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Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Neurodegenerative Diseases: From Mechanisms to Therapeutic Approaches, 2nd Edition

edited by

Marie-Lise Maddelein

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1480 | Submission Open

Keywords: neurodegenerative diseases; neurons; mechanism

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Growth Hormone Disorders and Their Related Diseases: From Pathophysiology to Therapeutic Approaches

edited by

Giorgio Sodero

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1416 | Submission Open

Keywords: growth; growth hormone deficiency; GH; IGF-1; pediatric endocrinology

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Congenital Heart Disease: Diagnosis, Treatment and Prognosis

edited by

Gaetano Thiene

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1369 | Submission Open

Keywords: adult congenital heart disease; eisenmenger's syndrome; endocarditis; thromboprophylaxis

(This special issue belongs to the Section Molecular and Translational Medicine)

New Insights into the Diagnosis and Treatment of Hepatocellular Carcinoma—2nd Edition

edited by

Evangelos Koustas

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1319 | Submission Open

Keywords: checkpoint inhibitors; combinatorial treatments; hepatocellular carcinoma (HCC); immunotherapy; liver cancer; therapy; targeted therapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Advances in Precision Cancer Therapy

edited by

Yongheng Chen

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1110 | Submission Open

Keywords: personalized cancer therapy; targeted therapy; immunotherapy; cancer genomics; cancer biomarker; liquid biopsy; CAR-T cell therapy; kinase inhibitor; combination therapy; molecular profiling

(This special issue belongs to the Section Cancer Biology and Oncology)

Progress in Cytotoxicity of Biomaterials

edited by Lakkamraju Vijayalakshmi

submission deadline 28 Feb 2026 | 1 articles | Viewed by 983 | Submission Open

Keywords: biomaterial cytotoxicity; biocompatibility assessment; in vitro and in vivo toxicity; surface modification; nanomaterials in medicine; oxidative stress and inflammation; tissue engineering materials; drug delivery systems; biodegradable polymers; regulatory perspectives on biomaterial safety

(This special issue belongs to the Section Biomedical Engineering and Materials)

Multisystem Crosstalk in Health and Disease

edited by

Mehmet Bostancıklıoğlu

submission deadline 28 Feb 2026 | Viewed by 579 | Submission Open

Keywords: systems biology; immunometabolism; inflammation; integrative physiology; molecular pathways; translational research; multi-omics; chronic disease; host– microbe interactions; metabolic regulation

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Gastric Cancer: Molecular and Translational Aspects on Carcinogenesis and Treatment

edited by Sharona B. Ross

submission deadline 28 Feb 2026 | 1 articles | Viewed by 512 | Submission Open

Keywords: gastric cancer; tumor microenvironment; molecular mechanism; targeted therapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Peptide Therapeutic Approaches for Cancer Treatment

edited by

Prakash Lingasamy

and

Vijayachitra Modhukur

submission deadline 28 Feb 2026 | Viewed by 499 | Submission Open

Keywords: peptide therapeutics; cancer treatment; drug delivery systems; molecular imaging; bioinformatics; machine learning and artificial intelligence (AI); therapeutic targeting; peptide– drug conjugates; personalized medicine; immunotherapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Recent Advances in Adipokines (3nd Edition)

edited by

Christa Büchler

submission deadline 28 Feb 2026 | Viewed by 439 | Submission Open

Keywords: adiponectin; receptor; agonist; biomarker; inflammation; cancer

(This special issue belongs to the Section Cell Biology and Pathology)

Recent Advances in Primary and Relapsed Ovarian Cancer

edited by Cornelia Bachmann

submission deadline 28 Feb 2026 | Viewed by 360 | Submission Open

Keywords: ovarian cancer; relapse; BRCA; genetics; immunotherapy; biomarkers

(This special issue belongs to the Section Cancer Biology and Oncology)

