Cardiovascular Models and Biomechanics

Dear Colleagues,

The intricate dance between form and function in the cardiovascular system represents one of the most fascinating areas of bioengineering research. As Guest Editors, we are pleased to announce this Special Issue on "Cardiovascular Models and Biomechanics", aimed at bringing together cutting-edge research that bridges computational modeling, experimental approaches, and clinical applications in cardiovascular biomechanics.

Cardiovascular diseases remain the leading cause of mortality worldwide, placing immense burdens on healthcare systems and patients alike. Engineering approaches offer unique insights into disease mechanisms and potential therapeutic interventions by quantifying the complex biomechanical environments within the cardiovascular system. Recent advances in computational power, imaging technologies, and experimental methods have significantly expanded our ability to model and analyze cardiovascular function across multiple scales—from subcellular processes to organ-level dynamics.

This Special Issue seeks original research articles and review papers that address fundamental and applied aspects of cardiovascular biomechanics. We particularly welcome contributions that integrate computational modeling with experimental validation or clinical applications. Topics of interest include, but are not limited to, the following:

• Multiscale and multiphysics modeling of cardiac and vascular mechanics;
• Patient-specific modeling for surgical planning and intervention design;
• Fluid–structure interaction in cardiovascular flows;
• Biomechanics of cardiovascular devices and implants;
• Mechanobiology of vascular cells and tissues;
• Novel experimental methods for characterizing cardiovascular mechanics;
• Machine learning approaches for cardiovascular modeling and analysis;
• Translational research bridging cardiovascular biomechanics and clinical practice;
• Biomechanical aspects of cardiac development, growth, and remodeling;

We are especially interested in work that demonstrates clear pathways toward clinical translation or that offers new mechanistic insights with potential therapeutic implications. Papers that introduce novel methodological frameworks, validate existing models with experimental data, or establish connections between biomechanical factors and disease progression are highly encouraged.

The complexity of cardiovascular biomechanics necessitates interdisciplinary collaboration. We welcome submissions from diverse fields, including biomedical engineering, mechanical engineering, computational science, cell biology, physiology, and clinical medicine. This Special Issue aims to serve as a platform for cross-disciplinary dialogue that can accelerate innovation in cardiovascular research and healthcare.

Authors are invited to submit their manuscripts through the journal's online submission system, clearly indicating that the submission is intended for the Special Issue "Cardiovascular Models and Biomechanics". All submissions will undergo rigorous peer review according to the journal's established standards. We encourage potential contributors to contact the Guest Editors with questions or to discuss the suitability of proposed topics.

We look forward to receiving your valuable contributions to this exciting field at the intersection of engineering, biomechanics, and cardiovascular medicine. Together, we aim to compile a collection of research that advances our understanding of cardiovascular function and dysfunction, ultimately contributing to improved patient care and outcomes.

Dr. Hwa Liang Leo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• vascular mechanics
• patient-specific modeling
• cardiovascular devices
• mechanobiology
• experimental methods
• computational modeling
• machine learning