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Toxics, Volume 9, Issue 6

2021 June - 30 articles

Cover Story: We have recently demonstrated that ozone, a prototypic air pollutant, mediates pulmonary and systemic effects through the activation of adrenergic receptors (ARs) and glucocorticoid receptors (GRs). A single exposure to ozone induces the sympathetic–adrenal–medullary and hypothalamic–pituitary–adrenal axes, resulting in the release of epinephrine and corticosterone into circulation. These hormones act as ligands for ARs and GRs. The roles of beta AR (βARs) and GRs in ozone-induced pulmonary injury and inflammation were confirmed in a number of studies using interventional approaches. Accordingly, the activation status of ARs and GRs is critical in mediating the health effects of inhaled irritants. In this paper, we review the cellular distribution and functions of ARs and GRs, their lung-specific localization, and their involvement in ozone-induced health effects. View this paper
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Articles (30)

  • Article
  • Open Access
13 Citations
3,696 Views
11 Pages

19 June 2021

Multi-walled carbon nanotubes are engineered nanomaterials (ENMs) that have a fiber-like structure which may be a concern for the development of cellular senescence. Premature senescence, a state of irreversible cell cycle arrest, is implicated in th...

  • Review
  • Open Access
37 Citations
8,630 Views
17 Pages

17 June 2021

Nowadays, arsenic (III) contamination of drinking water is a global issue. Laboratory and instrument-based techniques are typically used to detect arsenic in water, with an accuracy of 1 ppb. However, such detection methods require a laboratory-based...

  • Review
  • Open Access
77 Citations
8,205 Views
26 Pages

Mechanisms of Metal-Induced Mitochondrial Dysfunction in Neurological Disorders

  • Hong Cheng,
  • Bobo Yang,
  • Tao Ke,
  • Shaojun Li,
  • Xiaobo Yang,
  • Michael Aschner and
  • Pan Chen

17 June 2021

Metals are actively involved in multiple catalytic physiological activities. However, metal overload may result in neurotoxicity as it increases formation of reactive oxygen species (ROS) and elevates oxidative stress in the nervous system. Mitochond...

  • Article
  • Open Access
3 Citations
3,569 Views
15 Pages

15 June 2021

Museums air quality can be negatively affected by treatments with heavy metals compounds employed to prevent pest infestations. Among these, the past use of mercury dichloride (HgCl2) on herbaria artifacts currently produces high levels of indoor atm...

  • Article
  • Open Access
21 Citations
4,310 Views
13 Pages

12 June 2021

Microplastics are ubiquitous in aquatic environments and interact with other kinds of pollutants, which affects the migration, transformation, and fate of those other pollutants. In this study, we employ carbamazepine (CBZ) as the contaminant to stud...

  • Review
  • Open Access
35 Citations
4,833 Views
18 Pages

Estimation of the Inhaled Dose of Pollutants in Different Micro-Environments: A Systematic Review of the Literature

  • Francesca Borghi,
  • Andrea Spinazzè,
  • Simone Mandaglio,
  • Giacomo Fanti,
  • Davide Campagnolo,
  • Sabrina Rovelli,
  • Marta Keller,
  • Andrea Cattaneo and
  • Domenico Maria Cavallo

12 June 2021

Recently, the need to assess personal exposure in different micro-environments has been highlighted. Further, estimating the inhaled dose of pollutants is considerably one of the most interesting parameters to be explored to complete the fundamental...

  • Article
  • Open Access
4 Citations
3,053 Views
11 Pages

11 June 2021

Arsenic (As) exists as highly toxic chemical species. Chronic exposure to its inorganic form can cause multiple organ failure and skin cancer in humans, warranting the need to determine the toxicity of each chemical species. This study evaluated the...

  • Article
  • Open Access
20 Citations
4,572 Views
18 Pages

Acute and Cumulative Effects of Repeated Exposure to Chlorpyrifos on the Liver and Kidney Function among Egyptian Adolescents

  • Ahmed A. Ismail,
  • Olfat Hendy,
  • Gaafar Abdel Rasoul,
  • James R. Olson,
  • Matthew R. Bonner and
  • Diane S. Rohlman

10 June 2021

Background: There is a paucity of research that tracks changes in liver and kidney function among pesticide applicators. The aim of the current study was to investigate the role of repeated seasonal exposure to the organophosphorus pesticide, chlorpy...

