Phthalate Exposure: From Quantification to Risk Assessment

Dear Colleagues,

Phthalates, the diesters of phthalic acid, are industrial chemicals widely used in commercial products. The ubiquitous use of phthalates results in human exposure from food, dermal absorption, inhalation, and parenteral use of medical—in addition to possible occupational—exposure.

Phthalates have been evaluated as possible human toxicants, and their toxicity has been extensively reviewed. Mainly phthalates possess endocrine-disrupting properties, with evidence for involvement in reproductive toxicity (both for men and women); they seem to be involved in metabolic disease, and there is interest in the scientific literature in a possible role played by phthalates in the onset of other illnesses linked to female hormones (e.g., endometriosis).

The environmental and biological monitoring of phthalates is a starting point to understand the real level of exposure for humans—first of all, distinguished between the base level in the environment and other sources of exposure (e.g., occupational). An important target is the proposal of analytical methods able to quantify low concentrations in different complex matrixes, particularly in human biomonitoring.

Any contribution to the clarification of the mechanisms of action of these chemical compounds in the human body and to the understanding of the role they play in producing adverse effects on health is necessary for the scientific community to orient itself and propose risk-prevention measures.

Dr. Lidia Caporossi
Professor Maria Marino
Guest Editor

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