Bioengineering Cardiovascular Cell and Gene Therapies: Advances and Translational Challenges
A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 137
Special Issue Editors
Interests: atherosclerosis; angiogenesis; myocardial infarction; vascular cell biology; cardiomyocyte biology; microRNA; lncRNA; heart regeneration; epigenetic cardiac reprogramming; iPSC differentiation
Interests: induced pluripotent stem cells; cardiac tissue engineering; cardiac cell therapy; microtissues and organoids
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cardiovascular diseases remain the leading cause of morbidity and mortality worldwide, driving the urgent need for innovative therapeutic strategies. Bioengineering approaches, particularly in cell and gene therapy, hold great promise for advancing cardiovascular regeneration, repair, and disease treatment. Despite significant progress, the clinical translation of these therapies is hindered by challenges in the design of biomaterials, gene delivery, cell sourcing, scalability, and regulatory approval. Addressing these hurdles requires an interdisciplinary effort that integrates bioengineering principles with cutting-edge biomedical research.
This Special Issue, “Bioengineering Cardiovascular Cell and Gene Therapies: Advances and Translational Challenges”, invites researchers to submit original research articles and comprehensive reviews that explore novel bioengineering strategies to improve cardiovascular cell and gene therapies. Topics of interest include, but are not limited to, the following:
Biomaterials and Scaffolds for enhancing the efficacy of cell therapy in cardiovascular applications.
Gene Delivery Systems, including viral and non-viral vectors for targeted cardiovascular repair.
Stem Cell and iPSC Technologies for cardiac and vascular regeneration.
Tissue Engineering and Organoid Models to study cardiovascular disease mechanisms and therapy optimizations.
Microfluidics and Organ-on-a-Chip Models for the preclinical assessment of cardiovascular therapeutics.
The Immunomodulation and Biocompatibility of cell and gene therapies in cardiovascular applications.
Translational Barriers, including manufacturing challenges, clinical trial considerations, and regulatory pathways.
By bringing together contributions from leading researchers in bioengineering, regenerative medicine, and cardiovascular sciences, this Special Issue aims to foster interdisciplinary discussions that accelerate the development of clinically viable cardiovascular therapies.
Dr. Emre Bektik
Dr. Kurt Pfannkuche
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- myocardial infarction
- atherosclerosis
- peripheral artery disease (PAD)
- stem cells differentiation
- iPSCs disease modeling
- biomaterials
- gene delivery
- tissue engineering approaches
- vascular regeneration
- cardiac repair
- CRISPR gene editing
- bio-scaffolds
- bioprinting
- microfluidics
- organ-on-a-chip
- immunomodulation
- exosomes
- drug delivery
- clinical translation
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