"Small Molecule Inhibitors" in Biomedicines

Dear Colleagues,

Despite the rise of biologics, small molecule inhibitors (SMIs) remain the cornerstone of precision medicine due to their oral bioavailability, ability to penetrate cell membranes, and diverse chemical space. However, challenges such as off-target toxicity, acquired drug resistance, and the pursuit of "undruggable" targets (e.g., transcription factors and protein–protein interactions) continue to drive innovation. The aim of this Special Issue is to consolidate cutting-edge research on the design, development, and therapeutic validation of novel SMIs. We welcome original research and comprehensive reviews that explore the following: Novel chemical scaffolds and structure–activity relationship (SAR) studies; advancements in AI-driven drug discovery for SMIs; mechanisms of resistance and strategies to restore sensitivity (e.g., combination therapies); and translational studies on the role of SMIs in oncology, neurodegeneration, and inflammatory diseases. The key objective of this Special Issue, by bridging basic molecular biology with clinical outcomes, is to highlight how SMIs are evolving to meet modern medical challenges.

Dr. Sampa Gupta
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the Special Issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.