Biofabrication of Biologically Realistic Constructs: Needs, Challenges, and Opportunities
A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Nanobiotechnology and Biofabrication".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 71
Special Issue Editor
Special Issue Information
Dear Colleagues,
This Special Issue of Bioengineering, titled "Biofabrication of Biologically Realistic Constructs: Needs, Challenges, and Opportunities", aims to showcase an emerging paradigm shift in tissue engineering from technology-driven developments to biology-driven implementations that prioritize structural and functional fidelity. This Special Issue addresses a current challenge in the field: the disconnect between engineering capabilities and the structure–function paradigm that governs biological systems. We will highlight innovative methods, biomaterials, and technologies—including single-cell manipulation, bioprinting, and advanced imaging—that strive to enable faithful reproduction of biological complexity. Contributors are invited to cover topics such as construct shape fidelity, hierarchical vascularization with lymphatic-like drainage and mural cell integration, strategies for tissue innervation, and microscopic considerations including cellular heterogeneity or organoid-based assembly, etc. The scope of this call for submissions also encompasses applications in regenerative medicine, disease modeling, hybrid bio-inorganic constructs, as well as development of physiologically relevant culture systems for drug and toxicology testing, particularly in response to the need to reduce animal experimentation. By bringing together research articles, reviews, and perspectives, this Special Issue seeks not only to raise awareness, but also to establish benchmarks for biological realism in biofabrication, thus accelerating the transition to clinically relevant, biologically faithful tissue constructs for both in vivo and in vitro applications.
Dr. Nicanor Ilie Moldovan
Guest Editor
Manuscript Submission Information
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Keywords
- biofabrication
- biological realism
- bioprinting
- cell–biomaterial interaction
- tissue engineering
- hybrid constructs
- clinical translation
- in vitro models
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