2025 May - 123 articles
Background: Diabetic macular edema (DME) is the most common cause of vision loss among diabetic patients. The first-line treatments for DME are anti-vascular endothelial growth factor (VEGF)-drugs, while intravitreal steroids are generally reserved f...
Fontan circulation is a fragile system in which imperfections at any of multiple levels may compromise the quality of life, produce secondary pathophysiology, and shorten life span. Increased inferior vena caval pressure itself may play a role in &ld...
Perfusion offers unique benefits to tissue-engineered systems, enhancing oxygen and nutrient transport, which improves tissue formation and growth. In this study, we present a novel and integrated portable perfusion system. Weighing < 10 lbs, the...
We present a mechanistic mathematical model of the basal state for type 2 diabetes mellitus (T2DM) in an analytical form and illustrate its use for in silico basal-state and dynamic studies. At the core of the basal-state model is a quartic equation...
Brain tumours (BTs) are among the most dangerous and life-threatening cancers in humans of all ages, and the early detection of BTs can make a huge difference to their treatment. However, grade recognition is a challenging issue for radiologists invo...
Background: Parkinson’s disease (PD) affects both motor and non-motor functions, but their interactions are understudied. This study aims to explore the relationships between non-motor and motor effects of PD, focusing on depression, fatigue, g...
The fundus manifestations of pseudopapilledema closely resemble those of optic disc edema, making their differentiation particularly challenging in certain clinical situations. However, rapid and accurate diagnosis is crucial for alleviating patient...
Orthodontic mini-implants (MIs) are excellent alternative skeletal anchorage devices. Their stability is important for their survival, requiring appropriate torque application during insertion and removal. Objective: This study aimed to evaluate the...
Age-related macular degeneration (AMD) is a multifactorial retinal disease influenced by complex molecular mechanisms, including genetic susceptibility, inflammation, oxidative stress, and metabolic dysregulation. While substantial progress has been...
In a world characterized by rapid industrialization and a growing population, plastic or polymeric waste handling has undergone significant transformations. Recycling has become a major strategy where silk sericin has great potential among recyclable...
Temporomandibular joint replacement is a critical intervention for severe temporomandibular joint disorders, enhancing pain levels, jaw function and overall quality of life. In this study, we compare two finite element method-based simulation workflo...
Developing fibrochondrogenic serum-free media is important for regenerating diseased and injured fibrocartilage but no defined protocols exist. Towards this goal, we characterized the effect of four candidate fibrochondrogenic serum-free media contai...
Frailty in the elderly population is associated with increased vulnerability to stressors, including surgical interventions. This study compared machine learning (ML) models with a clinical bedside tool, the Gastrointestinal Surgery Frailty Index (Gi...
Zirconia dental implants have emerged as a transformative material in implantology, offering a biocompatible, esthetic, and durable alternative to traditional titanium implants. This comprehensive review explores the key properties of zirconia, inclu...
Since the COVID-19 pandemic, interest in non-contact diagnostic technologies has grown, leading to increased research into remote biosignal monitoring. The respiratory rate, widely used in previous studies, offers limited insight into pulmonary volum...
(1) Background: Ischemic stroke is a major global public-health concern with complex pathogenesis. Current treatment strategies face challenges. Low-intensity pulsed ultrasound stimulation (LIPUS), a non-invasive neuromodulation technology, shows pro...
Veno-arterial extracorporeal membrane oxygenation (VA ECMO) for the management of refractory cardiogenic shock (CS) has been widely used in recent years. Increased left ventricular (LV) afterload induced by retrograde flow remains a limiting factor,...
Meniscoplasty is a common surgical procedure used to treat meniscus tears. During the operation, there are often key challenges such as a limited visual field, a narrow operating space, and difficulties in controlling the resection range. Therefore,...
Accurate preoperative prediction of biochemical recurrence (BCR) in prostate cancer (PCa) is essential for treatment optimization, and demands an explicit focus on tumor microenvironment (TME). To address this, we developed MRMS-CNNFormer, an innovat...
Conventional mild hydrotreatment processes of bio-oil present significant challenges of a high degree of polymerization, a low oil yield, high coke formation, and poor catalyst recovery. To address these challenges, the current study looked into inve...
Sepsis-associated acute kidney injury (SA-AKI) is a life-threatening complication of sepsis, characterized by high mortality and prolonged hospitalization. Early diagnosis and effective therapy remain difficult despite extensive investigation. To add...
Objective: This study aimed to investigate the effects of neuromuscular electrical stimulation (NMES) on lower limb muscle synergies during the single-leg hop test in martial artists after anterior cruciate ligament (ACL) reconstruction. Methods: Twe...
The surface properties of the running surface have an effect on physiological and biomechanical responses to exercise, but their influence on body composition, blood pressure, and knee joint kinetics during controlled sports loading is less researche...
In the dentistry field, dental caries is a common issue affecting all age groups. The presence of dental braces and dental restoration makes the detection of caries more challenging. Traditionally, dentists rely on visual examinations to diagnose car...
So far, synthetic biology approaches for the construction of artificial microorganisms have fostered the transformation of acceptor cells with genomes from donor cells. However, this strategy seems to be limited to closely related bacterial species o...
This systematic review analyzed the combined use of aligners and orthodontic temporary anchorage devices (TADs) in orthodontic treatment. The aim was to evaluate the effectiveness, benefits, and potential challenges of integrating the use of miniscre...
Machine Learning models, more specifically Artificial Neural Networks, are transforming medical imaging by enabling precise liver segmentation, a crucial task for diagnosing and treating liver diseases. However, these models often face challenges in...
Daily exposure to various forces creates defects in the musculoskeletal system, leading to health issues, especially for bones. Bone tissue scaffolds and ultrasound technology are both utilized in research and in clinics to enhance bone tissue regene...
Multimodal physiological emotion recognition is challenged by modality heterogeneity and inter-subject variability, which hinder model generalization and robustness. To address these issues, this paper proposes a new framework, Cross-modal Transforme...
Evaluating bone tunnels is crucial for assessing functional recovery after anterior cruciate ligament reconstruction. Conventional methods are imprecise, time-consuming, and labor-intensive. This study introduces a novel deep learning-based system fo...
Industrial workers often engage in repetitive lifting tasks. This type of continual loading on their arms throughout the workday can lead to muscle or tendon injuries. A non-intrusive system designed to assist a worker’s arms would help allevia...
Osteoarthritis (OA) is a chronic degenerative joint disease characterized by low-grade inflammation, cartilage breakdown, and persistent pain. Despite its prevalence, current therapeutic strategies primarily focus on symptom management rather than mo...
Research on anaerobic digestion (AD) is still booming in the first quarter of the 21st century [...]
Impaired motor function is a defining characteristic of Parkinson’s disease (PD). Galvanic vestibular stimulation (GVS) has been proposed as a potential non-invasive intervention to enhance motor performance; however, its efficacy depends on bo...
Tension-free hernioplasty has effectively reduced postoperative recurrence and mitigated complications by employing polymer patches. However, clinically used polymer patches often fall short in terms of the anti-deformation, anti-adhesion, and tissue...
The rapid growth of wearable technology has opened new possibilities for smart health-monitoring systems. Among various sensing methods, bio-impedance sensing has stood out as a powerful, non-invasive, and energy-efficient way to track physiological...
Myocardial infarction is one of the most severe forms of ischemic heart disease, associated with high mortality and disability worldwide. The accurate and reliable prediction of adverse cardiovascular events is critical for developing effective treat...
Cardiovascular diseases (CVD) are the primary cause of death and disability around the world. Over the past decades, several conventional model systems based on two-dimensional (3D) monolayer cultures or experimental animals have been adopted to diss...
Conducted in challenging environments such as disaster or conflict areas, operational medicine presents unique challenges for the delivery of efficient and quality healthcare. It exposes first responders and medical personnel to many unexpected healt...
Depression and anxiety are common comorbidities of stroke. Research has shown that about 30% of stroke survivors develop depression and about 20% develop anxiety. Stroke survivors with such adverse mental outcomes are often attributed to poorer healt...
Glaucoma is a leading cause of irreversible blindness worldwide; therefore, detection of this disease in its early stage is crucial. However, previous efforts to identify early-stage glaucoma have faced challenges, including insufficient accuracy, se...
Tissue conditioners are temporary lining materials applied to dentures to soothe and cushion inflamed or traumatized oral tissues, typically resulting from ill-fitting dentures. This laboratory study aimed to evaluate the physicomechanical properties...
COVID-19 was one of the most serious global public health emergencies in recent years, and its extremely fast spreading speed had a profound negative impact on society. A comprehensive analysis and prediction of COVID-19 could lay a theoretical found...
Artificial intelligence (AI) is revolutionizing the field of orthopedic bioengineering by increasing diagnostic accuracy and surgical precision and improving patient outcomes. This review highlights using AI for orthopedics in preoperative planning,...
Atrial leadless pacemakers (ALPMs) offer a minimally invasive solution for patients requiring atrial pacing, but current designs face significant challenges related to fixation stability, perforation risk, and retrievability. This study presents a no...
Background: Heart failure (HF) ranks among the foremost causes of mortality globally, exhibiting particularly high prevalence and significant impact within intensive care units (ICUs). This study sought to develop, validate, and deploy a time-depende...
This study introduces a novel recombinant humanised collagen (DuCol) developed through codon optimisation and prokaryotic soluble expression, exhibiting exceptional biocompatibility and bioactivity. Structural integrity was confirmed via RP-HPLC, SEM...
Graphene and its related nanocomposites have garnered significant interest due to their distinct physiochemical and biological properties. In this study, reduced graphene oxide–silver hybrid nanostructures were synthesized for applications in b...
Scoliosis is a three-dimensional deformity of the spine that can lead to a series of physical and psychological problems. Appropriate controlling forces should be applied to prevent the curve’s progression and even correct the deformity. The ai...
Objective: Intraoral scanners (IOS) provide high-precision 3D data of teeth and gingiva, critical for personalized orthodontic diagnosis and treatment planning. However, traditional segmentation methods exhibit reduced performance with complex dental...
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