Special Issues

Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Microbiota and Immunity in Cancers
edited by Frumento Davide
submission deadline 31 Jan 2026 | Viewed by 12 | Submission Open
Keywords: immunology; cancer; microbiota; immunotherapy; probiotics; oncology
(This special issue belongs to the Section Molecular and Translational Medicine)
Innovations in Understanding and Treating Pancreatic Diseases
edited by
submission deadline 31 Jan 2026 | Viewed by 8 | Submission Open
Keywords: pancreatic cancer; pancreatitis; tumor microenvironment; epithelial– mesenchymal transition (EMT); metastasis; liver metastatic niche; immunotherapy; biomarkers; targeted therapies; inflammation and fibrosis
(This special issue belongs to the Section Cell Biology and Pathology)
Advances in Cancer Cell Metabolism and Tumor Microenvironment
edited by
submission deadline 31 Jan 2026 | Submission Open
Keywords: metabolism; cancer; immune cells; tumor microenvironment; cancer-associated organ failure; cancer therapeutics
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Innovations in Bone and Craniofacial Tissue Engineering: From Biomaterials and Mechanobiology to Clinical Applications
edited by Zhekai Hu
submission deadline 15 Feb 2026 | Viewed by 61 | Submission Open
Keywords: bone tissue engineering; craniofacial regeneration; biomaterials and scaffolds; stem cells and exosomes; mechanobiology and orthodontic forces; osteoimmunology; oxidative stress modulation; gene/drug delivery; translational research; periodontal and alveolar bone regeneration
(This special issue belongs to the Section Biomedical Engineering and Materials)
Autophagic Signatures in Health and Disease: Molecular Insights and Clinical Applications submission deadline 20 Feb 2026 | Viewed by 19 | Submission Open
Keywords: autophagy; pathology; physiology; therapy; methods
(This special issue belongs to the Section Cell Biology and Pathology)
Obstructive Sleep Apnea: Mechanisms, Comorbidities, and Optimization of Emerging and Established Therapies submission deadline 25 Feb 2026 | 1 articles | Viewed by 643 | Submission Open
Keywords: obstructive sleep apnea; sleep-disordered breathing; pathophysiology; cardiometabolic comorbidities; precision medicine; CPAP; sleep diagnostics; biomarkers; neurocognitive impairment; new therapies
(This special issue belongs to the Section Molecular and Translational Medicine)
Pathology, Complications and Prognosis of Type 1 Diabetes
edited by Maurizio Delvecchio
submission deadline 27 Feb 2026 | Viewed by 15 | Submission Open
Keywords: type 1 diabetes mellitus; autoimmune β -cell destruction; diabetic complications; microvascular and macrovascular damage; diabetic ketoacidosis; glycemic control; disease prognosis; immunopathogenesis
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Cellular and Pathogenesis Mechanisms in Oral Cancer
edited by
submission deadline 28 Feb 2026 | 4 articles | Viewed by 11368 | Submission Open
Keywords: oral carcinogenesis; oral cancer model; OSCC; oral cytology; biomarkers; targeted therapies; precision medicine; bioinformatics
(This special issue belongs to the Section Molecular and Translational Medicine)
Glioblastoma: Pathogenetic, Diagnostic and Therapeutic Perspectives submission deadline 28 Feb 2026 | 5 articles | Viewed by 10706 | Submission Open
Keywords: drug delivery methods (TTFields; nanoparticles); immunotherapy; oncolytic virotherapy; cell metabolism (glycolysis; OXPHOS; fatty acid oxidation); epigenetic; biomarkers; gene therapy (CRISPR/Cas9)
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Feature Reviews in Mesenchymal Stem Cells submission deadline 28 Feb 2026 | 2 articles | Viewed by 3434 | Submission Open
Keywords: mesenchymal stem cells; tissue repair and regeneration; immunomodulatory functions
(This special issue belongs to the Section Cell Biology and Pathology)
Progress in Nanotechnology-Based Therapeutic Strategies
