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Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Feature Reviews on Diabetes Pathophysiology and Treatment

edited by

Chrysi Koliaki

submission deadline 31 Dec 2025 | Viewed by 487 | Submission Open

Keywords: type 1 diabetes mellitus; type 2 diabetes mellitus; pathophysiology; treatment; self-management; technology; continuous glucose monitoring; pump therapy; digital applications

(This special issue belongs to the Section Molecular and Translational Medicine)

Liver Fibrosis: Molecular Mechanisms, Potential Therapeutic Targets and Clinical Biomarkers, 2nd Edition

edited by

Takefumi Kimura

submission deadline 31 Dec 2025 | Viewed by 431 | Submission Open

Keywords: liver fibrosis treatment; therapeutic target biomarker; hepatitis; NAFLD; NASH; MAFLD; HSC; GPCR; immunity cell death

(This special issue belongs to the Section Molecular and Translational Medicine)

CDK Inhibitors: A New Wave of Therapeutic Agents for Human Diseases

edited by Mengqian Chen

submission deadline 31 Dec 2025 | Viewed by 419 | Submission Open

Keywords: cyclin-dependent kinases (CDKs); cell-cycle CDKs; transcriptional CDKs; CDK inhibitors; CDK degraders; cancer therapeutics; inflammatory diseases; neurodegenerative disorders; pharmacology; clinical trials

(This special issue belongs to the Section Cancer Biology and Oncology)

New Challenges in the Study of Liver Diseases: From Molecular Pathogenesis to Therapeutic Approaches—4th Edition

edited by

Marica Meroni

submission deadline 31 Dec 2025 | 1 articles | Viewed by 394 | Submission Open

Keywords: liver diseases and related pathologies; non-alcoholic fatty liver diseases (NAFLDs); obesity; type 2 diabetes; cardiovascular diseases; gut– liver axis; viral hepatitis; alcoholic liver diseases (ALDs); cholestatic disorders; personalized medicine

(This special issue belongs to the Section Molecular and Translational Medicine)

Neglected Infectious Diseases: From Pathophysiology to Therapy

edited by Raimunda Nonata Ribeiro Sampaio

submission deadline 31 Dec 2025 | Viewed by 378 | Submission Open

Keywords: pathophysiology; host– parasite infection interactions; diagnostic tools; therapeutic intervention; novel biomarkers

(This special issue belongs to the Section Microbiology in Human Health and Disease)

State-of-the-Art Neurobiology and Clinical Neuroscience in the United States

edited by

Justin Miller

and

Laura Ibanez

submission deadline 31 Dec 2025 | Viewed by 346 | Submission Open

Keywords: neurobiology; neuroscience; bioinformatics; Alzheimer’ s disease; Parkinson’ s disease; imaging; neurotransmitters; neurodegeneration; clinical; population genetics

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Nanomedicine Applications in the Diagnosis and Treatment of Neurodegenerative Diseases

edited by

Sudipta Senapati

submission deadline 31 Dec 2025 | Viewed by 331 | Submission Open

Keywords: neurodegenerative diseases; nanomedicine; blood– brain barrier permeability; early diagnosis and treatment; biosensing and bioimaging

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

State-of-the-Art Molecular and Translational Medicine in USA

edited by

Maaike van Gerwen

and

Stephanie J. Tuminello

submission deadline 31 Dec 2025 | Viewed by 305 | Submission Open

Keywords: diagnostics; therapeutics; prevention; cellular biology; disease mechanisms; precision medicine; biomarker discovery; immunotherapies; bioinformatics

(This special issue belongs to the Section Molecular and Translational Medicine)

Neuromuscular Diseases: From Pathophysiology to Novel Therapeutic Approaches

edited by Marco A.F. Fernandes

submission deadline 31 Dec 2025 | Viewed by 293 | Submission Open

Keywords: neuromuscular diseases; amyotrophic lateral sclerosis (ALS); muscular dystrophy; myasthenia gravis; neuromyotonia; peripheral neuropathy; pathophysiology; gene therapy; targeted drugs; regenerative medicine

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Recent Advances in Gastrointestinal Cancers: From Microbiota Modulation to New Therapeutic Approaches—2nd Edition

edited by

Serena Martinelli

submission deadline 31 Dec 2025 | 1 articles | Viewed by 241 | Submission Open

Keywords: gastrointestinal cancers; microbiota; anticancer therapy; immunotherapy; precision medicine

