Bio-Applications of Engineered Escherichia coli—Second Volume

Dear Colleagues,

The model organism Escherichia coli has several interesting properties and molecular tools available that make it preferable for synthetic biology applications. Some of the desired properties include its small genome size, high product yield, fast growth in cheap media, cost-effectiveness and its ease in being scaled up. Therefore, engineered E. coli has been explored in recent decades for the production of a vast number of value-added compounds, such as industrial chemicals and even drugs and food ingredients. Indeed, most heterologous proteins for therapeutic use are industrially produced using this chassis. In addition, engineered E. coli is frequently used as a chassis in the development of whole-cell biosensors for the detection of several analytes, including proteins. These biosensors have been exploited in different areas, from the detection of pollutants to the development of diagnostic tools. Moreover, engineered E. coli is also being explored as a delivery method for therapeutic agents.

This Special Issue on “Bio-Applications of Engineered Escherichia coli—Second Volume” will focus on original research papers, comprehensive reviews and communications on the use of engineered E. coli to solve several of mankind’s problems. We welcome engineered E. coli applications related to the production of value-added compounds that promote sustainable and economically viable industrial processes, the development of new diagnosis tools and treatments, and ways to fight global warming, among other topics.

Areas of interest for this Special Issue include, but are not limited to, the following:

• E. coli as a chassis for the expression of heterologous pathways for value-added compound production;
• E. coli as a chassis for the production of therapeutic proteins and/or molecules;
• Development of improved E.coli strains to overcome limitations (e.g., the absence of post-translational modifications);
• Development of tools to improve E.coli engineering;
• E. coli as a whole-cell biosensor in diagnostic tools, pollution detection, etc.;
• Engineered E. coli as a therapeutic agent.

Dr. Joana Rodrigues
Dr. Debora Ferreira
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• Escherichia coli
• heterologous production
• biosynthetic pathways
• value-added compounds
• microbial chassis
• microbial host
• biosensors
• whole-cell biosensors
• diagnosis tools
• therapeutic tools