Demyelinating Diseases: Pathophysiology and Emerging Therapeutic Targets

edited by Jude Taylor

submission deadline 28 Feb 2026 | Viewed by 355 | Submission Open

Keywords: demyelinating diseases; pathophysiological processes; diagnostic accuracy and predicting disease; emerging strategies

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

The Role of Environmental Pollutants in Cancer and Chemoresistance

edited by

Fabio Altieri

and

Margherita Eufemi

submission deadline 28 Feb 2026 | Viewed by 348 | Submission Open

Keywords: environmental pollutants; cancer cells; therapeutic agents

(This special issue belongs to the Section Cancer Biology and Oncology)

Advances of Amyloid-β Dynamics in Health and Diseases

edited by

Rahat Ullah

submission deadline 28 Feb 2026 | Viewed by 341 | Submission Open

Keywords: Alzheimer’ s disease (AD); amyloid-β clearance; brain and periphery; cerebral amyloid angiopathy (CAA)

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Innovations in Nanomedicine for Disease Management

edited by Anna Valentino and

Raffaele Conte

submission deadline 28 Feb 2026 | Viewed by 319 | Submission Open

Keywords: nanomedicine; nanoparticles; smart drug delivery; personalized medicine; minimally invasive treatments; gene therapy; regenerative medicine

(This special issue belongs to the Section Nanomedicine and Nanobiology)

Pathophysiology and Therapeutic Innovations in Skin and Appendage Disorders

edited by

Xuming Zhu

submission deadline 28 Feb 2026 | Viewed by 256 | Submission Open

Keywords: skin disorders; skin development; skin pathophysiology; tumorigenesis; psoriasis; atopic dermatitis; acne; innovative therapies; molecular dermatology; translational skin research

(This special issue belongs to the Section Cell Biology and Pathology)

Recent Advances in Biomedical Engineering for the Elderly

edited by

Siti Anom Ahmad

submission deadline 28 Feb 2026 | Viewed by 196 | Submission Open

Keywords: biomedical engineering; gerontechnology; artificial intelligence in healthcare; digital health; physiological signal processing; human– machine interaction; rehabilitation engineering

(This special issue belongs to the Section Biomedical Engineering and Materials)

Advances in Cancer Treatment

edited by

Vlasios Karageorgos

and

George Liapakis

submission deadline 28 Feb 2026 | Viewed by 176 | Submission Open

Keywords: targeted therapy; bio-conjugates; biologic agents; precision oncology; personalized cancer treatment; biomarker-guided therapy; cancer drug development; biopharmaceuticals

(This special issue belongs to the Section Cancer Biology and Oncology)

Cannabinoids in Therapeutics: Mechanisms, Signaling Pathways and Personalized Treatment Strategies

edited by

Jan Rožanc

and

Uroš Maver

submission deadline 28 Feb 2026 | Viewed by 172 | Submission Open

Keywords: cannabinoids; endocannabinoid system; cancer; pain; inflammation; personalized medicine; receptor signaling; therapeutic development; drug delivery; pharmacogenomics; systems pharmacology

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

New Advances in Wound Healing and Skin Regeneration

edited by

Bingrong Zhou

and Siqi Fu

submission deadline 28 Feb 2026 | Viewed by 163 | Submission Open

Keywords: wound healing; skin regeneration; biomaterials; stem cell therapy; tissue engineering; bioactive dressings; 3D bioprinting; growth factors; chronic wounds; regenerative medicine

Advances in Single-Cell and Spatial Transcriptomics: Decoding Tumor Heterogeneity and Microenvironment

edited by

Guanhu Yang

submission deadline 28 Feb 2026 | Viewed by 161 | Submission Open

Keywords: single-cell sequencing; spatial transcriptomics; tumor microenvironment; heterogeneity; immunotherapy resistance

(This special issue belongs to the Section Cancer Biology and Oncology)

Diagnostic and Therapeutic Approaches to Pancreatic Cancer—Second Edition

edited by

Sanchita Rauth

submission deadline 28 Feb 2026 | Viewed by 149 | Submission Open

Keywords: pancreatic cancer; systemic therapy; immunotherapy; tumor microenvironment; biomarkers

