Meningioma: Novel Diagnostic and Therapeutic Approaches

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 1296

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Neuro-Oncology Division, Department of Neurology, University of California, Irvine, CA 92868, USA
Interests: neurology; neuro-oncology
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Special Issue Information

Dear Colleagues,

This Special Issue, titled “Meningioma: Novel Diagnostic and Therapeutic Approaches”, will collate innovative research and comprehensive reviews focused on novel diagnostic and treatment modalities for meningiomas. In light of the accumulating evidence for molecular markers in the grading of meningiomas, PET DOTATATE for the detection of meningiomas, and targeted therapies for the treatment of meningiomas, this Special Issue will explore the advancements made in these areas.

We invite submissions that highlight novel imaging modalities, molecular alterations, and targeted therapies for meningiomas. Topics may include (but are not limited to) the application of PET DOTATATE for the identification of viable tumor and in radiation planning, molecular alterations that predict recurrence risk, and innovative therapies, including Lutetium-177 and targeted therapies. Contributions addressing challenges in identifying novel molecular markers to stratify risk are more than welcome. This Special Issue aims to provide a broad detailed overview of the recent advancements made and future directions in the diagnosis and treatment of meningiomas. This Special Issue will provide a guide for neuro-oncologists to support improved patient outcomes and deliver personalized medicine to their patients.

Dr. Carlen A Yuen
Guest Editor

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Keywords

  • meningioma
  • atypical
  • anaplastic
  • PET DOTATATE
  • octreotide
  • Lutetium-177
  • targeted therapy

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Published Papers (1 paper)

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Review

19 pages, 769 KiB  
Review
Meningioma: Novel Diagnostic and Therapeutic Approaches
by Carlen A. Yuen, Michelle Zheng, Max A. Saint-Germain and David O. Kamson
Biomedicines 2025, 13(3), 659; https://doi.org/10.3390/biomedicines13030659 - 7 Mar 2025
Viewed by 1184
Abstract
Background/Objectives: Meningiomas are the most common intracranial tumors. Surgery and radiation therapy are the cornerstones of treatment and no standard of care therapy exists for refractory meningiomas. This manuscript aims to provide a comprehensive review of novel diagnostic and therapeutic approaches against [...] Read more.
Background/Objectives: Meningiomas are the most common intracranial tumors. Surgery and radiation therapy are the cornerstones of treatment and no standard of care therapy exists for refractory meningiomas. This manuscript aims to provide a comprehensive review of novel diagnostic and therapeutic approaches against these tumors. Methods: A search for the existing literature on systemic therapies for meningiomas was performed on PubMed and a search for presently accruing clinical trials was performed on ClinicalTrials.gov. Results: Systemic treatments, including chemotherapy, somatostatin analogs, anti-hormone therapy, and anti-angiogenic therapy, have been extensively studied with marginal success. Targeted therapies are actively being studied for the treatment of meningiomas, including focal adhesion kinase (FAK), sonic hedgehog signaling pathway, phosphoinositide-3-kinase (PI3K), and cyclin-dependent kinases (CDK) inhibitors. These driver mutations are present only in a subset of meningiomas. In stark contrast, somatostatin receptor 2 (SSTR2) is ubiquitously expressed in meningiomas and was formerly targeted with somatostatin analogs with modest success. Theranostic SSTR2-targeting via [68Ga]DOTATATE for PET imaging and β-emitting [177Lu]DOTATATE for the treatment of meningiomas are currently under active investigation. Conclusions: A nuanced approach is needed for the treatment of refractory meningiomas. Targeted therapies show promise. Full article
(This article belongs to the Special Issue Meningioma: Novel Diagnostic and Therapeutic Approaches)
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