Special Issue "Effects of Exposure to Air Pollution on Respiratory Health"

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Toxicology and Public Health".

Deadline for manuscript submissions: 20 October 2020.

Special Issue Editor

Dr. Swapna Upadhyay
Guest Editor
IMM: Institute of Environmental Medicine, Unit of Integrative Toxicology, Karolinska Institutet, SE-171 77 Stockholm, Sweden
Interests: acute and chronic lung disease (COPD); outdoor (particles and gaseous agents) and indoor (biomass smoke) air pollutants; occupational chemical exposure; E-cigarette exposure; AOP for respiratory disease: Advanced in vitro lung mucosa model to human translational approaches

Special Issue Information

Dear colleagues,

The air we breathe has important consequences on our health and development. The respiratory system is a primary target of air pollution-mediated health effects. Ambient air pollution is an established cause of morbidity and mortality—like tobacco smoke. Even more than passive smoking, air pollution is not a lifestyle choice, but ubiquitous involuntary environmental exposure, which can affect the entire population, from womb to death. The enormous burden of disease due to air pollution is increasingly being considered by governments and institutions around the globe as a major public health concern. Respirable particulate matter (PM) has been regarded as a “criteria air pollutant”, along with carbon monoxide, ground level ozone, fine- and ultra-fine particulate matters, diesel/biodiesel particles, metal particles (lead, palladium, etc.), nitrogen dioxide, and sulphur dioxide. Globally, >8 million premature deaths are related to outdoor and indoor air-pollution. Low- and lower-middle income countries (LMICs) bear the maximum brunt of air pollution-related adverse health effects. The source of air pollution in LMICs is two pronged—outdoor and indoor air pollution. Rapid urbanization and industrialization, on the one hand (urban), with a lack of clean energy sources, leading to the use of biomass fuel for cooking and heating purposes (rural), happens simultaneously. A substantial body of epidemiological evidence indicates the association of chronic respiratory diseases like asthma and chronic obstructive pulmonary disease (COPD) to ambient PM exposure. It is estimated that approximately 50% of COPD cases, the fourth leading cause of death globally, can be attributed to non-tobacco-related causes. It is plausible that the mechanism of air pollution-related COPD may be different from tobacco-smoke-mediated COPD. Thus, environmental and occupational causes COPD warrant more attention. Although several works of epidemiological evidence showing the association between exposure to air pollutants and various respiratory impairments do exist. However, details of the molecular mechanism leading to the onset of chronic respiratory (e.g., COPD) diseases remain unclear or under explored.

Therefore, in this Special Issue of Toxics will cover the most recent research on air pollution related respiratory diseases, namely:

  • Respiratory toxicity following exposure to air pollutants.
  • Outdoor and indoor air quality monitoring: special focus on LMIC.
  • Gender perspective air pollution (indoor and outdoor) mediated respiratory adverse outcome pathways.
  • Acute and repeated exposure to ambient gaseous and particulate matters using advanced/physiologically-relevant in vitro models.
  • Air pollutant and molecular pathogenesis for COPD onset: in vivo to human study.

Dr. Swapna Upadhyay
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • air pollutants
  • respiratory diseases
  • indoor and outdoor air pollution
  • respiratory diseases and AOP
  • air pollution and COPD

Published Papers

This special issue is now open for submission.
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