(This special issue belongs to the Section Cancer Biology and Oncology)

Glioblastoma: From Pathology to Novel Therapeutic Approaches

edited by Carlen A. Yuen

submission deadline 28 Feb 2026 | Viewed by 142 | Submission Open

Keywords: glioblastoma; EGFR; TERT; +7/-10; CAR T-cell therapy; immunotherapy; GammaTile® ; LITT

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Current Challenges and Future Trends in Intracranial Aneurysms: Mechanisms, Biomarkers, and Therapeutic Strategies

edited by Zhongsong Shi and

Aichi Chien

submission deadline 28 Feb 2026 | Viewed by 142 | Submission Open

Keywords: intracranial aneurysm; subarachnoid hemorrhage; inflammation; immune; smooth muscle cell; endothelial dysfunction; hemodynamic forces; biomarkers; neuroimaging; non-coding RNA; multi-omics; endovascular treatment; computational fluid dynamic

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Nervous System Injury and Repair: From Molecular Mechanism to Therapeutic Perspectives

edited by

Shuchao Wang

submission deadline 28 Feb 2026 | Viewed by 127 | Submission Open

Keywords: nervous system injury; neuron; astrocytes; microglial cells; excitotoxicity; inflammation; oxidative stress; neuroprotection

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Multidisciplinary Approaches to Neurodegenerative Disorders

edited by

Toomas Toomsoo

submission deadline 28 Feb 2026 | Viewed by 122 | Submission Open

Keywords: neurodegenerative disorders; lipid metabolism; comorbidity patterns super-agers; precision medicine; biomarker discovery; AI-assisted diagnostics; translational neuroscience; multi-omics integration; neuroinflammation

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Innovative Strategies for the Diagnosis and Treatment of Sarcopenia and Osteoporosis

edited by Wei-Bin Hsu and

Meng-Huang Wu

submission deadline 28 Feb 2026 | Viewed by 118 | Submission Open

Keywords: sarcopenia; osteoporosis; healthy aging; bone strength; muscle health; fracture prevention; pharmacological therapies; nutritional support; exercise rehabilitation

(This special issue belongs to the Section Molecular and Translational Medicine)

Fertility and Reproductive Health: Understanding of Reproductive Physiology and Pathology

edited by Sevastiani Antonouli and

Valentina Di Nisio

submission deadline 28 Feb 2026 | Viewed by 114 | Submission Open

Keywords: female infertility; male infertility; oocyte quality; embryo implantation; follicular dynamics; gamete and embryo ultrastructure; assisted reproduction technologies; reproductive aging; fertility preservation; oncofertility challenges

(This special issue belongs to the Section Gene and Cell Therapy)

New Advances in Pulmonary Fibrosis

edited by

Mari Ozaki

submission deadline 28 Feb 2026 | Viewed by 114 | Submission Open

Keywords: pulmonary fibrosis; interstitial lung disease; antifibrotic therapy; precision medicine; imaging diagnostics; novel therapeutics; pathobiology; artificial intelligence

(This special issue belongs to the Section Molecular and Translational Medicine)

Novel Insight into Human Reproductive Medicines

edited by

Bo Huang

submission deadline 28 Feb 2026 | Viewed by 111 | Submission Open

Keywords: IVF; oocyte; sperm; clinical outcome; embryo; ovulation induction; fertilization; PGT

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Drug Resistance and Novel Targets for Cancer Therapy—Third Edition

edited by

Bruno Kaufmann Robbs

and

Fernando de Carvalho da Silva

submission deadline 28 Feb 2026 | Viewed by 106 | Submission Open

Keywords: cancer; drug resistance; targeted therapy; conventional chemotherapy; natural products; molecular targets; cancer hallmarks; therapeutic agents

(This special issue belongs to the Section Cancer Biology and Oncology)