edited by Ambra Del Grosso and Mariacristina Gagliardi
submission deadline 28 Feb 2026 | 3 articles | Viewed by 3123 | Submission Open
Keywords: nanotechnology-based therapies; targeted drug delivery; nanoparticles; nanostructures; cancer treatment; cardiovascular diseases; neurodegenerative diseases; infectious diseases; lysosomal storage disorders; regenerative medicine; tissue engineering; gene therapy; biochemical diagnostics; omics approaches; biological barriers
(This special issue belongs to the Section Nanomedicine and Nanobiology)
Kidney Diseases in Critical Ill Patients
edited by
submission deadline 28 Feb 2026 | 1 articles | Viewed by 1998 | Submission Open
Keywords: acute kidney disease; critical care; beside diagnostics; point of care ultrasounds; dialysis
(This special issue belongs to the Section Molecular and Translational Medicine)
Endothelial Dysfunction: From a Pathophysiological Mechanism to a Potential Therapeutic Target—3rd Edition submission deadline 28 Feb 2026 | 1 articles | Viewed by 1982 | Submission Open
Keywords: endothelial function; arterial stiffness; vascular medicine; cardiovascular risk; nitric oxide; reactive oxygen species; interleukins; inflammation; biomarkers
(This special issue belongs to the Section Cell Biology and Pathology)
Advanced Research in Breast Diseases and Histopathology
edited by Michał Budzik
submission deadline 28 Feb 2026 | 1 articles | Viewed by 1694 | Submission Open
Keywords: breast cancer; breast diseases; histopathology; biomarkers; screening; diagnosis; early detection; tumor microenvironment; pathophysiology; molecular biology
(This special issue belongs to the Section Cell Biology and Pathology)
Pathogenesis and Treatment of Mycobacterium Tuberculosis Infection
edited by Sajid Nadeem
submission deadline 28 Feb 2026 | 1 articles | Viewed by 1359 | Submission Open
Keywords: mycobacterium tuberculosis; pathogenesis; host-directed therapy; inflammation; necrosis; innate and adaptive immunity
(This special issue belongs to the Section Microbiology in Human Health and Disease)
Molecular Research in Ocular Pathology submission deadline 28 Feb 2026 | 2 articles | Viewed by 1121 | Submission Open
Keywords: molecular pathology; ocular diseases; biomarkers; diabetic retinopathy; glaucoma; age-related macular degeneration; thyroid eye disease; inflammatory pathways; oxidative stress; angiogenesis; neurodegeneration; gene therapy; cell therapy; precision medicine; ocular imaging
(This special issue belongs to the Section Molecular and Translational Medicine)
Congenital Heart Disease: Diagnosis, Treatment and Prognosis
edited by
submission deadline 28 Feb 2026 | 1 articles | Viewed by 1035 | Submission Open
Keywords: adult congenital heart disease; eisenmenger's syndrome; endocarditis; thromboprophylaxis
(This special issue belongs to the Section Molecular and Translational Medicine)
Recent Advances in Oral Medicine—2nd Edition submission deadline 28 Feb 2026 | 1 articles | Viewed by 639 | Submission Open
Keywords: oral medicine; oral manifestations of systemic conditions; drug-induced lesions; oral pathologies; head and neck cancer; autoimmune; oral lesions; bisphosphonates; systemic pharmacotherapy; infectious diseases
(This special issue belongs to the Section Molecular and Translational Medicine)
Pluripotent Stem Cells: Current Understanding and Future Directions—2nd Edition submission deadline 28 Feb 2026 | Viewed by 608 | Submission Open
Keywords: induced pluripotent stem cells; iPSC generation; somatic reprogramming; iPSC-derived cells; cell therapy; exosome therapy; therapeutic application; drug screening
(This special issue belongs to the Section Cell Biology and Pathology)
Multisystem Crosstalk in Health and Disease submission deadline 28 Feb 2026 | Viewed by 465 | Submission Open
Keywords: systems biology; immunometabolism; inflammation; integrative physiology; molecular pathways; translational research; multi-omics; chronic disease; host– microbe interactions; metabolic regulation