  • Feature Paper
  • Article
  • Open Access
34 Citations
8,801 Views
20 Pages

A Quantitative 1H NMR Method for Screening Cannabinoids in CBD Oils

  • Ines Barthlott,
  • Andreas Scharinger,
  • Patricia Golombek,
  • Thomas Kuballa and
  • Dirk W. Lachenmeier

10 June 2021

Toxicologically relevant levels of the psychoactive ∆9-tetrahydocannabinol (∆9-THC) as well as high levels of non-psychoactive cannabinoids potentially occur in CBD (cannabidiol) oils. For consumer protection in the fast-growing CBD oil market, facil...

  • Feature Paper
  • Article
  • Open Access
12 Citations
5,845 Views
18 Pages

Food Contaminants Effects on an In Vitro Model of Human Intestinal Epithelium

  • Marion Guibourdenche,
  • Johanna Haug,
  • Noëllie Chevalier,
  • Madeleine Spatz,
  • Nicolas Barbezier,
  • Jérôme Gay-Quéheillard and
  • Pauline M. Anton

9 June 2021

Pesticide residues represent an important category of food contaminants. Furthermore, during food processing, some advanced glycation end-products resulting from the Maillard reaction can be formed. They may have adverse health effects, in particular...

  • Feature Paper
  • Article
  • Open Access
17 Citations
9,153 Views
14 Pages

Nutritional Evaluation and Risk Assessment of the Exposure to Essential and Toxic Elements in Dogs and Cats through the Consumption of Pelleted Dry Food: How Important Is the Quality of the Feed?

  • Ana Macías-Montes,
  • Manuel Zumbado,
  • Octavio P. Luzardo,
  • Ángel Rodríguez-Hernández,
  • Andrea Acosta-Dacal,
  • Cristian Rial-Berriel,
  • Luis D. Boada and
  • Luis Alberto Henríquez-Hernández

5 June 2021

Dry feed for pets lacks specific legislation regarding maximum residue limits for inorganic elements. The aim of the present study was to determine the content of 43 inorganic elements in dog and cat feed, studying whether there were differences acco...

  • Article
  • Open Access
19 Citations
5,150 Views
16 Pages

Effects of Phthalate Esters (PAEs) on Cell Viability and Nrf2 of HepG2 and 3D-QSAR Studies

  • Huan Liu,
  • Huiying Huang,
  • Xueman Xiao,
  • Zilin Zhao and
  • Chunhong Liu

5 June 2021

Phthalate esters (PAEs) are a widespread environmental pollutant, and their ecological and environmental health risks have gradually attracted attention. To reveal the toxicity characteristics of these compounds, ten PAEs were selected as research ob...

  • Article
  • Open Access
8 Citations
3,293 Views
14 Pages

Daytime Restricted Feeding Modifies the Temporal Expression of CYP1A1 and Attenuated Damage Induced by Benzo[a]pyrene in Rat Liver When Administered before CYP1A1 Acrophase

  • Oscar Samuel Ávila-Rosales,
  • Mauricio Díaz-Muñoz,
  • Rafael Camacho-Carranza,
  • Elvia Coballase-Urrutia,
  • José Pedraza-Chaverri,
  • Jorge Omar García-Rebollar and
  • Jesús Javier Espinosa-Aguirre

4 June 2021

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that heterodimerizes with the AhR nuclear translocator (ARNT) to modulate CYP1A1 expression, a gene involved in the biotransformation of benzo[a]pyrene (BaP). The AhR path...

  • Review
  • Open Access
307 Citations
23,323 Views
19 Pages

Nanopesticides in Agriculture: Benefits and Challenge in Agricultural Productivity, Toxicological Risks to Human Health and Environment

  • Marco Chaud,
  • Eliana B. Souto,
  • Aleksandra Zielinska,
  • Patricia Severino,
  • Fernando Batain,
  • Jose Oliveira-Junior and
  • Thais Alves

4 June 2021

Nanopesticides are nanostructures with two to three dimensions between 1 to 200 nm, used to carry agrochemical ingredients (AcI). Because of their unique properties, the loading of AcI into nanoparticles offers benefits when compared to free pesticid...

  • Review
  • Open Access
12 Citations
11,177 Views
27 Pages

Adrenergic and Glucocorticoid Receptors in the Pulmonary Health Effects of Air Pollution

  • Myles X. Hodge,
  • Andres R. Henriquez and
  • Urmila P. Kodavanti

4 June 2021

Adrenergic receptors (ARs) and glucocorticoid receptors (GRs) are activated by circulating catecholamines and glucocorticoids, respectively. These receptors regulate the homeostasis of physiological processes with specificity via multiple receptor su...

