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Bioengineering publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Application of Laser Therapy in Oral Diseases: Second Edition

edited by

Ivona Bago

and Ivana Vidović Zdrilić

submission deadline 31 Oct 2025 | Viewed by 59 | Submission Open

Keywords: laser therapy; low-level laser therapy; photobiomodulation; oral diseases; laser parameters

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Bio‑Derived Materials for Electrochemical Energy and Environmental Systems

edited by

Naoufel Haddour

submission deadline 31 Oct 2025 | Viewed by 58 | Submission Open

Keywords: bio‑sourced materials; biomass‑derived carbon; biopolymers; microbial fuel cells; supercapacitors; sustainable batteries; biochar electrodes; bio‑inspired catalysis

(This special issue belongs to the Section Biochemical Engineering)

Applications of 3D Bioprinting Technology in Cancer Research

edited by

Aranzazu Villasante

submission deadline 31 Oct 2025 | Viewed by 55 | Submission Open

Keywords: 3D bioprinting; cancer models; tumor microenvironment; tissue engineering; personalized medicine

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Artificial Intelligence in Cardio-Oncology and Cardiovascular Health

edited by Sherry Ann Brown

submission deadline 31 Oct 2025 | Viewed by 51 | Submission Open

Keywords: artificial intelligence; cardio-oncology; cardiovascular health; machine learning; personalized medicine; cardiovascular toxicity

(This special issue belongs to the Section Biosignal Processing)

Artificial Intelligence for Better Healthcare and Precision Medicine, 2nd Edition

edited by Yu Tian

submission deadline 31 Oct 2025 | Viewed by 42 | Submission Open

Keywords: artificial intelligence; healthcare; precision medicine; disease diagnosis; prognosis; drug discovery; personalized treatment selection; healthcare resource management; large language models

(This special issue belongs to the Section Biosignal Processing)

Stem Cell Engineering and Tissue Regeneration

edited by Bo Wang and

Shue Wang

submission deadline 1 Nov 2025 | Viewed by 343 | Submission Open

Keywords: stem cells; tissue engineering; biomaterial; drug delivery; clinical translation

(This special issue belongs to the Section Regenerative Engineering)

Innovative Biomaterials and Advanced Technologies in Bone Tissue Regeneration

edited by

Natalia Di Pietro

submission deadline 1 Nov 2025 | 1 articles | Viewed by 336 | Submission Open

Keywords: biomaterials; bone tissue regeneration; tissue engineering; scaffolds; prosthetics; dental implants; osseointegration; numerical studies; biomechanics; digital dentistry

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Nano-Based Drug Delivery System: Recent Developments and Future Prospects, Second Edition

edited by

Nitin Charbe

and

Venkata Krishna Kowthavarapu

submission deadline 10 Nov 2025 | Viewed by 37 | Submission Open

Keywords: nanomedicine; polymeric nanoparticles; siRNA delivery; mRNA delivery; lipid-based drug delivery systems; liposomes; targeted drug delivery systems; nanotherapeutics; biomaterials

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

Innovations in Biomaterials for Advanced Biomedical Applications

edited by

Muhammad Zubair

and

Aman Ullah

submission deadline 15 Nov 2025 | 1 articles | Viewed by 1160 | Submission Open

Keywords: biomaterials; cancer treatment; wound care; cancer therapy; nanomedicine; drug delivery; tumor targeting; biocompatible materials; theranostics; immunotherapy; drug-release systems

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Machine Learning-Driven Innovations in Biomedical Signal and Image Processing

edited by

Luis Coelho

João Paulo Ramos Teixeira

and

João Paulo Pereira do Carmo

submission deadline 15 Nov 2025 | Viewed by 302 | Submission Open

Keywords: signal processing; image processing; machine learning

(This special issue belongs to the Section Biosignal Processing)

Fundamentals and Novel Applications of Fluid Mechanics, Biomechanics, and Acoustics in Biomedical Engineering, 2nd Edition

edited by

Iris Little

and

Ephraim Gutmark

submission deadline 20 Nov 2025 | 3 articles | Viewed by 2590 | Submission Open

Keywords: hemodynamics; cardiovascular flow; sleep; airway; voice; bioacoustics; biomechanics; bioflows; CFD; FSI; AI; ML

Artificial Intelligence in Biotechnology

edited by Mohammad (Behdad) Jamshidi and Omid Moztarzadeh

submission deadline 20 Nov 2025 | Viewed by 68 | Submission Open

Keywords: artificial intelligence (AI); biotechnology; machine learning; deep learning; digital twins; multi-omics integration; cancer diagnostics; synthetic biology; internet of bio-nano things (IoBNT); drug discovery

(This special issue belongs to the Section Biosignal Processing)

Next-Generation Neurodiagnostics: Deep Learning, Hyperspectral Imaging, and Computing Acceleration in Brain Condition Detection

edited by

Miguel Chavarrías

César Sanz

and Jaime Sancho

submission deadline 25 Nov 2025 | Viewed by 47 | Submission Open

Keywords: hyperspectral imaging; multimodal imaging; neurodiagnostics; deep learning; machine learning; accelerated computing

(This special issue belongs to the Section Biosignal Processing)

Recent Advances in Machine Learning and Explainable Artificial Intelligence in Biomedical Data Mining, and Disease Diagnosis Frameworks

edited by

Amad Zafar

submission deadline 30 Nov 2025 | 9 articles | Viewed by 16393 | Submission Open

Keywords: EEG; fNIRS; MRI; X-rays; biomedical signal and image processing; machine learning; explainable artificial intelligence; biomedical data mining; computer-aided diagnosis; brain– computer interfaces; healthcare

(This special issue belongs to the Section Biosignal Processing)

Spine Biomechanics

edited by Christian Liebsch

submission deadline 30 Nov 2025 | 11 articles | Viewed by 10546 | Submission Open

Keywords: biomechanics; spine; intervertebral disc; experiment; modeling; in vivo; in vitro; in silico

(This special issue belongs to the Section Biomechanics and Sports Medicine)

Joint Biomechanics and Implant Design

edited by Ryan Willing and

Ryan Chapman

submission deadline 30 Nov 2025 | 10 articles | Viewed by 10117 | Submission Open

Keywords: orthopedics; sports medicine; arthroplasty; prosthesis design; finite element analysis; joint motion simulators; imaging; contact mechanics; instability; loosening

(This special issue belongs to the Section Biomechanics and Sports Medicine)

Biomedical Applications of Optical Coherence Tomography, Second Edition

edited by Shintaro Horie

submission deadline 30 Nov 2025 | 5 articles | Viewed by 8892 | Submission Open

Keywords: retinal imaging; optical coherence tomography; optics; biophotonics

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Artificial Intelligence Revolution in Biomedical Image and Signal Processing: Innovations and Applications

edited by

Shih-Lun Chen

Liang-Hung Wang

and Tsung-Yi Chen

submission deadline 30 Nov 2025 | 3 articles | Viewed by 3829 | Submission Open

Keywords: artificial intelligence techniques for biomedical signal and image processing; medical image processing; deep learning; AI-based diagnostic imaging; multimodal image fusion; early disease detection; image-guided surgery

(This special issue belongs to the Section Biosignal Processing)

Advancements in Biocompatible Materials for Implantable Medical Devices

edited by

Tarun Goswami

and

Farah Hamandi

submission deadline 30 Nov 2025 | 1 articles | Viewed by 3699 | Submission Open

Keywords: biomaterials; clinical engineering; biomedical devices; cardiovascular engineering; biomedical instrumentation; biomechanical engineering; biomedical modeling; biomedical technology

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Machine Learning Methods for Biomedical Imaging

edited by Lei Qiu, Yibo Xie and Suk Whan Yoon

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2643 | Submission Open

Keywords: AI; machine learning; deep learning; biomedical image analysis

(This special issue belongs to the Section Biosignal Processing)

Blue Economy: Innovative Strategies for Valorising Micro- and Macroalgae

edited by

José Carlos Magalhães Pires

and Tânia Tavares

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2599 | Submission Open

Keywords: blue economy; microalgae; microscopic aquatic plants; macroalgae; valuable compounds

(This special issue belongs to the Section Biochemical Engineering)

Preclinical Evaluation of Biomaterials and Medical Devices for the Musculoskeletal System

edited by

Silvia Brogini

and Matilde Tschon

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2402 | Submission Open

Keywords: biomaterials and medical devices; preclinical testing; humanized advanced in vitro models; orthopaedic applications

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Artificial Intelligence in Biomedical Imaging, Biosignals and Healthcare

edited by

Ioannis Kakkos

and

George K. Matsopoulos

submission deadline 30 Nov 2025 | 3 articles | Viewed by 2161 | Submission Open

Keywords: biomedical data processing; artificial intelligence in healthcare; medical image segmentation; predictive modeling in medicine; machine learning in diagnostics; personalized treatment planning; quantitative image analysis; AI-driven medical imaging; computational modeling in healthcare; real-time AI applications in medicine

(This special issue belongs to the Section Biosignal Processing)

Biomechanics in Sport and Motion Analysis

edited by

Kamran Iqbal

and

Rajat Emanuel Singh

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2014 | Submission Open

Keywords: biomechanics; sports science; human motion; artificial intelligence

(This special issue belongs to the Section Biomechanics and Sports Medicine)

Diagnostic Imaging and Radiation Therapy in Biomedical Engineering

edited by

Carlo A. Mallio

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1861 | Submission Open

Keywords: diseases diagnostic; radiation therapy; biomedical engineering; imaging technology

(This special issue belongs to the Section Biosignal Processing)

Bringing Precision Medicine into the Clinical Practice: The Role of Explainable Artificial Intelligence and Interpretable Models

edited by

Nicola Altini

and Gian Maria Zaccaria

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1757 | Submission Open

Keywords: precision medicine; clinical practice; explainable artificial intelligence; interpretable models

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Advances in Medical 3D Vision: Voxels and Beyond

edited by Jiancheng Yang, Hongwei Li and Hieu Le

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1689 | Submission Open

Keywords: medical 3D vision; artificial intelligence for health; 3D medical image analysis; voxel-based imaging; point clouds; mesh-based analysis; graph neural networks; implicit representations; deep geometric learning; interventional imaging; healthcare applications; digital twins

(This special issue belongs to the Section Biosignal Processing)

Pathology–Therapeutics–Medicine of Vascular and Respiratory Diseases: Recent Progress Using CFD and AI

edited by

Hang Yi

and

Jianan Zhao

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1679 | Submission Open

Keywords: biofluids; biomechanics; drug delivery; medical device; pathophysiology; intervention; therapeutics; medicine; hemodynamics; neurovascular and cardiovascular diseases; respiratory airway diseases; computational fluid dynamics; multiphase/multispecies flow modeling; physiologically based pharmacokinetic/toxicokinetic models; machine learning and deep learning in healthcare

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Measuring Outcomes and Impact Related to Assistive Technology and Accessibility for Disability

edited by Rochelle Mendonca, Qussai Obiedat and Roger O. Smith

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1658 | Submission Open

Keywords: assistive technology; disability; accessibility; measurement; outcomes; universal design

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Computer Vision and Machine Learning in Medical Applications, 2nd Edition

edited by

Chunhung Richard Lin

submission deadline 30 Nov 2025 | 3 articles | Viewed by 1483 | Submission Open

Keywords: computer vision; machine learning; medical applications

(This special issue belongs to the Section Biosignal Processing)

Application of Bioengineering to Clinical Orthodontics—2nd Edition

edited by

Zhiyi Shan

and

Yanqi Yang

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1362 | Submission Open

Keywords: biomechanics; biomaterials; tissue engineering; orthodontics; craniofacial regeneration; computer-aided diagnosis; AI used in craniofacial fields

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Extracellular Matrix Biomaterial for Tissue Engineering and Regenerative Medicine

edited by Elizabeth C. Martin and

Jorge Alfonso Belgodere

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1141 | Submission Open

Keywords: extracellular matrix; ECM protein; biomaterials; 3D bioprinting; tissue engineering; regenerative medicine

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Orthopaedic Bioengineering and Tissue Regeneration

edited by

David Putzer

submission deadline 30 Nov 2025 | 2 articles | Viewed by 865 | Submission Open

Keywords: orthopaedic bioengineering; implant surfaces; biological response of implant surfaces; bone remodelling; bioprinted scaffolds

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Advances in Three-Dimensional Culture Systems: Bridging Biology and Medicine

edited by

Fatima A. Merchant

submission deadline 30 Nov 2025 | Viewed by 572 | Submission Open

Keywords: 3D culture platforms; microengineered 3D systems; biomaterials for 3D culture; engineering complex 3D microenvironments; 3D systems for modeling disease and physiological processes; 3D culture-based therapies and diagnostic tools; translation of 3D systems for clinical applications

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

New Insights into Machine Learning and Biomedicine: Updates and Directions, 2nd Edition

edited by

Cǎtǎlina Luca

and

Calin Corciova

submission deadline 30 Nov 2025 | Viewed by 462 | Submission Open

Keywords: machine learning; biomedicine; artificial intelligence; biomedical data analysis; deep learning; clinical decision support; predictive modeling; personalized medicine; bioinformatics; neural networks; explainable AI (XAI); health informatics; omics data integration; data-driven in medicine; AI in healthcare; ethics in AI for medicine; future directions in biomedicine

(This special issue belongs to the Section Biosignal Processing)

Application of Bioengineering to Orthopedics

edited by

Simon Kwoon-ho Chow

and

Stuart Goodman

submission deadline 30 Nov 2025 | Viewed by 184 | Submission Open

Keywords: orthopaedics; biomechanics; biomaterials; tissue engineering; regenerative medicine

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Recent Advances in Cardiac MRI

edited by

Qing Zou

and Gerald Greil

submission deadline 30 Nov 2025 | Viewed by 156 | Submission Open

Keywords: cardiac MRI; post-processing; deep learning; fast imaging; novel sequences

(This special issue belongs to the Section Biosignal Processing)

