Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.2
3.9
Journals
Biomedicines
Special Issues
Cellular and Molecular Mechanisms in Gastrointestinal Tract Disease
share announcement

Cellular and Molecular Mechanisms in Gastrointestinal Tract Disease

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".

Deadline for manuscript submissions: 31 January 2025 | Viewed by 2470

Special Issue Editor

Dr. Felipe Leite De Oliveira

E-Mail Website
Guest Editor
Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil
Interests: gastroenterology; gastrointestinal diseases; cancer; mucosal inflammation

Special Issue Information

Dear Colleagues,

Diseases of the gastrointestinal tract encompass a wide range of disorders that affect the digestive system, and they have attracted the attention of researchers and health professionals around the world. The cellular and molecular mechanisms underlying these diseases, such as inflammatory bowel diseases, irritable bowel syndrome, gastroesophageal reflux, peptic ulcer, celiac disease, gastrointestinal motility disorders, liver diseases, and others, are diverse and involve various components of the gastrointestinal tract. Papers addressing gastrointestinal comorbidities are also welcome in this Special Issue. Cell targets are present in the epithelial barriers, mucosal tissues, accessory glands, immune system, enteric nervous system, neuromuscular junctions, and others. Molecular signaling includes mechanisms that regulate inflammation (cytokines and chemokines), fibrosis, aberrant immune responses, genetic susceptibility, abnormalities in the gut–brain axis, visceral hypersensitivity, pathogens, disruption of mucosa, cancer, smooth muscle abnormalities, and others. Understanding these cellular and molecular mechanisms is crucial for developing targeted therapies, diagnostic tools, and interventions for the diverse array of gastrointestinal diseases resulting in precision medicine and personalized treatment approaches. Studies in this area involve the oral cavity, esophagus, stomach, small and large intestines, salivary glands, liver, pancreas, and gallbladder. This Special Issue aims to improve both preventive and therapeutic protocols and methodologies for precision diagnosis. Advances in molecular and cell biology in gastrointestinal diseases continue to enhance our understanding of these mechanisms and drive innovation in medical research and healthcare. Papers on other topics linked to gastrointestinal tract diseases not included here, however, will also be considered by the editorial team.

Dr. Felipe Leite De Oliveira
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cellular mechanisms
  • molecular mechanisms
  • diagnosis
  • treatment
  • experimental models
  • signaling pathways
  • comorbidities

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

20 pages, 6161 KiB  
Article
First Application of a Mixed Porcine–Human Repopulated Bioengineered Liver in a Preclinical Model of Post-Resection Liver Failure
by Philipp Felgendreff, Seyed Mohammad Hosseiniasl, Anna Minshew, Bruce P. Amiot, Silvana Wilken, Boyukkhanim Ahmadzada, Robert C. Huebert, Nidhi Jalan Sakrikar, Noah G. Engles, Peggy Halsten, Kendra Mariakis, John Barry, Shawn Riesgraf, Chris Fecteau, Jeffrey J. Ross and Scott L. Nyberg
Biomedicines 2024, 12(6), 1272; https://doi.org/10.3390/biomedicines12061272 - 7 Jun 2024
Viewed by 754
Abstract
In this study, a mixed porcine–human bioengineered liver (MPH-BEL) was used in a preclinical setup of extracorporeal liver support devices as a treatment for a model of post-resection liver failure (PRLF). The potential for human clinical application is further illustrated by comparing the [...] Read more.
In this study, a mixed porcine–human bioengineered liver (MPH-BEL) was used in a preclinical setup of extracorporeal liver support devices as a treatment for a model of post-resection liver failure (PRLF). The potential for human clinical application is further illustrated by comparing the functional capacity of MPH-BEL grafts as assessed using this porcine PRLF model with fully human (FH-BEL) grafts which were perfused and assessed in vitro. BEL grafts were produced by reseeding liver scaffolds with HUVEC and primary porcine hepatocytes (MPH-BEL) or primary human hepatocytes (FH-BEL). PRLF was induced by performing an 85% liver resection in domestic white pigs and randomized into the following three groups 24 h after resection: standard medical therapy (SMT) alone, SMT + extracorporeal circuit (ECC), and SMT + MPH-BEL. The detoxification and metabolic functions of the MPH-BEL grafts were compared to FH-BEL grafts which were perfused in vitro. During the 24 h treatment interval, INR values normalized within 18 h in the MPH-BEL therapy group and urea synthesis increased as compared to the SMT and SMT + ECC control groups. The MPH-BEL treatment was associated with more rapid decline in hematocrit and platelet count compared to both control groups. Histological analysis demonstrated platelet sequestration in the MPH-BEL grafts, possibly related to immune activation. Significantly higher rates of ammonia clearance and metabolic function were observed in the FH-BEL grafts perfused in vitro than in the MPH-BEL grafts. The MPH-BEL treatment was associated with improved markers of liver function in PRLF. Further improvement in liver function in the BEL grafts was observed by seeding the biomatrix with human hepatocytes. Methods to reduce platelet sequestration within BEL grafts is an area of ongoing research. Full article
(This article belongs to the Special Issue Cellular and Molecular Mechanisms in Gastrointestinal Tract Disease)
►▼ Show Figures

