2025 April - 109 articles
Background: Accurate estimation of myocardial material parameters is crucial to understand cardiac biomechanics and plays a key role in advancing computational modeling and clinical applications. Traditional inverse finite element (FE) methods rely o...
Soil-transmitted helminths (STHs) are parasitic worms that impact over 1.5 billion people globally. The Kato–Katz technique analyzes stool samples for STHs, allowing for individual diagnoses of STH infection and the estimation of community-leve...
Purpose: To compare the efficiency of different manufacturers’ valved cannulas (23G, 25G and 27G) (Alcon, Bausch & Lomb, BVI, DORC, Optikon) in maintaining intraocular pressure during vitrectomy by measuring leak pressure and the difference...
Doxorubicin (DOX) is one of the most powerful chemotherapy drugs used to treat different kinds of cancer. However, its usage has been limited by typical side effects and drug resistance, particularly cardiotoxicity. According to studies, a more effec...
Understanding the diffusion mechanisms of nanocarriers in tumor tissues is crucial for enhancing drug delivery to target areas. This study developed a simulation method combining lattice gas automata and the lattice Boltzmann method to explore the di...
Chronic wound healing is a significant challenge in diabetes. Puerarin is an active compound extracted from the traditional Chinese medicine Pueraria lobata. Puerarin has been used in the treatment of diabetes and derives benefits from its antioxidan...
Burns are common injuries, but their treatment remains challenging due to the complex nature of the wound healing process. Burn wounds are classified into different categories based on their size and depth. Treatment modalities vary significantly acr...
Recent clinical trials have suggested that solid cancers with mismatch repair (MMR) deficiency are highly responsive to immunotherapy, regardless of cancer types. Previous MMR-related studies on breast cancer have predominantly focused on germline va...
Lysosomal enzymes are synthesized as N-glycosylated glycoproteins with mannose-6-phosphate (M6P) moieties, which are responsible for their binding to M6P receptors and transporting to the lysosome. In the M6P biosynthetic pathway, a Man8GlcNAc2 glyco...
(1) Background: Marker-based optical motion tracking is the gold standard in gait analysis; however, markerless solutions are rapidly emerging today. Algorithms like Openpose can track human movement from a video. Few studies have assessed the validi...
This study presents a novel approach for predicting the location and fatigue life of degenerative intervertebral discs (IVDs) under cyclic loading conditions, aiming to improve the understanding of disc degeneration mechanisms. Based on mechanical th...
Peripheral nerve injuries are a significant concern in surgical procedures, often leading to chronic pain and functional impairment. Despite advancements in imaging, preoperative and intraoperative visualization of peripheral nerves remains a challen...
Early diagnosis of skin cancer can significantly improve patient survival. Currently, skin lesion classification faces challenges such as lesion–background semantic entanglement, high intra-class variability, artifactual interference, and more,...
Background: Programmed cell death (PCD) dynamically influences breast cancer (BC) prognosis through interactions with the tumor microenvironment (TME). We investigated 13 PCD patterns to decipher their prognostic impact and mechanistic links to TME-d...
Currently, controversy persists over whether dental implant restoration exacerbates or alleviates temporomandibular disorders (TMDs). This study aimed to analyze the impact of dental implant restoration on the biomechanics of the temporomandibular jo...
Objective: Accurate risk stratification at an early stage may reduce the incidence of infection and improve the survival rate of recipients by adopting targeted interventions. This study aimed to develop a nomogram to predict the risk of multidrug-re...
(1) Background: Flexible flatfoot is characterized by medial arch collapse, leading to musculoskeletal impairments. We examined the effects of single-arch foot orthosis (SFO) and dual-arch foot orthosis (DFO) on arch height, kinematics, and kinetics...
The patient-specific treatment of bone fractures using porous osteoconductive scaffolds has faced significant clinical challenges due to insufficient mechanical strength and bioactivity. These properties are essential for osteogenesis, bone bridging,...
Primary angle-closure glaucoma (PACG), characterized by angle closure (AC) with insidious and irreversible progression, requires precise assessment of AC mechanisms for accurate diagnosis and treatment. This study developed an artificial intelligence...
Objectives: This study’s purpose is to investigate the lumbar biomechanical effects of unilateral partial facetectomy (UPF) of different facet joint (FJ) portions under percutaneous endoscopy. Methods: Forty fresh calf spine models were used to...
Background: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by continuous inflammation of the colon and rectum. Accurate disease assessment is essential for effective treatment, with endoscopic evaluation, particularly t...
Background: Myopia is a leading cause of visual impairment worldwide, and accumulating evidence suggests that biomechanics may be closely linked to its development. Understanding this relationship may help clarify the underlying mechanisms of myopia...
Breast cancer is the most commonly diagnosed cancer worldwide, underscoring the critical need for effective early detection methods to reduce mortality. Traditional detection techniques, such as mammography, present significant limitations, particula...
Transcutaneous spinal cord stimulation (tSCS) is a promising non-invasive method to improve motor function in individuals with spinal cord injury (SCI) by enhancing spinal reflex pathways. This study aimed to investigate the effects of different tSCS...
