Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.2
3.9
Journals
Biomedicines
Special Issues
Biotechnology in the Treatment and Management of Hearing Loss
share announcement

Biotechnology in the Treatment and Management of Hearing Loss

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Biomedical Engineering and Materials".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 1594

Special Issue Editor

Dr. Alessandro Castiglione

E-Mail Website
Guest Editor
Department of Audiology, Orebro University Hospital, Interdisciplinary Research in Clinical Audiology—IRCA, Orebro University, 70116 Orebro, Sweden
Interests: gene therapy; genetics; stem cells; hearing loss; nanotechnologies

Special Issue Information

Dear Colleagues,

The Special Issue aims to explore the latest advancements in and applications of biotechnological innovations in diagnosing, treating and managing hearing impairments. Hearing loss affects millions globally, significantly impacting the quality of life and communication abilities. This Special Issue seeks to provide a comprehensive overview of cutting-edge biotechnological approaches, including gene therapy, regenerative medicine, advanced auditory implants and nanotechnology, that are revolutionizing the field.

Recent research trends highlight the potential of gene editing tools such as CRISPR-Cas9 for correcting genetic mutations responsible for hereditary hearing loss, as well as the use of stem cells for regenerating damaged auditory cells. Additionally, the development of more sophisticated and miniaturized cochlear implants and hearing aids, enhanced with artificial intelligence, is improving patient outcomes. This Special Issue invites original research articles and reviews that discuss these innovations, their clinical applications and future prospects.

By bringing together diverse research and perspectives, this Special Issue aims to foster collaboration among scientists, clinicians and industry professionals, ultimately advancing the understanding and treatment of hearing loss through biotechnological means.

Dr. Alexander Castiglione
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hearing loss
  • gene therapy
  • regenerative medicine
  • cochlear implants
  • nanotechnology stem cell therapy
  • CRISPR-Cas9
  • auditory prosthetics
  • artificial intelligence
  • auditory regeneration

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

14 pages, 2335 KiB  
Article
Transimpedance Matrix Measurement (TIM) Parameters Evaluation for the Assessment of Cochlear Implant Electrode Placement and Modiolar Proximity in Children
by Katarzyna Radomska, Marcin Talar, Karolina Haber, Paulina Mierzwińska-Dolny, Andrew J. Fishman and Józef Mierzwiński
Biomedicines 2025, 13(2), 319; https://doi.org/10.3390/biomedicines13020319 - 29 Jan 2025
Viewed by 897
Abstract
Introduction: Transimpedance matrix measurement (TIM) is an electrophysiological measurement protocol of the impedance patterns of electrode contacts within the cochlea. Several studies have reported that TIM is an effective tool for the identification of abnormal electrode array placement. However, the normative values [...] Read more.
Introduction: Transimpedance matrix measurement (TIM) is an electrophysiological measurement protocol of the impedance patterns of electrode contacts within the cochlea. Several studies have reported that TIM is an effective tool for the identification of abnormal electrode array placement. However, the normative values for properly inserted electrodes, as well as correlation of the TIM patterns with the electrode position, are not completely determined. Objectives: The first aim of this study is to establish normative values of TIM measurements obtained in children with proper electrode array insertion and tip fold-over, with proper inner ear anatomy and in congenital anomalies. The second aim of this study is to compare TIM measurements in Slim Modiolar (SM) and in Contour Advance (CA) electrodes, as their position is different according to the modiolus proximity. Methods: A total of 55 pediatric patients were included in the study and underwent cochlear implantation. 62 intraoperative measurements were conducted in this group—50 in children with normal inner ear anatomy and 12 in children with inner ear malformations. After each implantation, a plain x-ray was obtained. Results: There were clear statistically significant differences in TIM patterns in patients where electrode fold-over was confirmed and between SM and CA electrodes. Conclusions: TIM is a promising technique for intraoperative analysis of electrode placement. TIM patterns differ and correlate consistently with the different models of array implanted. This study is the first to report TIM patterns observed in children with normal inner ear anatomy and in inner ear malformations. Full article
(This article belongs to the Special Issue Biotechnology in the Treatment and Management of Hearing Loss)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop