Reactive Oxygen Species as Modulators of Redox-Dependent Signal Transduction Pathways

Dear Colleagues,

Redox systems, which are controlled by the exogenous or endogenous signals that govern the life of cells, tissues, and the entire body, have received the interest of scientists in different disciplines, from basic science to scientific applications. Indeed, while adequate levels of reactive oxygen species (ROS) are essential for sustaining cell proliferation and survival, alterations of redox homeostasis may bring about cell dysfunction and death. Under physiological conditions, therefore, a strict balance between the generation and disposal of ROS ensures the proper functioning of redox-sensitive signalling proteins. Along these lines, understanding the mechanisms underlying cellular redox homeostasis may help us to develop new therapeutical strategies to counteract the development of a wide range of redox-dependent pathologies, including cardiovascular, neurodegenerative, and inflammatory-based diseases and cancer.

The aim of this Special Issue is to bring together recent research, in the form of either original research papers or reviews, on the activity and control of redox-regulated cell systems in physiological processes and pathological conditions. These can include both in vitro and in vivo studies aiming to explore molecular mechanisms as well as cell and body responses. In addition, the role of phytochemicals and xenobiotics in the control of redox-dependent pathophysiological conditions will be considered.

Prof. Dr. Mario Allegra
Guest Editor

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