Immune and Metabolic Dysregulation in Neurological and Neuropsychiatric Disorders

edited by

Qingkun Liu

and

Xin-An Liu

submission deadline 28 Feb 2026 | Viewed by 105 | Submission Open

Keywords: neuroimmune interaction; neuroinflammation; metabolic regulation; gut– brain axis; microbiome; neuroendocrine system; neurodegeneration; psychiatric disorders; brain injuries

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Neurotrauma: Mechanisms, Pathways, and Emerging Therapeutic Interventions, 2nd Edition

edited by Kevin Pierre and

Brandon Lucke-Wold

submission deadline 28 Feb 2026 | Viewed by 102 | Submission Open

Keywords: neurotrauma; traumatic brain injury; spinal cord injury; inflammation; oxidative stress; excitotoxicity; diagnostic biomarkers; imaging techniques; neuroprotection; neurogeneration

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Immune Cell Reprogramming: Molecular Mechanisms and Therapeutic Approaches

edited by

Santarsiero Anna

Vittoria Infantino

and Paolo Convertini

submission deadline 28 Feb 2026 | Viewed by 98 | Submission Open

Keywords: immune cell reprogramming; immunometabolism; macrophage activation; gene expression regulation; cell signaling; innate immunity; adaptive immunity; metabolic disorders; chronic inflammation; targeted therapies

(This special issue belongs to the Section Immunology and Immunotherapy)

Recent Advances in Diagnosis and Therapeutic Strategies in Intraocular Inflammation—Second Edition

edited by

Uwe Pleyer

submission deadline 28 Feb 2026 | Viewed by 96 | Submission Open

Keywords: biomarker; diagnosis; immune pharmacology; immune regulation; immune system; infection; uveitis; therapy

(This special issue belongs to the Section Immunology and Immunotherapy)

Human Stem Cells in Disease Modelling and Treatment (2nd Edition)

edited by Sofia M. Calado and

Álvaro Plaza Reyes

submission deadline 28 Feb 2026 | Viewed by 89 | Submission Open

Keywords: induced pluripotent stem cells (iPSCs); embryonic stem cells (ESCs); disease models; cell therapies; cell therapy medicinal products (CTMPs); regenerative medicine

(This special issue belongs to the Section Biomedical Engineering and Materials)

Neuroimmunology and Neurological Infection

edited by

Mariya Ivanovska

submission deadline 28 Feb 2026 | Viewed by 89 | Submission Open

Keywords: neuroimmunology; neurological infections; immune-mediated diseases; neurodegeneration; biomarkers; immunotherapy; neuroinflammation; clinical neurology

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

New Insights into Breast Cancer Management: From Tumorigenesis to Personalized Treatments—2nd Edition

edited by

Rita De Sanctis

and

Paola Tiberio

submission deadline 28 Feb 2026 | Viewed by 88 | Submission Open

Keywords: breast cancer; diagnosis; prognosis; treatment response prediction; biomarkers; risk factors; new therapies

(This special issue belongs to the Section Cancer Biology and Oncology)

Eicosanoids and Fatty Acids in Health, Diseases and Therapeutics

edited by Mihai Nechifor

submission deadline 28 Feb 2026 | Viewed by 86 | Submission Open

Keywords: eicosanoids; prostaglandins; leukotrienes; prostacyclin; lipoxins; resolvins; protectins; maresins; arachidonic acid (AA); eicosapentaenoic acid (EPA); docosahexaenoic acid (DHA); cell functions; immunity; cardiovascular; neuropsychiatric; metabolic; digestive; reproductive; hematologic; inflammatory and oncologic pathology; therapeutics

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Decoding Resistance: Molecular Drivers of Therapy Failure in Advanced Prostate Cancer

edited by

Jyoti Kaushal

submission deadline 28 Feb 2026 | Viewed by 85 | Submission Open

Keywords: prostate cancer; androgen deprivation therapy; molecular signaling; epigenetic remodeling; cancer stem cell; tumor microenvironment

