Bioengineering the AAV System: Devices, Quantitative Measurement, and Predictive Models

Dear Colleagues,

Adeno-associated virus (AAV) vectors are complex engineered systems whose performance depends on delivery hardware, quantitative measurement, and model-based control. This Special Issue invites bioengineering work that builds, measures, and predicts AAV behavior in vivo and in bioprocess. We welcome device-assisted delivery (catheters, focused ultrasound, convection-enhanced, microfluidics), standardized biodistribution and potency assays (including barcoded vectors as “sensors”), and quantitative PK/PD and dosimetry models linking route, dose, and tissue exposure to expression. We encourage resources that harmonize assays across labs, open datasets/analysis pipelines, and digital-twin approaches that integrate imaging, omics, and process data. Studies on vector-genome control elements are in scope when framed as engineered circuits with quantitative benchmarks. Submissions should emphasize engineering methodology, validation, and reproducibility.

Dr. Karim Daliri
Prof. Dr. Hua Naranmandura
Guest Editors

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