Stem Cell Immunoengineering
A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Nanobiotechnology and Biofabrication".
Deadline for manuscript submissions: 31 March 2026
Special Issue Editor
Interests: chimeric antigen receptor engineering immune cells; immunotherapy; pluripotent stem cell engineering; bio-nanotechnology engineering
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Stem cell immunoengineering is transforming the landscape of immunotherapy by combining stem cell biology, genetic engineering, and bioengineering to generate next-generation immune cells with enhanced therapeutic potential. Recent advances include the development of pluripotent stem cell-derived T and NK cells with scalable and standardized manufacturing processes, CRISPR-based multiplex genome editing to improve persistence and reduce exhaustion, and synthetic biology tools enabling programmable immune responses. Additionally, biomaterial-assisted delivery systems and nanotechnology are expanding the toolbox for precise immune modulation and in vivo cell reprogramming.
Despite these advances, key challenges remain, such as improving the efficiency and safety of lineage-specific differentiation, overcoming the immunosuppressive tumor microenvironment, ensuring long-term engraftment and functional persistence, and translating preclinical discoveries into clinically viable therapies. Moreover, addressing regulatory hurdles and developing cost-effective, off-the-shelf universal immune cell products are critical for broadening accessibility.
This collection invites original research and reviews that advance stem cell-based immune engineering, with particular interest in studies that bridge fundamental biological insights with translational and clinical innovation:
- Engineered pluripotent stem cell-derived immune cells.
- Novel genetic and epigenetic programming strategies.
- Biomaterials and delivery platform.
- Single-cell and system immunology approaches.
- Translational and clinical applications.
By fostering interdisciplinary dialogue and highlighting both breakthroughs and challenges, this Special Issue aims to accelerate the development of transformative immunotherapies for cancer, infectious diseases, autoimmunity, and aging-related immune decline.
Dr. Yun Chang
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- stem cell
- immunoengineering
- immune cells
- genetic and epigenetic programming
- biomaterials
- delivery system
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