  • Article
  • Open Access
5 Citations
5,219 Views
18 Pages

Role of Macrophages in Cytotoxicity, Reactive Oxygen Species Production and DNA Damage in 1,2-Dichloropropane-Exposed Human Cholangiocytes In Vitro

  • Abigail Ekuban,
  • Cai Zong,
  • Frederick Adams Ekuban,
  • Yusuke Kimura,
  • Ryoya Takizawa,
  • Kota Morikawa,
  • Kazuo Kinoshita,
  • Sahoko Ichihara,
  • Seiichiroh Ohsako and
  • Gaku Ichihara

1 June 2021

1,2-Dichloropropane (1,2-DCP), a synthetic chlorinated organic compound, was extensively used in the past in offset color proof-printing. In 2014, the International Agency for Research on Cancer (IARC) reclassified 1,2-DCP from its initial Group 3 to...

  • Article
  • Open Access
83 Citations
9,732 Views
13 Pages

Distribution and Seasonal Variation of Microplastics in Tallo River, Makassar, Eastern Indonesia

  • Ega Adhi Wicaksono,
  • Shinta Werorilangi,
  • Tamara S. Galloway and
  • Akbar Tahir

1 June 2021

Attention towards microplastic (MP) pollution in various environments is increasing, but relatively little attention has been given to the freshwater-riverine environment. As the biggest city in the eastern Indonesia region, Makassar can be a potenti...

  • Article
  • Open Access
24 Citations
4,767 Views
17 Pages

RETRACTED: Biosynthesized Iron Oxide Nanoparticles from Petroselinum crispum Leaf Extract Mitigate Lead-Acetate-Induced Anemia in Male Albino Rats: Hematological, Biochemical and Histopathological Features

  • Sabry M. El-Bahr,
  • Amal M. Elbakery,
  • Nashwa El-Gazzar,
  • Aziza A. Amin,
  • Saad Al-Sultan,
  • Mohammed A. Alfattah,
  • Saad Shousha,
  • Sameer Alhojaily,
  • Mohammad Shathele and
  • Ahlam F. Hamouda
  • + 1 author

31 May 2021

This study aimed to investigate the ameliorative effects of iron oxide nanoparticles (IONPs) prepared from leaf extract of Petroselinum crispum compared to those prepared using a chemical method in lead-acetate-induced anemic rats. Twenty rats were d...

  • Article
  • Open Access
5 Citations
3,791 Views
12 Pages

Tissue-Specific Distribution of Legacy and Emerging Organophosphorus Flame Retardants and Plasticizers in Frogs

  • Yin-E Liu,
  • Xiao-Jun Luo,
  • Ke-Lan Guan,
  • Chen-Chen Huang,
  • Xue-Meng Qi,
  • Yan-Hong Zeng and
  • Bi-Xian Mai

31 May 2021

Five types of tissues, including the liver, kidney, intestine, lung, and heart, were collected from black-spotted frogs and bullfrogs to study the tissue-specific accumulation of organophosphorus flame retardants (PFRs) and plasticizers. Thirteen PFR...

  • Feature Paper
  • Article
  • Open Access
37 Citations
6,263 Views
31 Pages

Which Is More Toxic? Evaluation of the Short-Term Toxic Effects of Chlorpyrifos and Cypermethrin on Selected Biomarkers in Common Carp (Cyprinus carpio, Linnaeus 1758)

  • Elenka Georgieva,
  • Vesela Yancheva,
  • Stela Stoyanova,
  • Iliana Velcheva,
  • Ilia Iliev,
  • Tonka Vasileva,
  • Veselin Bivolarski,
  • Eleonora Petkova,
  • Brigitta László and
  • László Antal
  • + 1 author

31 May 2021

The general aim of this study was to investigate the negative short-term effects of different concentrations of chlorpyrifos (CPF) and cypermethrin (CYP), based on the EU legislation (MAC-EQS) in common carp (Cyprinus carpio Linnaeus, 1758) under lab...

  • Article
  • Open Access
6 Citations
3,690 Views
13 Pages

31 May 2021

Glyphosate is the most used herbicide worldwide, but enormous use of glyphosate has raised concerned about its environmental loadings. Although glyphosate is considered non-toxic, toxicity data for soil non-target organisms according to temperature a...

  • Feature Paper
  • Article
  • Open Access
5 Citations
5,336 Views
13 Pages

Large-Scale Spraying of Roads with Water Contributes to, Rather Than Prevents, Air Pollution

  • Fengzhu Tan,
  • Yuming Guo,
  • Wei Zhang,
  • Xingyan Xu,
  • Ming Zhang,
  • Fan Meng,
  • Sicen Liu,
  • Shanshan Li and
  • Lidia Morawska

28 May 2021

Spraying roads with water on a large scale in Chinese cities is one of the supplementary precaution or mitigation actions implemented to control severe air pollution events or heavy haze-fog events in which the mechanisms causing them are not yet ful...

