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Article

Anti-Inflammatory, Anti-Arthritic and Anti-Nociceptive Activities of Nigella sativa Oil in a Rat Model of Arthritis

1
School of Pharmacy, Pharmacology Unit, University of Camerino, 62032 Camerino, MC, Italy
2
School of Pharmacy, Molecular Biology Unit, University of Camerino, 62032 Camerino, MC, Italy
3
School of Science and Technology, Computer Science Division, University of Camerino, 62032 Camerino, MC, Italy
4
Department of Agricultural, Food and Environmental Sciences, University of Perugia, 06121 Perugia, Italy
*
Author to whom correspondence should be addressed.
Antioxidants 2019, 8(9), 342; https://doi.org/10.3390/antiox8090342
Received: 28 July 2019 / Revised: 16 August 2019 / Accepted: 18 August 2019 / Published: 25 August 2019
(This article belongs to the Special Issue Antioxidant and Anti-inflammatory Properties of Plants Extract)
This study investigated the preventive efficacy of the crude oil extracted from Nigella sativa seeds in a rat model of arthritis induced by using complete Freund’s adjuvant (CFA). Nigella sativa oil at 1.82 mL/kg or 0.91 mL/kg (corresponding to 1596 and 798 mg/kg, respectively) was orally administered for 25 days from the day of immunization. One immunized group was treated orally with indomethacin (3 mg/kg) as a reference drug. Body weight growth rate, paw swelling, arthritis score, mechanical allodynia, locomotor activity and anxiety-like behavior were observed, and the levels of Interleukin 6 (IL-6), C-reactive protein, albumin and total cholesterol in plasma were measured on days 15 and 25. Nigella sativa oil showed anti-inflammatory, anti-arthritic and anti-nociceptive activities that were significant as compared to untreated arthritic rats but less than indomethacin. These results indicated that Nigella sativa oil significantly attenuated adjuvant-arthritis in rats and the higher dose (1.82 mL/kg) prevented the development of arthritis with an inhibition of 56%. View Full-Text
Keywords: Nigella sativa; adjuvant arthritis; inflammation; IL-6; clustering Nigella sativa; adjuvant arthritis; inflammation; IL-6; clustering
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MDPI and ACS Style

Nasuti, C.; Fedeli, D.; Bordoni, L.; Piangerelli, M.; Servili, M.; Selvaggini, R.; Gabbianelli, R. Anti-Inflammatory, Anti-Arthritic and Anti-Nociceptive Activities of Nigella sativa Oil in a Rat Model of Arthritis. Antioxidants 2019, 8, 342. https://doi.org/10.3390/antiox8090342

AMA Style

Nasuti C, Fedeli D, Bordoni L, Piangerelli M, Servili M, Selvaggini R, Gabbianelli R. Anti-Inflammatory, Anti-Arthritic and Anti-Nociceptive Activities of Nigella sativa Oil in a Rat Model of Arthritis. Antioxidants. 2019; 8(9):342. https://doi.org/10.3390/antiox8090342

Chicago/Turabian Style

Nasuti, Cinzia, Donatella Fedeli, Laura Bordoni, Marco Piangerelli, Maurizio Servili, Roberto Selvaggini, and Rosita Gabbianelli. 2019. "Anti-Inflammatory, Anti-Arthritic and Anti-Nociceptive Activities of Nigella sativa Oil in a Rat Model of Arthritis" Antioxidants 8, no. 9: 342. https://doi.org/10.3390/antiox8090342

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