This study aims to enhance membrane protein production in HEK293T cells through genetic modification. HEK293T cells are used for recombinant protein and viral vector production due to their human origin and post-translational modification capabilitie...
Background: Pulmonary hypertension (PH) is a condition characterized by increased pressure in the pulmonary arteries with poor prognosis and, therefore, an optimal management is necessary. The study’s aim was to search for PH phenotypes and dev...
Cranio-maxillofacial bone defect repair poses significant challenges in oral and maxillofacial surgery due to the complex anatomy of the region and its substantial impact on patients’ physiological function, aesthetic appearance, and quality of...
Medical image registration is essential in clinical practices such as surgical navigation and image-guided diagnosis. The Transformer architecture of TransMorph demonstrates better accuracy in non-rigid registration tasks. However, its weaker spatial...
Over the years, it has been confirmed that bioactive compounds play a pivotal role in human health, particularly in the prevention of chronic diseases [...]
Texture features can capture microstructural patterns and tissue heterogeneity, playing a pivotal role in medical image analysis. Compared to deep learning-based features, texture features offer superior interpretability in clinical applications. How...
The dental profession has a high prevalence of musculoskeletal disorders because daily working life is characterized by many monotonous and one-sided physical exertions. Inertial measurement unit (IMU)-based motion capture (MoCap) is increasingly uti...
Thoracic electrical impedance tomography (EIT) provides real-time, bedside imaging of pulmonary function and has demonstrated significant clinical value in guiding treatment strategies for critically ill patients. However, the practical application o...
The lymphatic system collects excess fluid and molecules from the interstitial space back into the venous system mainly via the thoracic duct (TD). Despite the importance of the lymphatic flow in health and disease, a validated pressure–flow re...
Objective: To explore the synergistic effect of HA380 hemoperfusion adsorbent combined with continuous veno-venous hemodiafiltration (CVVHDF) in the treatment of septic shock. Patients and methods: This retrospective study included 56 adult septic sh...
Sleep apnea, characterized by its high prevalence and serious health consequences, faces a critical bottleneck in diagnosis. Polysomnography (PSG), the gold standard, is costly and cumbersome, while wearable devices struggle with quality control and...
This review evaluates the current evidence on the use of the Neck Imaging Reporting and Data System (NI-RADS) for the surveillance and early detection of recurrent head and neck cancers. NI-RADS offers a standardized, structured framework specificall...
Mitral valve regurgitation is among the most prevalent valvular heart diseases and increases with age. Percutaneous therapy has emerged for the management of mitral regurgitation in high surgical risk patients. However, the long-term consequences of...
Biological hydroxyapatite (BHA) has been extensively employed in alveolar socket preservation, yet its clinical application is often compromised by delayed bone healing triggered by macrophage-mediated pro-inflammatory responses. Building upon our pr...
Balance assessment is crucial for health monitoring and rehabilitation evaluation of neurological diseases like Parkinson’s disease (PD) and stroke. The Berg Balance Scale (BBS) is a widely used clinical tool for balance evaluation. However, it...
Background: The superficial circumflex iliac artery perforator (SCIP) flap is widely recognized for its reliability and minimal donor site morbidity in reconstructive surgery. However, its safety and efficacy in elderly patients—a growing demog...
The ubiquitous presence of per- and polyfluoroalkyl substances (PFAS) in the environment has garnered global public concern. Epidemiological studies have proved that exposure to PFAS is associated with human health risks. Although evidence demonstrat...
The electrocardiogram (ECG) has long been considered the non-invasive gold standard in diagnosing heart diseases. However, its connection with the cardiac molecular biology remains somewhat unclear. Therefore, modeling the electrophysiological behavi...
Background: Primary and secondary salivary gland malignancies differ significantly in treatment and prognosis. However, conventional ultrasonography often struggles to differentiate between these malignancies due to overlapping imaging features. We a...
Rheumatoid arthritis (RA) is a chronic autoimmune disease that can cause severe joint damage and functional impairment. Ultrasound imaging has shown promise in providing real-time assessment of synovium inflammation associated with the early stages o...
Although the existence of highly prevalent pain, disability, and work time lost associated with discogenic low back pain is well known, the recognition of the culpability of universally present disc degradation and mechanical insufficiency in the fir...
Alzheimer’s disease, an irreversible neurodegenerative disorder, manifests through the progressive deterioration of memory and cognitive functions. While magnetic resonance imaging has become an indispensable neuroimaging modality for Alzheimer...
Existing studies have shown that the attentional function of epilepsy is prone to be impaired. However, the characterization of brain connectivity behind this impairment remains uncertain. This study investigates attention-related brain connectivity...
Enhanced external counterpulsation (EECP) treatment has been demonstrated to be effectively vasculoprotective and anti-atherosclerotic in clinical observations and controlled trials. The diastolic blood flow augmentation induced by EECP greatly affec...
Osteoporosis is a metabolic bone disorder characterized by the progressive loss of bone mass, which significantly increases the risk of fractures. While dual-energy X-ray absorptiometry is the standard technique for assessing bone mineral density, it...
The interspinous process device (IPD) has emerged as a viable alternative for managing lumbar degenerative pathologies. Nevertheless, limited research exists regarding mechanical failure modes including device failure and spinous process fracture. Th...
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