Nanobiosensors for Age-Related Diseases Diagnosis

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biosignal Processing".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 553

Special Issue Editors


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Guest Editor
Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing 400714, China
Interests: electrochemical biosensors; FET biosensors; fluorescent sensors; nanopore devices for small molecules detection; nanomaterial synthesis
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Guest Editor
Department of Biomedical Engineering, Wake Forest University, Winston-Salem, NC 27109, USA
Interests: biosensors; nanopore sensors; biomarker detection; human biofluids

Special Issue Information

Dear Colleagues,

The process of human aging is complicated, beginning with subclinical and metabolic changes that accrue from midlife onward. Systemic biological changes significantly contribute to many age-related diseases, including neurodegenerative, cardiovascular, metabolic, musculoskeletal, and immune system problems, which are leading causes of premature mortality worldwide. To address the healthcare needs of aging populations, there is an urgent need for the development of innovative platforms for the early detection and treatment of age-related diseases. However, contemporary diagnostic devices encounter challenges stemming from the increasing life expectancy of the global population. These challenges relate not only to the demand for improved performance of diagnostic tests but also to the capacity to create point-of-care, wearable, multiplexing, and implantable diagnostic platforms that enable the early detection, continuous monitoring, and treatment of such diseases. These health challenges present technological issues necessitating resolution through diverse skills. In this context, nanoscience and nanotechnology are crucial for the development of cost-effective, accurate, sensitive, and energy-efficient miniaturized biosensors.

Dr. Chaker Tlili
Dr. Mohamed Amin Elaguech
Guest Editors

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Keywords

  • nanobiosensors
  • nanomaterials
  • age-related diseases
  • wearable devices
  • implantable devices

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Published Papers (1 paper)

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Research

18 pages, 1464 KiB  
Article
A Sandwich-Type Impedimetric Immunosensor for the Detection of Tau-441 Biomarker
by Khouloud Djebbi, Yang Xiang, Biao Shi, Lyes Douadji, Xiaohan Chen, Jin Liu, Chaker Tlili and Deqiang Wang
Bioengineering 2025, 12(8), 805; https://doi.org/10.3390/bioengineering12080805 - 27 Jul 2025
Viewed by 410
Abstract
The human Tau protein stands for one of the most conspicuous and crucial hallmarks of Alzheimer’s disease (AD) diagnosis, along with other tauopathies. However, the assay for direct detection of tiny Tau protein concentrations in human samples continues to pose a significant challenge [...] Read more.
The human Tau protein stands for one of the most conspicuous and crucial hallmarks of Alzheimer’s disease (AD) diagnosis, along with other tauopathies. However, the assay for direct detection of tiny Tau protein concentrations in human samples continues to pose a significant challenge for the early diagnosis of AD. Thus, an amplification-based strategy is required. In this proposed work, we established an impedimetric immunosensor to detect human Tau-441 protein in PBS buffer using a sandwich approach, wherein we employed two distinct monoclonal antibodies (HT7 and BT2) that specifically recognize the amino acids 159–198 of the target protein. Through this strategy, we were able to detect as low as 0.08 pg/mL. These findings were attributed to the use of a biotinylated antibody (BT2)-streptavidin complex, which facilitated the amplification of the normalized signal, resulting in a lower limit of detection in comparison to the directly based immunosensors. Subsequently, we investigated the designed immunosensor to assess the assay’s selectivity in the presence of different off-targets, and no cross-interaction was recorded. The outcomes of our study provide valuable new insights into the application of sandwich-based assay as a highly sensitive and selective immunosensor for the detection of small protein. Full article
(This article belongs to the Special Issue Nanobiosensors for Age-Related Diseases Diagnosis)
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