(This special issue belongs to the Section Cancer Biology and Oncology)

Anticancer Drugs in Immunotherapy: Molecular Mechanisms, Translational Insights, and Clinical Applications

edited by

Bashir Lawal

submission deadline 28 Feb 2026 | Viewed by 84 | Submission Open

Keywords: immunotherapy; immune checkpoint inhibitors; drug synergy; immunogenic cell death; tumor microenvironment; cancer immunology; combination therapy; chemotherapy; targeted therapy; translational oncology

(This special issue belongs to the Section Cancer Biology and Oncology)

Emerging Technologies in Liquid Biopsy of Cancers

edited by Lingdi Yin

submission deadline 28 Feb 2026 | Viewed by 83 | Submission Open

Keywords: liquid biopsy; circulating tumor cells (CTCs); circulating tumor DNA (ctDNA); exosomes; cancer diagnostics; biomarker discovery; minimally invasive monitoring; emerging technologies; clinical translation; molecular profiling

(This special issue belongs to the Section Cancer Biology and Oncology)

Research Progress on Antimicrobial Resistance (AMR)

edited by

Tomohiro Oishi

submission deadline 28 Feb 2026 | Viewed by 83 | Submission Open

Keywords: antimicrobial resistance; mechanism; therapy; experiment; bacteria; antibiotics

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Kidney Disease: From Pathophysiology to Treatment

edited by

Paola Pontrelli

and

Francesca Conserva

submission deadline 28 Feb 2026 | Viewed by 81 | Submission Open

Keywords: acute kidney injury; chronic kidney disease; precision medicine; molecular mechanisms; biomarkers; therapeutic response

Liver Cancer: Molecular and Translational Insights of Carcinogenesis and Treatments

edited by

Joon Hyuk Choi

submission deadline 28 Feb 2026 | Viewed by 80 | Submission Open

Keywords: liver cancer; hepatocellular carcinoma; intrahepatic cholangiocarcinoma; carcinogenesis; premalignant lesions; diagnosis; pathology; treatment

(This special issue belongs to the Section Cancer Biology and Oncology)

Emerging Trends in Dental Caries: Insights into Etiology, Risk Factors, and Treatment Strategies (2nd Edition)

edited by

Hee-Eun Kim

submission deadline 28 Feb 2026 | Viewed by 77 | Submission Open

Keywords: antimicrobial effect; demineralization; dental caries; dental plaque; oral biofilm; oral disease; oral management; pathogenicity; prevention; remineralization

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Thyroid Disease: From Mechanism to Therapeutic Approaches (2nd Edition)

edited by

Beata Wojtczak

submission deadline 28 Feb 2026 | Viewed by 76 | Submission Open

Keywords: pathogenesis and molecular mechanism of thyroid diseases; genetic disorders of the thyroid; biomarkers for thyroid dysfunctions; diagnostic challenges; new thyroid’ s therapies; immunotherapy; nuclear medicine; minimally invasive treatment

(This special issue belongs to the Section Molecular and Translational Medicine)

Pyroptosis and Cellular Stress: Emerging Mechanisms and Therapeutic Targets

edited by Gang Du

submission deadline 28 Feb 2026 | Viewed by 75 | Submission Open

Keywords: pyroptosis; cellular stress; ROS; programmed cell death; gasdermin; cytokines; inflammation; infection; cellular metabolism; immunometabolism

(This special issue belongs to the Section Cell Biology and Pathology)

Advances in Liver Fibrosis: From Mechanisms to Therapeutics

edited by

Kun Zhang

submission deadline 28 Feb 2026 | Viewed by 75 | Submission Open

Keywords: liver fibrosis; therapeutic target; biomarker; hepatocyte; macrophage; LSEC; HSC; immune cells; extracellular matrix

(This special issue belongs to the Section Molecular and Translational Medicine)

Molecular Diagnostics in Diabetes: From Biomarkers to Clinical Applications

edited by