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Recent Advances in Primary and Relapsed Ovarian Cancer
edited by Cornelia Bachmann
submission deadline 28 Feb 2026 | Viewed by 322 | Submission Open
Keywords: ovarian cancer; relapse; BRCA; genetics; immunotherapy; biomarkers
(This special issue belongs to the Section Cancer Biology and Oncology)
Demyelinating Diseases: Pathophysiology and Emerging Therapeutic Targets
edited by Jude Taylor
submission deadline 28 Feb 2026 | Viewed by 252 | Submission Open
Keywords: demyelinating diseases; pathophysiological processes; diagnostic accuracy and predicting disease; emerging strategies
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Pathophysiology and Therapeutic Innovations in Skin and Appendage Disorders
edited by
submission deadline 28 Feb 2026 | Viewed by 104 | Submission Open
Keywords: skin disorders; skin development; skin pathophysiology; tumorigenesis; psoriasis; atopic dermatitis; acne; innovative therapies; molecular dermatology; translational skin research
(This special issue belongs to the Section Cell Biology and Pathology)
Novel Insight into Human Reproductive Medicines
edited by
submission deadline 28 Feb 2026 | Viewed by 80 | Submission Open
Keywords: IVF; oocyte; sperm; clinical outcome; embryo; ovulation induction; fertilization; PGT
(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)
Nervous System Injury and Repair: From Molecular Mechanism to Therapeutic Perspectives
edited by
submission deadline 28 Feb 2026 | Viewed by 78 | Submission Open
Keywords: nervous system injury; neuron; astrocytes; microglial cells; excitotoxicity; inflammation; oxidative stress; neuroprotection
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Cannabinoids in Therapeutics: Mechanisms, Signaling Pathways and Personalized Treatment Strategies
edited by and
submission deadline 28 Feb 2026 | Viewed by 56 | Submission Open
Keywords: cannabinoids; endocannabinoid system; cancer; pain; inflammation; personalized medicine; receptor signaling; therapeutic development; drug delivery; pharmacogenomics; systems pharmacology
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Advances in Cancer Treatment submission deadline 28 Feb 2026 | Viewed by 52 | Submission Open
Keywords: targeted therapy; bio-conjugates; biologic agents; precision oncology; personalized cancer treatment; biomarker-guided therapy; cancer drug development; biopharmaceuticals
(This special issue belongs to the Section Cancer Biology and Oncology)
Growth Hormone Disorders and Their Related Diseases: From Pathophysiology to Therapeutic Approaches
edited by
submission deadline 28 Feb 2026 | Viewed by 49 | Submission Open
Keywords: growth; growth hormone deficiency; GH; IGF-1; pediatric endocrinology
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Liver Cancer: Molecular and Translational Insights of Carcinogenesis and Treatments
edited by
submission deadline 28 Feb 2026 | Viewed by 43 | Submission Open
Keywords: liver cancer; hepatocellular carcinoma; intrahepatic cholangiocarcinoma; carcinogenesis; premalignant lesions; diagnosis; pathology; treatment
(This special issue belongs to the Section Cancer Biology and Oncology)
Human Stem Cells in Disease Modelling and Treatment (2nd Edition)
edited by Sofia M. Calado and
submission deadline 28 Feb 2026 | Viewed by 42 | Submission Open
Keywords: induced pluripotent stem cells (iPSCs); embryonic stem cells (ESCs); disease models; cell therapies; cell therapy medicinal products (CTMPs); regenerative medicine
(This special issue belongs to the Section Biomedical Engineering and Materials)
Multidisciplinary Approaches to Neurodegenerative Disorders
edited by
submission deadline 28 Feb 2026 | Viewed by 39 | Submission Open
Keywords: neurodegenerative disorders; lipid metabolism; comorbidity patterns super-agers; precision medicine; biomarker discovery; AI-assisted diagnostics; translational neuroscience; multi-omics integration; neuroinflammation
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Eicosanoids and Fatty Acids in Health, Diseases and Therapeutics
edited by Mihai Nechifor
submission deadline 28 Feb 2026 | Viewed by 38 | Submission Open
Keywords: eicosanoids; prostaglandins; leukotrienes; prostacyclin; lipoxins; resolvins; protectins; maresins; arachidonic acid (AA); eicosapentaenoic acid (EPA); docosahexaenoic acid (DHA); cell functions; immunity; cardiovascular; neuropsychiatric; metabolic; digestive; reproductive; hematologic; inflammatory and oncologic pathology; therapeutics
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Innovative Strategies for the Diagnosis and Treatment of Sarcopenia and Osteoporosis
edited by Wei-Bin Hsu and
submission deadline 28 Feb 2026 | Viewed by 37 | Submission Open
Keywords: sarcopenia; osteoporosis; healthy aging; bone strength; muscle health; fracture prevention; pharmacological therapies; nutritional support; exercise rehabilitation
(This special issue belongs to the Section Molecular and Translational Medicine)
Current Challenges and Future Trends in Intracranial Aneurysms: Mechanisms, Biomarkers, and Therapeutic Strategies
edited by Zhongsong Shi and
submission deadline 28 Feb 2026 | Viewed by 35 | Submission Open
Keywords: intracranial aneurysm; subarachnoid hemorrhage; inflammation; immune; smooth muscle cell; endothelial dysfunction; hemodynamic forces; biomarkers; neuroimaging; non-coding RNA; multi-omics; endovascular treatment; computational fluid dynamic
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Immune and Metabolic Dysregulation in Neurological and Neuropsychiatric Disorders
edited by and
submission deadline 28 Feb 2026 | Viewed by 34 | Submission Open
Keywords: neuroimmune interaction; neuroinflammation; metabolic regulation; gut– brain axis; microbiome; neuroendocrine system; neurodegeneration; psychiatric disorders; brain injuries
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Diabetes: Comorbidities, Therapeutics and Insights (3rd Edition)
edited by
submission deadline 28 Feb 2026 | Viewed by 33 | Submission Open
Keywords: diabetes; complications; diabetic retinopathy; diabetic neuropathy; diabetic nephropathy; biomarkers
(This special issue belongs to the Section Molecular and Translational Medicine)
Advances in Single-Cell and Spatial Transcriptomics: Decoding Tumor Heterogeneity and Microenvironment
edited by
submission deadline 28 Feb 2026 | Viewed by 33 | Submission Open
Keywords: single-cell sequencing; spatial transcriptomics; tumor microenvironment; heterogeneity; immunotherapy resistance
(This special issue belongs to the Section Cancer Biology and Oncology)
Molecular Diagnostics in Diabetes: From Biomarkers to Clinical Applications
edited by and Konrad Walczak
submission deadline 28 Feb 2026 | Viewed by 29 | Submission Open
Keywords: diabetes; molecular diagnostics; cell-free DNA (cfDNA); microRNAs; circulating biomarkers; diabetes complications; personalized therapy
(This special issue belongs to the Section Cell Biology and Pathology)
Immune Cell Reprogramming: Molecular Mechanisms and Therapeutic Approaches
edited by , and Paolo Convertini
submission deadline 28 Feb 2026 | Viewed by 29 | Submission Open
Keywords: immune cell reprogramming; immunometabolism; macrophage activation; gene expression regulation; cell signaling; innate immunity; adaptive immunity; metabolic disorders; chronic inflammation; targeted therapies
(This special issue belongs to the Section Immunology and Immunotherapy)
Neurotrauma: Mechanisms, Pathways, and Emerging Therapeutic Interventions, 2nd Edition
edited by Kevin Pierre and
submission deadline 28 Feb 2026 | Viewed by 29 | Submission Open
Keywords: neurotrauma; traumatic brain injury; spinal cord injury; inflammation; oxidative stress; excitotoxicity; diagnostic biomarkers; imaging techniques; neuroprotection; neurogeneration
