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Biomedicines
Special Issues
Pathogenesis, Diagnosis and Treatment of Infectious Diseases
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Pathogenesis, Diagnosis and Treatment of Infectious Diseases

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 285

Special Issue Editor

Dr. Laura Franza

E-Mail Website
Guest Editor
Department of Emergency Medicine, Fondazione Policlinico Universitario, Università Cattolica del Sacro Cuore, 00168 Rome, Italy
Interests: inflammation; microbiota; immunology; sepsis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Infectious diseases are a major global health challenge, in particular in a modern world that face challenges of emerging pathogens, antimicrobial resistance, and evolving epidemiological patterns.

This special issue of Biomedicines aims to provide a comprehensive exploration of the mechanisms underlying infectious diseases, novel diagnostic approaches, and cutting-edge therapeutic strategies.

We welcome contributions that enhance our understanding of microbial pathogenesis, host immune responses, and pathogen-host interactions. Submissions focusing on innovative diagnostic techniques, including molecular, immunological, and imaging-based methods, research on antimicrobial agents, novel drug delivery systems, vaccine development, and personalized treatment strategies are all encouraged. Papers exploring the evolving epidemiology of infective diseases, particularly considering the role of underlying chronic diseases, a very important topic in our aging society, will also be gladly considered. We also hope to receive submission concerning changing epidemiology and novel microbial pathogens emerging in the context of climate change.

By bringing together research and reviews from experts in microbiology, immunology, clinical medicine, and biomedical sciences, this special issue aims to advance knowledge and improve outcomes in the fight against infectious diseases.

Dr. Laura Franza
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • infection
  • infectious diseases
  • vaccination
  • antibiotics
  • antibiotic resistance
  • novel therapies
  • novel diagnosis
  • inflammaging
  • immunosenescence

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Review

34 pages, 2107 KiB  
Review
Multidrug-Resistant Infections and Metabolic Syndrome: An Overlooked Bidirectional Relationship
by Carlo Acierno, Riccardo Nevola, Fannia Barletta, Luca Rinaldi, Ferdinando Carlo Sasso, Luigi Elio Adinolfi and Alfredo Caturano
Biomedicines 2025, 13(6), 1343; https://doi.org/10.3390/biomedicines13061343 - 30 May 2025
Abstract
Over the past two decades, metabolic syndrome (MetS) and infections caused by multidrug-resistant (MDR) pathogens have emerged as converging global health challenges. Traditionally investigated as separate entities, accumulating evidence increasingly supports a bidirectional relationship between them, mediated by chronic inflammation, immune dysregulation, gut [...] Read more.
Over the past two decades, metabolic syndrome (MetS) and infections caused by multidrug-resistant (MDR) pathogens have emerged as converging global health challenges. Traditionally investigated as separate entities, accumulating evidence increasingly supports a bidirectional relationship between them, mediated by chronic inflammation, immune dysregulation, gut microbiota alterations, and antibiotic-driven expansion of the resistome. This narrative review examines the complex immunometabolic interplay linking MetS and MDR infections, focusing on molecular mechanisms, clinical implications, and prospective research directions. A systematic literature search was conducted using major databases, including PubMed and Scopus, targeting studies from the last 15 years that explore the interface between metabolic dysfunction and antimicrobial resistance. Particular attention is given to key immunometabolic pathways such as the IRS–PI3K–AKT–mTOR axis; the contribution of visceral adiposity and Toll-like receptor (TLR)-mediated inflammation; and the role of gut dysbiosis in augmenting both susceptibility to infections and metabolic derangements. Evidence is presented supporting the hypothesis that MetS increases host vulnerability to MDR pathogens, while chronic MDR infections may reciprocally induce systemic metabolic reprogramming. Viral infections with established metabolic sequelae (e.g., HIV, hepatitis C virus [HCV], and cytomegalovirus [CMV]) are also considered to broaden the conceptual framework. Although current data remain largely associative and fragmented, the emerging MetS–MDR syndemic model poses substantial challenges for translational research, antimicrobial stewardship, and personalized therapeutic strategies. Recognizing this reciprocal relationship is pivotal for refining infection risk stratification, optimizing treatment, and informing public health policies. Further investigations are warranted to elucidate the magnitude and directionality of this association and to identify predictive immunometabolic biomarkers that may guide targeted interventions in high-risk populations. Full article
(This article belongs to the Special Issue Pathogenesis, Diagnosis and Treatment of Infectious Diseases)
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