Special Issue "Toxic Neuropathy: Mechanisms, Causes, Risk Exposure, Diagnosis, Prevention and Therapeutic Options"

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Toxicology".

Deadline for manuscript submissions: 30 June 2021.

Special Issue Editors

Dr. Valentina Carozzi
E-Mail Website
Guest Editor
Unità di Neurologia Sperimentale e Centro di Neuroscienze di Milano, Dipartimento di Chirurgia e Medicina traslazionale, Università di Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy
Interests: peripheral neuropathies, antineoplastic drugs, animal models
Special Issues and Collections in MDPI journals
Prof. Dr. Wolfgang Grisold
E-Mail
Guest Editor
Ludwig Boltzmann Institute for Experimental und Clinical Traumatology, Vienna, Austria
Interests: neurotoxicity; peripheral nerve; mechanisms; axonal and myelin damage; risk factors; toxic substances; diagnosis; rehabilitation

Special Issue Information

Dear Colleagues,

The exposure to toxic agents can frequently cause nerve damage leading to neuropathy. These agents may include drugs (antibiotics, antiretroviral agents, cardiac medications, chemotherapy, chloroquine, hydroxychloroquine, lithium, TNF-alpha inhibitors, and warfare drugs, for example), organic solvents, heavy metals, alcohol, biologicals, and other substances.

Most mechanisms of toxic neuropathy include axonal degeneration, impairment of axonal transport, damage of myelin and of peripheral neuron energy metabolism, as well as toxicity at Ranvier node, ion channels, and small fibers. Clinically, patients may suffer from numbness, tingling, pain, walking difficulties, sensory deficits, autonomic and motor disturbances, weakness, and often from neuropathic pain, which make toxic neuropathy difficult to diagnose. Symptoms usually have an insidious onset, sometimes shortly after exposure to toxics.

This Special Issue aims to highlight the research on the established knowledge as well as on open issues regarding toxic neuropathy. Studies that report insights into:

  • The mechanisms of toxic neuropathies of all types and origins (accidental or not accidental exposure to toxic substances) as well as on the evaluation and discussion of the risk factors and susceptibilities (e.g., genetic, environment, patients’ history and social condition, pre-existing neuropathy);
  • The indirect mechanisms of neuropathy development, discussing subtle ways of contracting the disease (e.g., aerosols, environment, nutrition);
  • The diagnosis, preventive strategies, time course of the disease, as well as the available and experimental therapeutic options;
  • The improvement of the awareness of toxic neuropathies and the identification of medical conditions;
  • Rehabilitation, medical, and social solutions

are encouraged. Preclinical and clinical research as well as translational research are welcome.

Authors are invited to submit original research papers, reviews, and short communications with no limitations in terms of number of pages or words. Moreover, tables and figures that can help in summarizing and/or focusing on important issues can be added in support of the text.

Dr. Valentina Alda Carozzi
Prof. Dr. Wolfgang Grisold
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurotoxicity
  • peripheral nerve
  • mechanisms
  • axonal and myelin damage
  • risk factors
  • toxic substances
  • diagnosis
  • rehabilitation

Published Papers (1 paper)

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Review

Open AccessReview
The Role of Protein Adduction in Toxic Neuropathies of Exogenous and Endogenous Origin
Toxics 2021, 9(5), 98; https://doi.org/10.3390/toxics9050098 - 29 Apr 2021
Viewed by 203
Abstract
The peripheral (axonal) neuropathy associated with repeated exposure to aliphatic and aromatic solvents that form protein-reactive γ-diketones shares some clinical and neuropathological features with certain metabolic neuropathies, including type-II diabetic neuropathy and uremic neuropathy, and with the largely sub-clinical nerve damage associated with [...] Read more.
The peripheral (axonal) neuropathy associated with repeated exposure to aliphatic and aromatic solvents that form protein-reactive γ-diketones shares some clinical and neuropathological features with certain metabolic neuropathies, including type-II diabetic neuropathy and uremic neuropathy, and with the largely sub-clinical nerve damage associated with old age. These conditions may be linked by metabolites that adduct and cross-link neuroproteins required for the maintenance of axonal transport and nerve fiber integrity in the peripheral and central nervous system. Full article
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Mechanisms of neurotoxicity associated with exposure to the herbicide atrazine
Authors: Jennifer L. Freeman
Affiliation: School of Health Sciences, Purdue University
Abstract: The review will focus on neurological targets of toxicity associated with exposure to the agricultural herbicide atrazine. Atrazine is reported to interfere with several endocrine axes and neurotransmission pathways, but the specific neurological target of toxicity is yet to be defined. We will synthesize the contemporary literature on atrazine neurotoxicity and discuss relationships between neuroendocrine and neurotransmission affected outcomes. We will integrate previous atrazine neurotoxicity studies and targets of toxicity to hypothesize mechanisms by which atrazine could disrupt these health outcomes. We will include findings from human environmental epidemiological, whole animal models (rodent, zebrafish, frog), and in vitro cellular studies.

Title: Engineering stem cell niche as a strategy against oxaliplatin-induced neuropathy
Authors: Lorenzo Di Cesare Mannelli
Affiliation: Universita degli Studi di Firenze, Florence, Italy

Title: Role of ion channels in Chemotherapy-induced peripheral neuropathy
Authors: Guido Cavaletti
Affiliation: School of Medicine and Surgery - University of Milano Bicocca, Italy

Title: Mechanisms of toxic neuropathy
Authors: Wolfgang Grisold
Affiliation: Ludwig Boltzmann Institute for Experimental und Clinical Traumatology, Vienna, Austria

Title: In Search of an In Vitro Model for chemotherapy-induced peripheral neuropathy
Authors: Sandy Eldridge/Arianna Scuteri
Affiliation: UNIMIB Department of Neurosciences and Biomedical Technologies Milano

Title: Determining the  TCR repertoire to Toxic neuropathological agents using an AI approach
Authors: Michel Mickael
Affiliation: Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, ul. Postepu 36A, Jastrzębiec, 05-552 Magdalenka, Poland

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