Research Progress on Antimicrobial Resistance (AMR)

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Drug Discovery, Development and Delivery".

Deadline for manuscript submissions: 30 October 2026 | Viewed by 1371

Special Issue Editor


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Guest Editor
Department of Clinical Infectious Diseases, Kawasaki Medical School, Okayama 701-0192, Japan
Interests: antibiotic resistance mechanisms; multidrug-resistant bacterial infections; strategies for antibiotic resistant bacterial infections
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Special Issue Information

Dear Colleagues,

Antimicrobial resistance (AMR) is currently a global concern. During the COVID-19 pandemic, infectious disease specialists focused on the prevention and control of COVID-19, and strict infection control served to restrict the spread of endemic infectious diseases. However, following COVID-19, many endemic infectious diseases emerged again, and several cases of antimicrobial resistance have been reported. For example, carbapenem-resistant Enterobacteriaceae (CRE) infections have been increasing, and drug therapy is currently limited. Therefore, identifying AMR pathogens is of paramount importance. In addition to severe and hospitalized infections such as CRE, community-acquired infections such as Mycoplasma pneumoniae infections and pertussis have also increased, along with macrolide-resistant isolates. Hence, this Special Issue addresses the increasing prevalence of antimicrobial resistance infections, highlights their current therapies, and identifies future challenges. We welcome research on all aspects of AMR, including the mechanism of resistance and therapeutic strategies.

Prof. Dr. Tomohiro Oishi
Guest Editor

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Keywords

  • antimicrobial resistance
  • mechanism
  • therapy
  • experiment
  • bacteria
  • antibiotics

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Published Papers (1 paper)

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Research

8 pages, 425 KB  
Communication
Analysis of Macrolide Resistance in Bordetella pertussis Isolated from Japanese Children in 2025 Using Test Kit and Sequence Method
by Tomohiro Oishi and Takashi Nakano
Biomedicines 2026, 14(1), 167; https://doi.org/10.3390/biomedicines14010167 - 13 Jan 2026
Viewed by 939
Abstract
Background: Bordetella pertussis causes pertussis, a respiratory infection with whooping cough. Despite a high vaccine coverage, pertussis resurged post-COVID-19 pandemic. Meanwhile, isolates resistant to macrolides—the first-line therapy—have increased in several countries, including Japan. Culturing B. pertussis and detecting resistance are difficult; reports [...] Read more.
Background: Bordetella pertussis causes pertussis, a respiratory infection with whooping cough. Despite a high vaccine coverage, pertussis resurged post-COVID-19 pandemic. Meanwhile, isolates resistant to macrolides—the first-line therapy—have increased in several countries, including Japan. Culturing B. pertussis and detecting resistance are difficult; reports remain limited in Japan. Methods: From March to August 2025, we collected nasopharyngeal samples from children aged 0–15 years with suspected pertussis at six Japanese clinics. Pediatricians obtained swabs and tested them using gene-amplification kits (e.g., BioFire® SpotFire® in four clinics, LAMP Pertussis Detection® in two clinics). B. pertussis was confirmed by PCR; isolates were sequenced to identify macrolide-resistant mutations. Results: Samples were taken from 54 children, the number of boys and girls was 34 and 20, and their median age was 12 years old. Among 54 B. pertussis isolates, 43/52 (82.7%) sequenced strains harbored the A2047G mutation associated with macrolide resistance. Resistance rates at each clinic varied from 40% to 96%. Conclusions: These findings indicate a post-pandemic rise in macrolide-resistant B. pertussis in Japan. Ongoing resistance surveillance is essential, and repurposing residual clinical samples after routine testing is useful given culture and detection challenges. Full article
(This article belongs to the Special Issue Research Progress on Antimicrobial Resistance (AMR))
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