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Biomedicines
Special Issues
High-Risk Pregnancy, Labor and Delivery
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High-Risk Pregnancy, Labor and Delivery

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 4245

Special Issue Editor

Dr. Salvatore Andrea Mastrolia

E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, Ospedale Madonna delle Grazie, Matera, Italy
Interests: great obstetrical syndromes; IUGR; pre-eclampsia; placental abruption; fetal demise; pPROM; gestational diabetes; recurrent abortion
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

High-risk pregnancy involves a variety of clinical and molecular factors, posing a serious threat to maternal and infant safety. During labor and delivery, high-risk pregnant women and fetuses may face higher risks, such as premature birth, fetal distress, and malformations.

Clinically, through systematic screening and comprehensive evaluation, high-risk pregnancy factors such as age, medical history, complications, etc. can be identified as early as possible, and corresponding measures can be taken to intervene. Molecular-level research has explored the pathogenesis of high-risk pregnancy, such as hormone imbalance and gene mutation, and provided new ideas for clinical diagnosis and treatment.

Through comprehensive clinical and molecular-level research, we can better understand and respond to high-risk pregnancies, reduce maternal and infant risks, and improve delivery safety.

Dr. Salvatore Andrea Mastrolia
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • preterm labor
  • labor
  • delivery
  • pregnancy

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Published Papers (2 papers)

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Research

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11 pages, 1007 KiB  
Article
Carbetocin Is More Effective in Stabilizing Hemodynamic Parameters Compared to Oxytocin During Cesarean Section
by Edyta Zagrodnik, Maciej Ziętek, Tomasz Machałowski, Barbara Dołęgowska and Małgorzata Szczuko
Biomedicines 2025, 13(3), 685; https://doi.org/10.3390/biomedicines13030685 - 11 Mar 2025
Viewed by 658
Abstract
Background/Objectives: First-line uterotonics include carbetocin and oxytocin, which act on the oxytocin receptor with varying potencies. Methods: In 70 pregnant Caucasian women who delivered by cesarean section, the effects of oxytocin and carbetocin on heart rate and blood pressure were compared. [...] Read more.
Background/Objectives: First-line uterotonics include carbetocin and oxytocin, which act on the oxytocin receptor with varying potencies. Methods: In 70 pregnant Caucasian women who delivered by cesarean section, the effects of oxytocin and carbetocin on heart rate and blood pressure were compared. The pregnant women were divided into two groups: the OXY group, which received intravenous oxytocin 5 IU on an even day of the month, and the CARBE group, which received intravenous carbetocin 100 µg on an odd day of the month. Blood pressure and heart rate were measured noninvasively every 3 min from the beginning of cesarean section until the lower uterine incision, and then at 1, 2, and 3 min after the fetus and placenta were removed and the uterotonic drugs were discontinued. Subsequent measurements were taken at 3 min intervals until the end of the cesarean procedure. Results: After the administration of uterotonic drugs, a significant decrease in systolic blood pressure was observed only in the group receiving oxytocin at the first (p < 0.0001) and second minute after drug administration (p < 0.0001). Diastolic arterial pressure was significantly different in the study groups at the sixth minute after oxytocin and carbetocin administration (p = 0.004). Mean arterial pressure values were significantly different in the two study groups at the first and sixth minute after drug administration (p = 0.006; p = 0.014). With regard to heart rate, significant differences between the groups were found at 6 min after uterotonic drug administration (p = 0.019). Conclusions: Blood pressure and heart rate variability are significantly higher after oxytocin than after carbetocin administration in women delivering by cesarean section. Full article
(This article belongs to the Special Issue High-Risk Pregnancy, Labor and Delivery)
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Review

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21 pages, 706 KiB  
Review
The Fetal Effect of Maternal Caffeine Consumption During Pregnancy—A Review
by Rajani Dube, Subhranshu Sekhar Kar, Shadha Nasser Mohammed Bahutair, Manjunatha Goud Bellary Kuruba, Shehla Shafi, Huma Zaidi, Heena Chaitanya Garg, Yumna Mushrmita Almas, Alweena Kidwai, Reem Ashraf Fathy Zalat and Omnia Elrasheid Babikir Sidahmed
Biomedicines 2025, 13(2), 390; https://doi.org/10.3390/biomedicines13020390 - 6 Feb 2025
Viewed by 3606
Abstract
Caffeine is commonly used to excess by the general public, and most pregnant women drink caffeine on a daily basis, which can become a habit. Maternal caffeine intake during pregnancy is associated with severe gestational outcomes. Due to its lipophilic nature, caffeine can [...] Read more.
Caffeine is commonly used to excess by the general public, and most pregnant women drink caffeine on a daily basis, which can become a habit. Maternal caffeine intake during pregnancy is associated with severe gestational outcomes. Due to its lipophilic nature, caffeine can cross the blood–brain barrier, placental barrier, and even amniotic fluid. It can be found in substantive amounts in breast milk and semen. There has been a reported drop in neonatal anthropometric measurements with increased caffeine consumption in some cohort studies. This narrative review using literature titles and abstracts from the electronic databases of PubMed, Embase, and Scopus investigates the data linking maternal caffeine use to unfavorable pregnancy outcomes. It also evaluates the validity of the recommendations made by health professionals on caffeine consumption by mothers from the available literature. The results of our comprehensive literature search of case–control studies, cohort studies, randomized control trials, and meta-analyses, imply that caffeine use during pregnancy is linked to miscarriage, stillbirth, low birth weight, and babies that are small for gestational age. It was also found that there may be effects on the neurodevelopment of the child and links to obesity and acute leukemia. These effects can even be seen at doses well below the daily advised limit of 200 mg. The genetic variations in caffeine metabolism and epigenetic changes may play a role in the differential response to caffeine doses. It is crucial that women obtain solid, evidence-based guidance regarding the possible risks associated with caffeine. Full article
(This article belongs to the Special Issue High-Risk Pregnancy, Labor and Delivery)
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