Mitochondrial Dysfunction and Oxidative Stress

Dear Colleagues,

Mitochondria, special double-membrane-bound intracellular organelles found in the cells of most eukaryotes, are universally regarded as the powerhouse of the cell. However, in addition to supplying energy, mitochondria fulfill several other roles that contribute to the regulation of the cell’s proper function, as is the case of reactive oxygen species (ROS) formation and neutralization. Having a recognized role as signaling molecules, ROS, when in excessive levels, elicit an imbalance in cellular redox status, leading to a condition of oxidative stress that can cause damage to organelles, including mitochondria itself, as well as tissues and organs in the body. resulting in a vast number of diseases. As many lines of evidence suggest, perturbations in mitochondria physiological function, energy metabolism regulation and oxidative status are critically linked with the pathophysiology of many neurodevelopmental, neuropsychiatric, and neurodegenerative disorders.

Considering the importance of the subject, this Special Issue intends to collect basic and preclinical studies that may cover all research aspects related to mitochondria homeostasis and deregulation, metabolic disturbances, as well as redox biology and its interplay with diverse brain pathologies that impact the human organism from birth to old age. Comprehensive and critical reviews within the topic are also welcome. 

Dr. Susana Cardoso
Guest Editor

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• mitochondria
• oxidative stress
• brain metabolism
• neurodevelopmental diseases
• neuropsychiatric diseases
• neurodegenerative diseases
• mitochondrial medicine
• translational medicine

• Mitochondria and Brain Disease 2.0 in Biomedicines (5 articles)