(This special issue belongs to the Section Cancer Biology and Oncology)

Diagnosis, Pathogenesis and Treatment of CNS Tumors (2nd Edition)

edited by

Dimitrios Kanakis

submission deadline 31 Dec 2025 | Viewed by 239 | Submission Open

Keywords: CNS tumors; diagnosis; pathogenesis; treatment; prognosis; molecular markers

(This special issue belongs to the Section Molecular and Translational Medicine)

Fetal Medicine: New Insights and Future Direction

edited by

Mateusz Zamłyński

submission deadline 31 Dec 2025 | Viewed by 231 | Submission Open

Keywords: fetal medicine; fetal therapy; prenatal screening; congenital defects; high-risk pregnancy

(This special issue belongs to the Section Molecular and Translational Medicine)

Unleashing the Power of Innovative Nanoparticles for Enhanced Radiation Therapy

edited by Fangchao Jiang

submission deadline 31 Dec 2025 | Viewed by 222 | Submission Open

Keywords: nanomedicine; drug delivery; radiation therapy; nanotheranostics; nanoparticles; cancer treatment; biomaterial

(This special issue belongs to the Section Nanomedicine and Nanobiology)

Supraventricular and Ventricular Cardiac Arrhythmias Systemic Implications: From Mechanisms to Clinical Treatment

edited by

Alina Negru

and

Gabriel Cismaru

submission deadline 31 Dec 2025 | Viewed by 216 | Submission Open

Keywords: cardiac arrhythmias; atrial fibrillation; ventricular tachycardia; AVNRT; PVC; supraventricular tachycardia; catheter ablation; electrophysiological study; heart failure; arrhythmias diagnostic; antiarrhythmic treatment; biomarkers; ion channels; cardiac resynchronization therapy; ICD

(This special issue belongs to the Section Molecular and Translational Medicine)

Zebrafish Models for Development and Disease—5th Edition

edited by

James A. Marrs

submission deadline 31 Dec 2025 | Viewed by 207 | Submission Open

Keywords: disease model; drug screening model; teratogen screening; toxicological screening; neuroscience; behavior; developmental biology

(This special issue belongs to the Section Molecular and Translational Medicine)

Molecular Regulation of Cancer Progression and Metastasis to Identify Novel Treatment Strategies

edited by

Vrushank Bhatt

submission deadline 31 Dec 2025 | Viewed by 182 | Submission Open

Keywords: cancer; cancer progression; cancer treatment; solid tumors; immune response; metastasis; tumor suppressor; oncogene

(This special issue belongs to the Section Cancer Biology and Oncology)

Feature Review: Advanced Manufacturing, Biomaterials, and Stem Cells for Tissue and Regenerative Engineering

edited by

Roozbeh Ross Salary

submission deadline 31 Dec 2025 | Viewed by 177 | Submission Open

Keywords: advanced manufacturing; biomaterials; tissue engineering; regenerative medicine

(This special issue belongs to the Section Biomedical Engineering and Materials)

NASH and Hepatocellular Carcinoma (HCC)—2nd Edition

edited by

Feng He

Ruirui Wang

and Xin Yang

submission deadline 31 Dec 2025 | Viewed by 155 | Submission Open

Keywords: NAFLD; NASH; HCC; obesity; inflammation; immunotherapy; stress

(This special issue belongs to the Section Cancer Biology and Oncology)

Advances in Wound Healing

edited by

Qi Zhang

and

Yiwei Qi

submission deadline 31 Dec 2025 | Viewed by 148 | Submission Open

Keywords: wound healing; scar and keloid; diabetic ulcers; multi-omics analysis for wound healing; biomaterials for wound healing; tissue engineering for wound healing; wound infection management; clinical trials and cases of wound healing

(This special issue belongs to the Section Molecular and Translational Medicine)

Feature Reviews in Imaging Technology for Human Diseases

edited by

Giulio Distefano

and

Antonio Granata

submission deadline 31 Dec 2025 | Viewed by 137 | Submission Open

Keywords: medical imaging; advanced radiological techniques; artificial intelligence; molecular imaging; computed tomography (CT); magnetic resonance imaging (MRI); ultrasound; fluoroscopy; optical imaging; liquid biopsy