  • Feature Paper
  • Article
  • Open Access
9 Citations
4,763 Views
14 Pages

Ocean Warming May Enhance Biochemical Alterations Induced by an Invasive Seaweed Exudate in the Mussel Mytilus galloprovincialis

  • Hugo C. Vieira,
  • Andreia C. M. Rodrigues,
  • Sílvia F. S. Pires,
  • Jacinta M. M. Oliveira,
  • Rui J. M. Rocha,
  • Amadeu M. V. M. Soares and
  • Maria D. Bordalo

28 May 2021

Ocean warming and biological invasions are among the most pervasive factors threatening coastal ecosystems with a potential to interact. Ongoing temperature rise may affect physiological and cellular mechanisms in marine organisms. Moreover, non-indi...

  • Article
  • Open Access
4 Citations
4,188 Views
9 Pages

Factors Predicting Acute Brain Injury in Cases of Carbon Monoxide Poisoning: A Prospective Registry-Based Study

  • Hoon Lim,
  • Young Hwan Lee,
  • Sangun Nah,
  • Sungwoo Choi,
  • Young Soon Cho,
  • Gi Woon Kim,
  • Ji Eun Moon and
  • Sangsoo Han

27 May 2021

Carbon monoxide (CO) is one of the most common poisoning substances worldwide. Since acute brain injury (ABI) is an important determinant of the neurological outcome in CO poisoning, screening for patients at a high risk of developing ABI is essentia...

  • Feature Paper
  • Article
  • Open Access
27 Citations
5,503 Views
14 Pages

25 May 2021

This study examines the effects of acute pharmacological modulation of the serotonergic system over zebrafish larvae’s cognitive, basic, and defense locomotor behaviors, using a medium to high throughput screening assay. Furthermore, the relationship...

  • Article
  • Open Access
10 Citations
4,406 Views
22 Pages

Toxicological Evaluation of Novel Cyclohexenone Derivative in an Animal Model through Histopathological and Biochemical Techniques

  • Muhammad Kamil,
  • Arifa Fatima,
  • Sami Ullah,
  • Gowhar Ali,
  • Rasool Khan,
  • Naila Ismail,
  • Mughal Qayum,
  • Marius Irimie,
  • Catalina Georgeta Dinu and
  • Maria Elena Cocuz
  • + 1 author

25 May 2021

Toxicity studies were conducted to provide safety data of potential drug candidates by determining lethal and toxic doses. This study was designed for pre-clinical evaluation of novel cyclohexenone derivative with respect to the acute and sub-acute t...

  • Article
  • Open Access
4 Citations
3,347 Views
13 Pages

Effects of Acrylamide-Induced Vasorelaxation and Neuromuscular Blockage: A Rodent Study

  • Wei-De Lin,
  • Chu-Chyn Ou,
  • Shih-Hao Hsiao,
  • Chih-Han Chang,
  • Fuu-Jen Tsai,
  • Jiunn-Wang Liao and
  • Yng-Tay Chen

24 May 2021

Acrylamide (ACR), which is formed during the Maillard reaction, is used in various industrial processes. ACR accumulation in humans and laboratory animals results in genotoxicity, carcinogenicity, neurotoxicity, and reproductive toxicity. In this stu...

  • Feature Paper
  • Article
  • Open Access
17 Citations
4,519 Views
15 Pages

Evaluation of the Potential of Sewage Sludge Mycobiome to Degrade High Diclofenac and Bisphenol-A Concentrations

  • Ulises Conejo-Saucedo,
  • Alejandro Ledezma-Villanueva,
  • Gabriela Ángeles de Paz,
  • Mario Herrero-Cervera,
  • Concepción Calvo and
  • Elisabet Aranda

23 May 2021

One of the most challenging environmental threats of the last two decades is the effects of emerging pollutants (EPs) such as pharmaceutical compounds or industrial additives. Diclofenac and bisphenol A have regularly been found in wastewater treatme...

  • Feature Paper
  • Article
  • Open Access
9 Citations
3,986 Views
11 Pages

Differential Modulation of the Central and Peripheral Monoaminergic Neurochemicals by Deprenyl in Zebrafish Larvae

  • Marina Bellot,
  • Helena Bartolomé,
  • Melissa Faria,
  • Cristian Gómez-Canela and
  • Demetrio Raldúa

23 May 2021

Zebrafish embryos and larvae are vertebrate models increasingly used in translational neuroscience research. Behavioral impairment induced by the exposure to neuroactive or neurotoxic compounds is commonly linked to changes in modulatory neurotransmi...

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Toxics - ISSN 2305-6304