Advanced 3D Cell Culture Technologies and Formats, 2nd Edition

edited by

Cornelia Kasper

, Dominik Egger and

Isita Sagar

submission deadline 30 Nov 2025 | Viewed by 129 | Submission Open

Keywords: 3D cell culture; bioreactors; tissue engineering

(This special issue belongs to the Section Regenerative Engineering)

Application of Artificial Intelligence in Oncologic PET Imaging

edited by

Angelo Castello

Seyed Ali Mirshahvalad

and

Adam Farag

submission deadline 30 Nov 2025 | 1 articles | Viewed by 100 | Submission Open

Keywords: positron emission tomography (PET); PET/CT; PET/MRI; artificial intelligence; radiomics; machine learning; deep learning; convolutional neural networks; auto-segmentation; quantification; theranostics; novel radiopharmaceuticals

(This special issue belongs to the Section Biosignal Processing)

Nano–Bio Interface—Second Edition

edited by

Zicheng Deng

Donglu Shi

and

Yilong Wang

submission deadline 30 Nov 2025 | Viewed by 83 | Submission Open

Keywords: nanoparticles; nanotoxicology; drug delivery; tissue engineering; diagnostics; environmental health

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

Engineering Mesenchymal Stem Cells for Regenerative Medicine

edited by Kyungsook Kim and

Luis G. Villa-Diaz

submission deadline 30 Nov 2025 | Viewed by 72 | Submission Open

Keywords: mesenchymal stem cell (MSC) engineering; genetic modification of MSCs; MSC biomaterial integration; surface modification of MSCs; MSC sheet engineering; scaffold-free MSC delivery; MSC bioactive factor secretion; direct MSC reprogramming; engineered MSC characterization and differentiation; improved protocols for MSC derivation from tissues and pluripotent; clinical translation strategy of engineered MSCs

(This special issue belongs to the Section Regenerative Engineering)

Advanced Biomedical Signal Communication Technology

edited by

Chin-Feng Lin

submission deadline 30 Nov 2025 | 1 articles | Viewed by 64 | Submission Open

Keywords: advanced biomedical signal communication; advanced biomedical signal analysis and process; medical images; virtual reality; mixed reality; artificial intelligence; encryption; Internet of Medical Things; cloud-based medical communications; healthcare; telemedicine

(This special issue belongs to the Section Biosignal Processing)

New Tools for Multidisciplinary Treatment in Dentistry, 2nd Edition

edited by

Cristina Grippaudo

Raffaella Castagnola

, Paolo Francesco Manicone and Gaetano Isola

submission deadline 30 Nov 2025 | Viewed by 61 | Submission Open

Keywords: dentistry; biomaterials; deep learning; regenerative medicine; 3D imaging; dental materials; artificial intelligence; teledentistry; multidisciplinary; orthodontics; periodontics; dental surgery; dental prosthesis; endodontics; maxillo– facial surgery

(This special issue belongs to the Section Regenerative Engineering)

Machine Learning, Artificial Intelligence and Medicine: The Interface of Medicine, Computer Science and Engineering

edited by Simon W. Rabkin

submission deadline 30 Nov 2025 | Viewed by 52 | Submission Open

Keywords: medical informatics; healthcare analytics; predictive modeling; digital health; precision medicine; machine learning; artificial intelligence

(This special issue belongs to the Section Biosignal Processing)

Bioengineered Approaches to Oral-Systemic Disease Diagnostics and Therapeutics

edited by

João Miguel Marques dos Santos

submission deadline 30 Nov 2025 | Viewed by 51 | Submission Open

Keywords: bioengineering; oral health; systemic diseases; diagnostics; therapeutics; biomarkers

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Generative AI for Biosignal and Medical Imaging Analysis

edited by Wei Peng, Tian Xia, Haoyu Chen and

Yante Li

submission deadline 30 Nov 2025 | Viewed by 47 | Submission Open

Keywords: generative AI; AI for biomedicine; LLM in healthcare; digital health

(This special issue belongs to the Section Biosignal Processing)

Bioengineering Advances in Mobility and Neural Integration

edited by

Nasif Zaman

submission deadline 30 Nov 2025 | Viewed by 47 | Submission Open

Keywords: biomechanics; neural interfaces; mobility restoration; bioelectronic devices; neurotechnology; regenerative medicine; implantable electronics; spinal cord injuries; neurodegenerative diseases

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Advances in Intelligent Health Management and Rehabilitation Technology: Integrating Large Language Models and AI Solutions

edited by Ning Deng

submission deadline 30 Nov 2025 | Viewed by 44 | Submission Open

Keywords: intelligent rehabilitation technology; health monitoring systems; machine learning in healthcare; intelligent nursing technology; proactive health management; large language models in healthcare; AI-assisted clinical decision-making; personalized rehabilitation strategies

(This special issue belongs to the Section Biosignal Processing)

The Use of Artificial Intelligence in Pain Research

edited by