran Wang

submission deadline 31 Oct 2026 | 6 articles | Viewed by 4847 | Submission Open

Keywords: allergy; biomarkers; pathogenesis; exhaled breath; multi-omics; lung physiology; phenotyping; endotypes; therapeutic targets

(This special issue belongs to the Section Molecular and Translational Medicine)

Multisystem Crosstalk in Health and Disease

edited by

Mehmet Bostancıklıoğlu

submission deadline 31 Oct 2026 | 1 articles | Viewed by 4838 | Submission Open

Keywords: systems biology; immunometabolism; inflammation; integrative physiology; molecular pathways; translational research; multi-omics; chronic disease; host–microbe interactions; metabolic regulation

(This special issue belongs to the Section Endocrinology and Metabolism Research)

New Trends in Regional Anesthesia and Pain Management

edited by

Jui-An Lin

submission deadline 31 Oct 2026 | 3 articles | Viewed by 4791 | Submission Open

Keywords: regional anesthesia; ultrasound-guided/stimulator-guided nerve blocks; novel techniques for motor-sparing neural intervention; continuous catheter infusions; opioid-sparing techniques; perioperative pain management; novel local anesthetics; cadaveric dissection exploring the anatomical knowledge of motor-sparing techniques; modalities (techniques, technologies, or drug regimen) to prolong the effect of local anesthetics; ERAS-related studies; AI applications in regional anesthesia and pain management; innovations and protocols/curriculum regarding regional anesthesia and pain management in the battlefield; studies comparing new technologies/simulation (such as EpiFaith, SPRint PNS system, or CompuFlo) with traditional methods in improving regional anesthesia and pain management; regenerative medicine; nutritional pain medicine; application of bone marrow aspirate concentration or other stem cell components in pain medicine; multidisciplinary/comprehensive care program; transarterial embolization for pain management; joint denervation for pain management

(This special issue belongs to the Section Molecular and Translational Medicine)

Chronic Liver Disease: From Mechanisms to Therapeutic Approaches

edited by

Xuefeng Luo

submission deadline 31 Oct 2026 | 2 articles | Viewed by 4571 | Submission Open

Keywords: chronic liver disease; cirrhosis; portal hypertension; hepatocellular carcinoma; variceal bleeding; transjugular intrahepatic portosystemic shunt (TIPS)

(This special issue belongs to the Section Molecular and Translational Medicine)

Nervous System Injury and Repair: From Molecular Mechanism to Therapeutic Perspectives

edited by

Shuchao Wang

submission deadline 31 Oct 2026 | 2 articles | Viewed by 3603 | Submission Open

Keywords: nervous system injury; neuron; astrocytes; microglial cells; excitotoxicity; inflammation; oxidative stress; neuroprotection

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Recent Advanced Research in Hypertension

edited by Rodrigo Maranon

submission deadline 31 Oct 2026 | 1 articles | Viewed by 3551 | Submission Open

Keywords: hypertension; sex differences; pathophysiology; precision medicine; novel therapeutics; digital health; cardiovascular disease

(This special issue belongs to the Section Cell Biology and Pathology)

New Insights in Immunological Pathways

edited by

Wan-Chung Hu

submission deadline 31 Oct 2026 | 2 articles | Viewed by 3108 | Submission Open

Keywords: immune response; immune signal pathway; cytokine storm

(This special issue belongs to the Section Immunology and Immunotherapy)

Lymphomas: From Mechanisms to Therapeutic Approaches

edited by Delfa Radić-Krišto and

Vibor Milunović

submission deadline 31 Oct 2026 | 2 articles | Viewed by 3057 | Submission Open

Keywords: aggressive lymphomas; cellular therapy; cellular immunotherapy; translational medicine; lymphomagenesis; indolent lymphomas; phase I/II clinical trials; targeted therapy; biomarkers; in vitro and in vivo models of lymphomas

(This special issue belongs to the Section Cancer Biology and Oncology)

Oxidative Stress, Mitochondrial Dysfunction, and Aβ Pathology: Converging Pathways in Aging and Neurodegeneration

edited by

Swapnil Pandey

, Laxmi Rathor and

Ashish Shukla

submission deadline 31 Oct 2026 | 1 articles | Viewed by 2912 | Submission Open

Keywords: oxidative stress; aging; amyloid beta; tau phosphorylation; neurodegeneration; regulated cell death; mitochondrial biogenesis; Drosophila; C. elegans

(This special issue belongs to the Section Cell Biology and Pathology)

Progress in Cytotoxicity of Biomaterials

edited by Lakkamraju Vijayalakshmi

submission deadline 31 Oct 2026 | 1 articles | Viewed by 2820 | Submission Open

Keywords: biomaterial cytotoxicity; biocompatibility assessment; in vitro and in vivo toxicity; surface modification; nanomaterials in medicine; oxidative stress and inflammation; tissue engineering materials; drug delivery systems; biodegradable polymers; regulatory perspectives on biomaterial safety

(This special issue belongs to the Section Biomedical Engineering and Materials)

Advances in Immunometabolism: Molecular Pathways, Regulatory Networks, and Therapeutic Opportunities

edited by

Sebastian Mertowski

submission deadline 31 Oct 2026 | 2 articles | Viewed by 2812 | Submission Open

Keywords: immunometabolism; metabolic reprogramming; immune-cell signaling; inflammation; tumor microenvironment; mitochondrial dysfunction; oxidative stress; immunometabolic checkpoints; biomarkers; targeted therapy

(This special issue belongs to the Section Immunology and Immunotherapy)

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