Figure 1

Review

Jump to: Research

22 pages, 3709 KiB  
Review
Unraveling Chylomicron Retention Disease Enhances Insight into SAR1B GTPase Functions and Mechanisms of Actions, While Shedding Light of Intracellular Chylomicron Trafficking
by Emile Levy, Catherine Fallet-Bianco, Nickolas Auclair, Natalie Patey, Valérie Marcil, Alain Théophile Sané and Schohraya Spahis
Biomedicines 2024, 12(7), 1548; https://doi.org/10.3390/biomedicines12071548 - 12 Jul 2024
Viewed by 429
Abstract
Over the past three decades, significant efforts have been focused on unraveling congenital intestinal disorders that disrupt the absorption of dietary lipids and fat-soluble vitamins. The primary goal has been to gain deeper insights into intra-enterocyte sites, molecular steps, and crucial proteins/regulatory pathways [...] Read more.
Over the past three decades, significant efforts have been focused on unraveling congenital intestinal disorders that disrupt the absorption of dietary lipids and fat-soluble vitamins. The primary goal has been to gain deeper insights into intra-enterocyte sites, molecular steps, and crucial proteins/regulatory pathways involved, while simultaneously identifying novel therapeutic targets and diagnostic tools. This research not only delves into specific and rare malabsorptive conditions, such as chylomicron retention disease (CRD), but also contributes to our understanding of normal physiology through the utilization of cutting-edge cellular and animal models alongside advanced research methodologies. This review elucidates how modern techniques have facilitated the decoding of CRD gene defects, the identification of dysfunctional cellular processes, disease regulatory mechanisms, and the essential role of coat protein complex II-coated vesicles and cargo receptors in chylomicron trafficking and endoplasmic reticulum (ER) exit sites. Moreover, experimental approaches have shed light on the multifaceted functions of SAR1B GTPase, wherein loss-of-function mutations not only predispose individuals to CRD but also exacerbate oxidative stress, inflammation, and ER stress, potentially contributing to clinical complications associated with CRD. In addition to dissecting the primary disease pathology, genetically modified animal models have emerged as invaluable assets in exploring various ancillary aspects, including responses to environmental challenges such as dietary alterations, gender-specific disparities in disease onset and progression, and embryonic lethality or developmental abnormalities. In summary, this comprehensive review provides an in-depth and contemporary analysis of CRD, offering a meticulous examination of the CRD current landscape by synthesizing the latest research findings and advancements in the field. Full article
(This article belongs to the Special Issue Cellular and Molecular Mechanisms in Gastrointestinal Tract Disease)
►▼ Show Figures

Figure 1

13 pages, 1605 KiB  
Review
Progastrin: An Overview of Its Crucial Role in the Tumorigenesis of Gastrointestinal Cancers
by Rodanthi Fioretzaki, Panagiotis Sarantis, Nikolaos Charalampakis, Konstantinos Christofidis, Adam Mylonakis, Evangelos Koustas, Michalis V. Karamouzis, Stratigoula Sakellariou and Dimitrios Schizas
Biomedicines 2024, 12(4), 885; https://doi.org/10.3390/biomedicines12040885 - 17 Apr 2024
Viewed by 918
Abstract
Defining predictive biomarkers for targeted therapies and optimizing anti-tumor immune response is a main challenge in ongoing investigations. Progastrin has been studied as a potential biomarker for detecting and diagnosing various malignancies, and its secretion has been associated with cell proliferation in the [...] Read more.
Defining predictive biomarkers for targeted therapies and optimizing anti-tumor immune response is a main challenge in ongoing investigations. Progastrin has been studied as a potential biomarker for detecting and diagnosing various malignancies, and its secretion has been associated with cell proliferation in the gastrointestinal tract that may promote tumorigenesis. Progastrin is a precursor molecule of gastrin, synthesized as pre-progastrin, converted to progastrin after cleavage, and transformed into amidated gastrin via biosynthetic intermediates. In cancer, progastrin does not maturate in gastrin and becomes a circulating and detectable protein (hPG80). The development of cancer is thought to be dependent on the progressive dysregulation of normal signaling pathways involved in cell proliferation, thus conferring a growth advantage to the cells. Understanding the interaction between progastrin and the immune system is essential for developing future cancer strategies. To that end, the present review will approach the interlink between gastrointestinal cancers and progastrin by exploring the underlying molecular steps involved in the initiation, evolution, and progression of gastrointestinal cancers. Finally, this review will focus on the clinical applications of progastrin and investigate its possible use as a diagnostic and prognostic tumor circulating biomarker for disease progression and treatment effectiveness, as well as its potential role as an innovative cancer target. Full article
(This article belongs to the Special Issue Cellular and Molecular Mechanisms in Gastrointestinal Tract Disease)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop