Biomaterials for the Repair and Regeneration of Musculoskeletal Tissue

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 2288

Special Issue Editor


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Guest Editor
Rubin Institute for Advanced Orthopaedics, International Center for Limb Lengthening, Sinai Hospital of Baltimore, 2401 West Belvedere Avenue, Baltimore, MD 21215, USA
Interests: microsurgical revascularization of bone; autologous & allogeneic heterotopic bone banking; enhanced healing of skin graft donor sites in multimorbid patients with processed human dermal allograft; enhanced tissue healing with cleaved collagen substrates; nerve reconstruction & regeneration

Special Issue Information

Dear Colleagues,

The use of tissue engineering techniques to augment and improve the healing of multiple-organ systems continues to have a tremendous positive impact on patient health. Improved clinical outcomes are often the direct result of advances in tissue engineering, which are made possible by the dedicated efforts of scientists and the creativity and skill of surgeons. Indeed, the limitations of these amazing biomaterial substates are most often conceived and evaluated by benchtop scientists, but their applications are often limited by the creativity and skill of clinicians. In this Special Issue of Bioengineering, titled Biomaterials for the Repair and Regeneration of Musculoskeletal Tissue, we will highlight impactful tissue-healing products and surgical techniques from both science/industry and clinical viewpoints. Readers will come away with new knowledge of immediate clinical applications or techniques to improve clinical outcomes, especially in difficult cases.

Dr. Christopher Bibbo
Guest Editor

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Keywords

  • musculoskeletal
  • soft tissue
  • bone
  • cartilage
  • nerve
  • regenerative medicine
  • reconstructive surgery

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Published Papers (1 paper)

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Review

37 pages, 5914 KiB  
Review
Integrating Physical and Biochemical Cues for Muscle Engineering: Scaffolds and Graft Durability
by Farbod Yousefi, Lauren Ann Foster, Omar A. Selim and Chunfeng Zhao
Bioengineering 2024, 11(12), 1245; https://doi.org/10.3390/bioengineering11121245 - 9 Dec 2024
Viewed by 1902
Abstract
Muscle stem cells (MuSCs) are essential for skeletal muscle regeneration, influenced by a complex interplay of mechanical, biochemical, and molecular cues. Properties of the extracellular matrix (ECM) such as stiffness and alignment guide stem cell fate through mechanosensitive pathways, where forces like shear [...] Read more.
Muscle stem cells (MuSCs) are essential for skeletal muscle regeneration, influenced by a complex interplay of mechanical, biochemical, and molecular cues. Properties of the extracellular matrix (ECM) such as stiffness and alignment guide stem cell fate through mechanosensitive pathways, where forces like shear stress translate into biochemical signals, affecting cell behavior. Aging introduces senescence which disrupts the MuSC niche, leading to reduced regenerative capacity via epigenetic alterations and metabolic shifts. Transplantation further challenges MuSC viability, often resulting in fibrosis driven by dysregulated fibro-adipogenic progenitors (FAPs). Addressing these issues, scaffold designs integrated with pharmacotherapy emulate ECM environments, providing cues that enhance graft functionality and endurance. These scaffolds facilitate the synergy between mechanotransduction and intracellular signaling, optimizing MuSC proliferation and differentiation. Innovations utilizing human pluripotent stem cell-derived myogenic progenitors and exosome-mediated delivery exploit bioactive properties for targeted repair. Additionally, 3D-printed and electrospun scaffolds with adjustable biomechanical traits tackle scalability in treating volumetric muscle loss. Advanced techniques like single-cell RNA sequencing and high-resolution imaging unravel muscle repair mechanisms, offering precise mapping of cellular interactions. Collectively, this interdisciplinary approach fortifies tissue graft durability and MuSC maintenance, propelling therapeutic strategies for muscle injuries and degenerative diseases. Full article
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