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Anti-Cancer Agents: Synthesis and Evaluation of Pharmacological Activity
edited by Sureshbabu Popuri
submission deadline 28 Feb 2026 | Viewed by 24 | Submission Open
Keywords: anticancer agents; synthesis; pharmacological evaluation; medicinal chemistry; small molecules; metal complexes; structure– activity relationship (SAR); cytotoxic activity; apoptosis; drug discovery; chemotherapy
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Emerging Technologies in Liquid Biopsy of Cancers
edited by Lingdi Yin
submission deadline 28 Feb 2026 | Viewed by 22 | Submission Open
Keywords: liquid biopsy; circulating tumor cells (CTCs); circulating tumor DNA (ctDNA); exosomes; cancer diagnostics; biomarker discovery; minimally invasive monitoring; emerging technologies; clinical translation; molecular profiling
(This special issue belongs to the Section Cancer Biology and Oncology)
Research Progress on Antimicrobial Resistance (AMR)
edited by
submission deadline 28 Feb 2026 | Viewed by 19 | Submission Open
Keywords: antimicrobial resistance; mechanism; therapy; experiment; bacteria; antibiotics
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
New Insights into the Diagnosis and Treatment of Hepatocellular Carcinoma—2nd Edition
edited by
submission deadline 28 Feb 2026 | Viewed by 18 | Submission Open
Keywords: checkpoint inhibitors; combinatorial treatments; hepatocellular carcinoma (HCC); immunotherapy; liver cancer; therapy; targeted therapy
(This special issue belongs to the Section Cancer Biology and Oncology)
Application of Artificial Intelligence in Biomedicines
edited by
submission deadline 28 Feb 2026 | Viewed by 18 | Submission Open
Keywords: artificial intelligence; generative artificial intelligence; precision medicine; clinical decision support; drug discovery; personalized therapy; trustworthy AI
(This special issue belongs to the Section Molecular and Translational Medicine)
Thyroid Disease: From Mechanism to Therapeutic Approaches (2nd Edition)
edited by
submission deadline 28 Feb 2026 | Viewed by 18 | Submission Open
Keywords: pathogenesis and molecular mechanism of thyroid diseases; genetic disorders of the thyroid; biomarkers for thyroid dysfunctions; diagnostic challenges; new thyroid’ s therapies; immunotherapy; nuclear medicine; minimally invasive treatment
(This special issue belongs to the Section Molecular and Translational Medicine)
New Advance in Wound Healing and Skin Regeneration
edited by and Siqi Fu
submission deadline 28 Feb 2026 | Viewed by 16 | Submission Open
Keywords: wound healing; skin regeneration; biomaterials; stem cell therapy; tissue engineering; bioactive dressings; 3D bioprinting; growth factors; chronic wounds; regenerative medicine
Regenerative Medicine for Bone and Cartilage
edited by Deryk Jones
submission deadline 28 Feb 2026 | Viewed by 15 | Submission Open
Keywords: articular cartilage; bone marrow lesion; osteochondral allograft and autograft; chondrocyte; trabeculae; magnetic resonance image; regeneration
(This special issue belongs to the Section Biomedical Engineering and Materials)
Pyroptosis and Cellular Stress: Emerging Mechanisms and Therapeutic Targets
edited by Gang Du
submission deadline 28 Feb 2026 | Viewed by 15 | Submission Open
Keywords: pyroptosis; cellular stress; ROS; programmed cell death; gasdermin; cytokines; inflammation; infection; cellular metabolism; immunometabolism
(This special issue belongs to the Section Cell Biology and Pathology)
Drug Resistance and Novel Targets for Cancer Therapy—Third Edition submission deadline 28 Feb 2026 | Viewed by 14 | Submission Open
Keywords: cancer; drug resistance; targeted therapy; conventional chemotherapy; natural products; molecular targets; cancer hallmarks; therapeutic agents
(This special issue belongs to the Section Cancer Biology and Oncology)
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