(This special issue belongs to the Section Biomedical Engineering and Materials)

Advances in Hematological Malignancies: Diagnostic Strategies, Molecular Mechanisms, Prognostic Markers and Therapeutic Approaches

edited by José Antonio García-Vela and Fernando Martin-Moro

submission deadline 31 Dec 2025 | Viewed by 125 | Submission Open

Keywords: hematological malignancies; diagnostic strategies; hematopathology; flow cytometry; molecular biology; prognostic markers; targeted therapies; immunotherapy; cellular therapy

(This special issue belongs to the Section Molecular and Translational Medicine)

Nanobiomaterials with Antimicrobial and Anticancer Applications: Second Edition

edited by

Rajni Verma

and

Saurabh Pathak

submission deadline 31 Dec 2025 | Viewed by 122 | Submission Open

Keywords: nanobiomaterials; nanomaterials biomaterials; anti-bacterial; anti-cancer

(This special issue belongs to the Section Nanomedicine and Nanobiology)

Current Perspectives on Gynecologic Cancers

edited by

Kecheng Huang

submission deadline 31 Dec 2025 | Viewed by 117 | Submission Open

Keywords: gynecology; genetics; biology; bioinformatics; review; predictive model; artificial intelligence

(This special issue belongs to the Section Cancer Biology and Oncology)

Mitochondrial Function as a Target in Nanomedicine

edited by

Agnieszka Pyrczak-Felczykowska

submission deadline 31 Dec 2025 | Viewed by 98 | Submission Open

Keywords: nanomedicine; nanoparticles; drug delivery; mitochondria; cancer; neurodegenerative disease; metabolism; targeted therapy; mitochondrial function; bioactive compounds.

(This special issue belongs to the Section Nanomedicine and Nanobiology)

Omics Approaches on Immune-Mediated Inflammatory Diseases: Towards Novel Biomarkers and Potential Therapeutic Targets, 3rd Edition

edited by

Maria-Ioanna Christodoulou

submission deadline 31 Dec 2025 | Viewed by 96 | Submission Open

Keywords: IMIDs; IBD; Crohn’ s disease; ulcerative colitis; SLE; Sjogren’ s syndrome; rheumatoid arthritis; psoriatic arthritis; multiple sclerosis; bulk and single-cell omics; multi-omics flow cytometry; next-generation microscopy; tissue microarrays; systems biology

(This special issue belongs to the Section Immunology and Immunotherapy)

Breast Cancer Research: Charting Future Directions

edited by

Mohamad Adam Bujang

submission deadline 31 Dec 2025 | Viewed by 82 | Submission Open

Keywords: personalized medicine; biomarkers for early detection; immunotherapy; patient-reported outcomes

(This special issue belongs to the Section Cancer Biology and Oncology)

Exploring Neuroinflammation in Central and Peripheral Neuropathic Pain and Related Disorders

edited by

Tahmineh Mokhtari

submission deadline 31 Dec 2025 | Viewed by 81 | Submission Open

Keywords: neuroinflammation; neuropathic pain; central nervous system; peripheral nervous system; affective disorders; cognitive disorders; in silico modeling; in vitro assays; in vivo models; medical and non-pharmacological interventions

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Mechanism of Mesenchymal Stromal Cells and Their Derivatives in Regenerative Medicine

edited by Jia Xian Law and

Kok Lun Pang

submission deadline 31 Dec 2025 | Viewed by 77 | Submission Open

Keywords: mesenchymal stromal cell; regenerative medicine; stem cell; extracellular vesicle; mechanism of action; paracrine factor; secretome; tissue engineering

(This special issue belongs to the Section Biomedical Engineering and Materials)

Three-Dimensional Printed Meshes in Guided Bone Regeneration

edited by

Giulia Guarnieri

Annamaria Morelli

and

Claudio Cirrincione

submission deadline 31 Dec 2025 | Viewed by 74 | Submission Open

Keywords: 3D– 4D printing; vascular metabolism; mucosal stiffness; bone and gingival cells metabolism; bioprinting; melt electrowriting; shape-memory materials; titanium and polycaprolactone meshes

(This special issue belongs to the Section Biomedical Engineering and Materials)

