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Open AccessArticle

Carpinus turczaninowii Extract May Alleviate High Glucose-Induced Arterial Damage and Inflammation

1
Department of Anatomy, Chonnam National University Medical School, Gwangju 61469, Korea
2
Department of Food Science and Nutrition, Dong-A University, 37 550 beon-gil Nakdongdae-ro, Saha-gu, Busan 49315, Korea
3
Center for Silver-Targeted Biomaterials, Brain Busan 21 Plus Program, Dong-A University, 37 550beon-gil Nakdongdae-ro, Saha-gu, Busan 49315, Korea
4
Institute of Health Insurance and Clinical Research, National Health Insurance Service Ilsan Hospital, 100 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do 10444, Korea
5
Biological Resources Utilization Department, National Institute of Biological Resources, 42 Hwangyeong-ro, Seo-gu Incheon 22689, Korea
6
Department of Food Science & Technology, and Institute of Agriculture and Life Science, Gyeongsang National University, 501 Jinju-daero, Jinju 52828, Korea
*
Author to whom correspondence should be addressed.
These two authors contributed equally to the work as primary authors.
Antioxidants 2019, 8(6), 172; https://doi.org/10.3390/antiox8060172
Received: 6 May 2019 / Revised: 2 June 2019 / Accepted: 7 June 2019 / Published: 11 June 2019
(This article belongs to the Special Issue Antioxidant and Anti-inflammatory Properties of Plants Extract)
Hyperglycemia-induced oxidative stress triggers severe vascular damage and induces an inflammatory vascular state, and is, therefore, one of the main causes of atherosclerosis. Recently, interest in the natural compound Carpinus turczaninowii has increased because of its reported antioxidant and anti-inflammatory properties. We investigated whether a C. turczaninowii extract was capable of attenuating high glucose-induced inflammation and arterial damage using human aortic vascular smooth muscle cells (hASMCs). mRNA expression levels of proinflammatory response [interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)], endoplasmic reticulum (ER) stress [CCAAT-enhancer-binding proteins (C/EBP) homologous protein (CHOP)], and adenosine monophosphate (AMP)-protein activated kinase α2 (AMPK α2)], and DNA damage [phosphorylated H2.AX (p-H2.AX)] were measured in hASMCs treated with the C. turczaninowii extracts (1 and 10 μg/mL) after being stimulated by high glucose (25 mM) or not. The C. turczaninowii extract attenuated the increased mRNA expression of IL-6, TNF-α, and CHOP in hASMCs under high glucose conditions. The expression levels of p-H2.AX and AMPK α2 induced by high glucose were also significantly decreased in response to treatment with the C. turczaninowii extract. In addition, 15 types of phenolic compounds including quercetin, myricitrin, and ellagic acid, which exhibit antioxidant and anti-inflammatory properties, were identified in the C. turczaninowii extract through ultra-performance liquid chromatography-quadrupole-time of flight (UPLC-Q-TOF) mass spectrometry. In conclusion, C. turczaninowii may alleviate high glucose-induced inflammation and arterial damage in hASMCs, and may have potential in the treatment of hyperglycemia-induced atherosclerosis. View Full-Text
Keywords: Carpinus turczaninowii; human aortic vascular smooth muscle cells; high glucose; inflammation; arterial damage; phenolic compounds Carpinus turczaninowii; human aortic vascular smooth muscle cells; high glucose; inflammation; arterial damage; phenolic compounds
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Song, J.; Yoon, S.R.; Son, Y.K.; Bang, W.Y.; Bae, C.-H.; Yeo, J.-H.; Kim, H.-J.; Kim, O.Y. Carpinus turczaninowii Extract May Alleviate High Glucose-Induced Arterial Damage and Inflammation. Antioxidants 2019, 8, 172.

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