Musculoskeletal Diseases: From Molecular Basis to Therapy (Volume II)

Dear Colleagues,

Musculoskeletal diseases comprise numerous different disorders (more than 150 conditions) affecting the locomotor system (joints, bones, muscles, cartilage, meniscus and tendon tissues) and are associated with significant morbidity and disability. A recent analysis of the Global Burden of Disease estimated that approximately 1.71 billion people globally have musculoskeletal conditions. The number of affected individuals is expected to grow as the population ages. Thus, a better understanding of the etiology and new and more effective therapeutic treatments are needed. The purpose of this Special Issue is to report advances in pathophysiological mechanisms, predictive biomarkers and preclinical therapeutic approaches to musculoskeletal disorders, with a particular focus on bone cancers and osteoarthritis.

Authors are invited to contribute to this Special Issue with original research articles and comprehensive reviews.

Topics include, but are not limited to, the following:

• Pathophysiological studies related to musculoskeletal diseases;
• Molecular, biochemical and biomechanical mechanisms involved in the etiology and progression of musculoskeletal disorders;
• Identification of biomarkers useful for early diagnosis and/or predictive of prognosis;

Preclinical research of potential drugs and cell-based strategies for the treatment of musculoskeletal disorders.

Dr. Elisa Belluzzi
Dr. Assunta Pozzuoli
Guest Editors

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