Advancements and Innovations in Chemotherapy

edited by

Yu-Jung Lin

submission deadline 31 Dec 2025 | Viewed by 74 | Submission Open

Keywords: chemotherapy; drug resistance; immunotherapy; combination therapy; drug delivery systems; novel agents; personalized medicine; tumor microenvironment

(This special issue belongs to the Section Cell Biology and Pathology)

New Insights in Reproductive Health and Disease

edited by

Chi Chiu Wang

submission deadline 31 Dec 2025 | Viewed by 71 | Submission Open

Keywords: reproductive health; artificial intelligence; fertility preservation; stem cells; gene therapy; materials; meiosis; DNA double-strand break; ovarian dysfunction; nanomedicine; pregnancy complications

(This special issue belongs to the Section Molecular and Translational Medicine)

HIV Therapy: The Latest Developments in Antiviral Drugs

edited by

Francisco Javier Fanjul Losa

submission deadline 31 Dec 2025 | Viewed by 69 | Submission Open

Keywords: HIV; antiviral drugs; experimental therapeutics; drug discovery; viral reservoirs; mechanism of action; preclinical models; novel HIV targets; antiretroviral therapy (ART); immunotherapy (experimental aspects)

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Advances in Heart–Brain Axis

edited by Teresa Soda

submission deadline 31 Dec 2025 | Viewed by 67 | Submission Open

Keywords: heart– brain axis; neurocardiology; autonomic nervous system; neuroinflammation; cardiac– cerebral syndromes; psychocardiology; calcium signaling; synaptic plasticity; ion transport; translational neuroscience

(This special issue belongs to the Section Molecular and Translational Medicine)

The Role of Telomere and Telomerase in Human Disease-2nd Edition

edited by

Orit Uziel

submission deadline 31 Dec 2025 | Viewed by 66 | Submission Open

Keywords: telomere; telomerase; cancer; aging

(This special issue belongs to the Section Molecular and Translational Medicine)

Advanced Research on Diabetic Retinopathy

edited by Stamatios Lampsas

submission deadline 31 Dec 2025 | Viewed by 62 | Submission Open

Keywords: diebetic retinopathy; retinal diseases; novel treatment strategies; progression; pathogenetic mechanisms; non-proliferative diabetic retinopathy; proliferative diabetic retinopathy

(This special issue belongs to the Section Molecular and Translational Medicine)

Pharmacogenomics and Drug Metabolism: From Cytochrome P450 to Emerging Enzymatic Pathways

edited by

Pradeepraj Durairaj

submission deadline 31 Dec 2025 | Viewed by 59 | Submission Open

Keywords: cytochrome P450 (CYP450); drug metabolism; xenobiotic metabolism; pharmacogenomics; biotransformation; orphan enzymes; redox biology; enzyme engineering; multi-omics approaches; personalized medicine

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Gene- and Peptide-Based Therapeutics for Neurodegenerative Disorders

edited by

Ramona Meanti

and Chiara Lucchi

submission deadline 31 Dec 2025 | Viewed by 57 | Submission Open

Keywords: neurodegenerative diseases; gene therapy; peptide-based therapeutics; targeted drug delivery; neuroprotection

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Dopamine and Androgen Receptor Signaling: Novel Insights in Cancer Biology

edited by Srijan Acharya

submission deadline 31 Dec 2025 | Viewed by 50 | Submission Open

Keywords: dopamine signaling; androgen receptor; cancer biology; hormone-sensitive tumors; signal transduction; tumor microenvironment; neurotransmitters in cancer; prostate cancer; breast cancer; targeted therapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Oxidative Stress in Health and Disease

edited by Federica Mannino

submission deadline 31 Dec 2025 | Viewed by 49 | Submission Open

Keywords: oxidative stress; inflammation; human diseases; apoptosis; peroxidation; DNA damage; mitochondria

(This special issue belongs to the Section Cell Biology and Pathology)

Molecular Biology of Cancer: From Biomarkers to Targeted Therapy

edited by

Georgia Levidou

submission deadline 31 Dec 2025 | Viewed by 47 | Submission Open

Keywords: molecular biology; carcinogenesis; cancer; biomarkers; prognostic markers; predictive markers; precision medicine; targeted therapy

(This special issue belongs to the Section Cell Biology and Pathology)

Advances in Precision Oncology for Thyroid Carcinoma: Integrating Artificial Intelligence, Genomics and Molecular Diagnostics

edited by

Kyoung Sik Park

submission deadline 31 Dec 2025 | Viewed by 44 | Submission Open

Keywords: thyroid carcinoma; artificial intelligence; genomics; precision oncology; molecular diagnostics

(This special issue belongs to the Section Cancer Biology and Oncology)

Pathogenesis and Novel Diagnostic Techniques in Juvenile Idiopathic Arthritis—Second Edition

edited by

Katarzyna Winsz-Szczotka

submission deadline 31 Dec 2025 | Viewed by 44 | Submission Open

Keywords: juvenile idiopathic arthritis; pathogenesis; cartilage and bone anabolism and catabolism; diagnostics; treatment; prevention

(This special issue belongs to the Section Molecular and Translational Medicine)

MicroRNAs in Precision Medicine: Regulation, Biomarkers and Novel Therapeutics

edited by Shing Cheng Tan

submission deadline 31 Dec 2025 | Viewed by 44 | Submission Open

Keywords: MicroRNAs; non-coding RNAs; biomarkers; therapeutic targets; cancer; omics technologies; precision medicine; disease pathogenesis

(This special issue belongs to the Section Molecular and Translational Medicine)

Oral Squamous Cell Carcinoma: Molecular Signaling Pathways and Novel Biomarkers—2nd Edition

edited by

Sadhna Aggarwal

submission deadline 31 Dec 2025 | Viewed by 41 | Submission Open

Keywords: oral squamous cell carcinoma (OSCC); molecular signaling pathways; biomarkers; pathogenesis; targeted therap; tumor growth; tumor invasion; angiogenesis; tumor metastasis; immune response modulation

(This special issue belongs to the Section Cancer Biology and Oncology)

Glomerular Disease and Cystic Kidney Disease: From Pathogenesis to Novel Therapeutic Approaches—2nd Edition

edited by Vassilis Filiopoulos and

Chrysanthi Skalioti

submission deadline 31 Dec 2025 | Viewed by 41 | Submission Open

Keywords: glomerular disease; glomerulonephritis; glomerulopathy; podocytopathies; ciliopathies; cystic kidney disease; polycystic kidney disease; tolvaptan; vasopressin

(This special issue belongs to the Section Molecular and Translational Medicine)

Epigenetics in Human Cancer: Emerging Biomarkers and Therapeutic Targets

edited by

Jeong-yeon Lee

submission deadline 31 Dec 2025 | Viewed by 35 | Submission Open

Keywords: cancer; epigenetics; DNA methylation; histone modification; chromatin remodeling; non-coding RNAs; therapeutic resistance

(This special issue belongs to the Section Cancer Biology and Oncology)

Advances in Chondrocyte Biology (2nd Edition)

edited by

Bo Qiu

submission deadline 31 Dec 2025 | Viewed by 33 | Submission Open

Keywords: osteoarthritis; chondrocyte; differentiation; proliferation; signaling pathways; transcription factor; inflammation; cellular processes; cartilage repair

(This special issue belongs to the Section Cell Biology and Pathology)

Genetic Research on Colorectal Cancers

edited by

Wangxiong Hu

submission deadline 31 Dec 2025 | Viewed by 31 | Submission Open

Keywords: high microsatellite instability; epigenetic age acceleration; spatial omics and single-cell sequencing; cold tumors and immunotherapy; driver gene; DNA replication repair; liquid biopsy; ctDNA

(This special issue belongs to the Section Cancer Biology and Oncology)

Animal Models for the Study of Cardiovascular Physiology—Second Edition

edited by Sandra Lia Amaral

submission deadline 31 Dec 2025 | Viewed by 30 | Submission Open

Keywords: hypertension; stroke; myocardium infarction; arterial stiffness; supravalvular aortic stenosis; cardiac remodeling; capillary angiogenesis; exercise training; vascular diseases; non-pharmacological treatment

(This special issue belongs to the Section Cell Biology and Pathology)

Pathogenesis and Therapeutic Intervention of Alzheimer's Disease

edited by Chanchal Sharma

submission deadline 31 Dec 2025 | Viewed by 28 | Submission Open

Keywords: dementia; Alzheimer’ s disease; neuroinflammation; microglia; gene therapy; stem cells; blood– brain barrier; oxidative stress; gut-microbiome; diet; artificial intelligence

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

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