Recent Advances in Biomedical Engineering for the Aging Population

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Biomedical Engineering and Materials".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 747

Special Issue Editors


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Guest Editor
National Cheng Kung University Hospital, Tainan, Taiwan
Interests: rehabilitation; geriatrics; tissue engineering; pain medicine

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Guest Editor
Department of Computer Science and Information Engineering, National Yunlin University of Science and Technology, Yunlin, Taiwan
Interests: e-health informatics; bioengineering and biotechnology

Special Issue Information

Dear Colleagues,

This upcoming Special Issue, entitled "Recent Advances in Biomedical Engineering for the Aging Population", aims to feature significant contributions from biomedical engineering, geriatric engineering, and rehabilitation scholars. As the population ages, the application of biomedical engineering in geriatric and rehabilitation clinical settings has become a hot research topic. This Special Issue aims to cover the latest findings in this area. We invite the submission of high-quality research papers or review articles focused on topics such as geriatric engineering, regenerative medicine, cellular senescence, chronic disease modelling, molecular mechanisms, artificial intelligence in healthcare for older adults, bioinformatics of aging-related diseases, rehabilitation engineering, mitochondria in aging, biomedical sensors, and biomedical signal and image processing in the aging population.

Dr. Weichih Lien
Dr. Wen-Fong Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomedical engineering
  • geriatric engineering
  • senescence
  • regenerative medicine
  • rehabilitation

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Published Papers (1 paper)

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Review

18 pages, 1220 KiB  
Review
Heart Rate Variability and Autonomic Dysfunction After Stroke: Prognostic Markers for Recovery
by Sara Lago, Toon T. de Beukelaar, Ilaria Casetta, Giorgio Arcara and Dante Mantini
Biomedicines 2025, 13(7), 1659; https://doi.org/10.3390/biomedicines13071659 - 7 Jul 2025
Viewed by 395
Abstract
Stroke is a major cause of long-term disability and mortality worldwide, often resulting in impairments not only in motor and cognitive functions but also in autonomic nervous system (ANS) regulation. Among the physiological markers that reflect ANS activity, heart rate variability (HRV) has [...] Read more.
Stroke is a major cause of long-term disability and mortality worldwide, often resulting in impairments not only in motor and cognitive functions but also in autonomic nervous system (ANS) regulation. Among the physiological markers that reflect ANS activity, heart rate variability (HRV) has emerged as a promising biomarker for assessing stroke severity and predicting recovery outcomes. HRV quantifies the temporal fluctuations between heartbeats and is traditionally analyzed through time- and frequency-domain measures. More recent approaches have introduced non-linear metrics such as approximate entropy, sample entropy, and detrended fluctuation analysis to capture complex heart rate dynamics. In this narrative review, we address the role of both linear and non-linear HRV parameters in the context of stroke, highlighting their relevance for understanding autonomic dysfunction and guiding rehabilitation. Evidence shows that reduced HRV is associated with poorer functional outcomes, higher mortality, and increased risk of complications post-stroke. Moreover, HRV trends can provide valuable insights into treatment effectiveness and individual recovery trajectories. We also discuss practical considerations for HRV measurement, including device selection, preprocessing strategies, and the need for methodological standardization. Finally, we outline interventional strategies that may enhance HRV and promote better recovery. Together, these findings support the integration of HRV analysis into stroke care as a non-invasive, accessible tool to guide prognosis and tailor interventions. Full article
(This article belongs to the Special Issue Recent Advances in Biomedical Engineering for the Aging Population)
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