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Biomedicines
Special Issues
Lipids and Lipid Metabolism in Cardiovascular Health and Disease
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Lipids and Lipid Metabolism in Cardiovascular Health and Disease

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 1528

Special Issue Editor

Dr. Fei Luo

E-Mail Website
Guest Editor
Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, China
Interests: lipids; lipid metabolism; cardiovascular health and disease

Special Issue Information

Dear Colleagues,

We are excited to announce an upcoming Special Issue of Biomedicines, entitled "Lipids and Lipid Metabolism in Cardiovascular Health and Disease". This Special Issue aims to focus on the intricate relationship between lipid metabolism and cardiovascular health. It aims to explore the following specific areas:

Molecular Mechanisms: Research on the molecular mechanisms that regulate lipid metabolism and how they impact cardiovascular diseases like coronary artery disease, atrial fibrillation, and hypertension.

Link with Cardiovascular Conditions: Studies investigating the association between lipid profiles (e.g., cholesterol levels) and specific cardiovascular conditions, such as the role of lipids in the pathogenesis and progression of these diseases.

Therapeutic Approaches: Evaluation of novel therapeutic approaches in managing lipid metabolism to enhance cardiovascular outcomes. This may include exploring new medications, lifestyle interventions, or dietary strategies for improving lipid profiles and reducing cardiovascular risk.

Clinical Implications: Discussion on the clinical implications of understanding lipid metabolism in the context of cardiovascular diseases, emphasizing how this knowledge can be translated into personalized treatment strategies and risk assessment for patients.

Preventive Strategies: Exploration of preventive measures targeting lipid metabolism to prevent the development or progression of cardiovascular diseases, highlighting the importance of early intervention and risk factor management.

Emerging Research: Presentation of cutting-edge research on lipid metabolism and cardiovascular health, showcasing advancements in the field and potential future directions for research and clinical practice.

By delving into these specific areas, this Special Issue aims to provide a comprehensive overview of the role of lipids in cardiovascular health and disease, offering valuable insights for researchers, healthcare professionals, and stakeholders in the field.

By joining us in this endeavor, you will have the opportunity to share your latest findings, insights, and innovations with a global audience of researchers, clinicians, and healthcare professionals. Your contributions will advance our understanding of the pivotal role of lipid metabolism in cardiovascular health and disease, paving the way for improved strategies in prevention, diagnosis, and treatment.

We eagerly await your submissions to make this Special Issue a comprehensive and enlightening compilation of cutting-edge research in the field of lipids and cardiovascular health. Together, let us pave the way towards better cardiovascular care through the exploration of lipid metabolism.

Dr. Fei Luo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lipids
  • lipoproteins
  • lipid metabolism
  • cardiovascular health and disease
  • atherosclerotic cardiovascular disease
  • lipid-lowering therapy
  • triglyceride-lowering therapy

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Published Papers (1 paper)

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Research

16 pages, 670 KiB  
Article
Blood Lipid Polygenic Risk Score Development and Application for Atherosclerosis Ultrasound Parameters
by Marija Zaicenoka, Alexandra I. Ershova, Anna V. Kiseleva, Anastasia V. Blokhina, Vladimir A. Kutsenko, Evgeniia A. Sotnikova, Anastasia A. Zharikova, Yuri V. Vyatkin, Maria S. Pokrovskaya, Svetlana A. Shalnova, Vasily E. Ramensky, Alexey N. Meshkov and Oxana M. Drapkina
Biomedicines 2024, 12(12), 2798; https://doi.org/10.3390/biomedicines12122798 - 10 Dec 2024
Viewed by 924
Abstract
Background: The present study investigates the feasibility of using three previously published genome-wide association studies (GWAS) results on blood lipids to develop polygenic risk scores (PRS) for population samples from the European part of the Russian Federation. Methods: Two population samples were used [...] Read more.
Background: The present study investigates the feasibility of using three previously published genome-wide association studies (GWAS) results on blood lipids to develop polygenic risk scores (PRS) for population samples from the European part of the Russian Federation. Methods: Two population samples were used in the study – one from the Ivanovo region (n = 1673) and one from the Vologda region (n = 817). We investigated three distinct approaches to PRS development: using the straightforward PRS approach with original effect sizes and fine-tuning with PRSice-2 and LDpred2. Results: In total, we constructed 56 PRS scales related to four lipid phenotypes: low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, total cholesterol, and triglyceride levels. Compared with previous results for the Russian population, we achieved an additional R2 increase of 2–4%, depending on the approach and lipid phenotype studied. Overall, the R2 PRS estimates approached those described for other populations. We also evaluated the clinical utility of blood lipid PRS for predicting carotid and femoral artery atherosclerosis. Specifically, we found that PRS for total cholesterol, low-density lipoprotein cholesterol, and triglycerides were positively correlated with ultrasound parameters of carotid and femoral artery atherosclerosis (ρ = 0.09–0.13, p < 0.001), whereas PRS for high-density lipoprotein cholesterol were inversely correlated with the number of plaques in the femoral arteries (ρ = −0.08, p = 8.71 × 10−3). Conclusions: PRS fine-tuning using PRSice-2 add LDpred2 improves the performance of blood lipid PRS. Our study demonstrates the potential for further use of blood lipid PRS for prediction of atherosclerosis risk. Full article
(This article belongs to the Special Issue Lipids and Lipid Metabolism in Cardiovascular Health and Disease)
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