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Toxics, Volume 9, Issue 5

2021 May - 26 articles

Cover Story: Understudied per- and polyfluoroalkyl substances (PFAS) known as short-chain perfluoroether acids have been identified in the Cape Fear River (CFR) of North Carolina and have raised environmental health concerns. The CFR is a source of drinking water, and very little toxicological data exist for these understudied PFAS. Much of the epidemiological and toxicological data have centered on perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), and other long-chain PFAS. Exposure to PFOA and PFOS have been linked to adverse health outcomes, including suppression of immune responses, such as in reduced antibody response to vaccines. In our studies, we evaluated the immunotoxic potential of these understudied short-chain PFAS using an array of descriptive and functional immunotoxicological outcomes. View this paper.
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Articles (26)

  • Article
  • Open Access
22 Citations
4,453 Views
17 Pages

Full Factorial Design for Gold Recovery from Industrial Solutions

  • Maria Mihăilescu,
  • Adina Negrea,
  • Mihaela Ciopec,
  • Petru Negrea,
  • Narcis Duțeanu,
  • Ion Grozav,
  • Paula Svera,
  • Cosmin Vancea,
  • Alina Bărbulescu and
  • Cristian Ștefan Dumitriu

20 May 2021

Gold is one of the precious metals with multiple uses, whose deposits are much smaller than the global production needs. Therefore, extracting maximum gold quantities from industrial diluted solutions is a must. Am-L-GA is a new material, obtained by...

  • Communication
  • Open Access
2 Citations
3,120 Views
11 Pages

Toxic Effects of Docosahexaenoic Acid Treatment in the Rat Liver BRL-3A Cell

  • Wenli Luo,
  • Li Li,
  • Weina Xu,
  • Jing Zhang and
  • Jianxiong Xu

20 May 2021

The cytotoxicity of docosahexaenoic acid (DHA) on normal cells is still unclear. This study investigated the effects of DHA on the cytotoxicity and possible mechanism in the BRL-3A cell. The cultured rat liver BRL-3A cell line was treated with 50, 10...

  • Article
  • Open Access
85 Citations
6,025 Views
19 Pages

Synergistic Effects of Zinc Oxide Nanoparticles and Bacteria Reduce Heavy Metals Toxicity in Rice (Oryza sativa L.) Plant

  • Nazneen Akhtar,
  • Sehresh Khan,
  • Shafiq Ur Rehman,
  • Zia Ur Rehman,
  • Amana Khatoon,
  • Eui Shik Rha and
  • Muhammad Jamil

20 May 2021

Heavy metals (HMs) are toxic elements which contaminate the water bodies in developing countries because of their excessive discharge from industrial zones. Rice (Oryza sativa L) crops are submerged for a longer period of time in water, so irrigation...

  • Feature Paper
  • Article
  • Open Access
25 Citations
5,217 Views
15 Pages

Salinity Alters Toxicity of Commonly Used Pesticides in a Model Euryhaline Fish Species (Menidia beryllina)

  • Sara J. Hutton,
  • Scott J. St. Romain,
  • Emily I. Pedersen,
  • Samreen Siddiqui,
  • Patrick E. Chappell,
  • J. Wilson White,
  • Kevin L. Armbrust and
  • Susanne M. Brander

20 May 2021

Changing salinity in estuaries due to sea level rise and altered rainfall patterns, as a result of climate change, has the potential to influence the interactions of aquatic pollutants as well as to alter their toxicity. From a chemical property poin...

  • Communication
  • Open Access
4 Citations
2,361 Views
8 Pages

Increased PACAP- and DβH-Positive Hepatic Nerve Fibers after Bisphenol A Exposure

  • Michael Thoene,
  • Liliana Rytel,
  • Ewa Dzika and
  • Joanna Wojtkiewicz

18 May 2021

Bisphenol A (BPA) is an endocrine-disrupting compound (EDC) that can be found nearly everywhere in our polluted world. BPA has been correlated with pathophysiologies that include psychological disorders, especially in children. This study used juveni...

  • Perspective
  • Open Access
62 Citations
11,653 Views
8 Pages

Are Honey Bees at Risk from Microplastics?

  • Yahya Al Naggar,
  • Markus Brinkmann,
  • Christie M. Sayes,
  • Saad N. AL-Kahtani,
  • Showket A. Dar,
  • Hesham R. El-Seedi,
  • Bernd Grünewald and
  • John P. Giesy

15 May 2021

Microplastics (MPs) are ubiquitous and persistent pollutants, and have been detected in a wide variety of media, from soils to aquatic systems. MPs, consisting primarily of polyethylene, polypropylene, and polyacrylamide polymers, have recently been...

  • Article
  • Open Access
7 Citations
3,238 Views
17 Pages

Clastogenicity and Aneugenicity of 1,4-Benzoquinone in Different Lineages of Mouse Hematopoietic Stem/Progenitor Cells

  • Paik Wah Chow,
  • Zariyantey Abd Hamid,
  • Ramya Dewi Mathialagan,
  • Nor Fadilah Rajab,
  • Salwati Shuib and
  • Sarina Sulong

12 May 2021

Previous reports on hematotoxicity and leukemogenicity related to benzene exposure highlighted its adverse effects on hematopoiesis. Despite the reported findings, studies concerning the mechanism of benzene affecting chromosomal integrity in lineage...

  • Article
  • Open Access
25 Citations
4,654 Views
12 Pages

Short-Term Exposure to Ambient Air Pollution and Increased Emergency Room Visits for Skin Diseases in Beijing, China

  • Wanzhou Wang,
  • Wenlou Zhang,
  • Jingjing Zhao,
  • Hongyu Li,
  • Jun Wu,
  • Furong Deng,
  • Qingbian Ma and
  • Xinbiao Guo

12 May 2021

Skin diseases have become a global concern. This study aims to evaluate the associations between ambient air pollution and emergency room visits for skin diseases under the background of improving air quality in China. Based on 45,094 cases from a ge...

  • Article
  • Open Access
92 Citations
12,194 Views
11 Pages

Perfluoroalkylated Substances (PFAS) Associated with Microplastics in a Lake Environment

  • John W. Scott,
  • Kathryn G. Gunderson,
  • Lee A. Green,
  • Richard R. Rediske and
  • Alan D. Steinman

11 May 2021

The presence of both microplastics and per- and polyfluoroalkyl substances (PFAS) is ubiquitous in the environment. The ecological impacts associated with their presence are still poorly understood, however, these contaminants are extremely persisten...

  • Article
  • Open Access
22 Citations
3,849 Views
15 Pages

In-Vitro and In-Vivo Tolerance and Therapeutic Investigations of Phyto-Fabricated Iron Oxide Nanoparticles against Selected Pathogens

  • Amreen Shah,
  • Isfahan Tauseef,
  • Manel Ben Ali,
  • Muhammad Arfat Yameen,
  • Amine Mezni,
  • Amor Hedfi,
  • Syed Kashif Haleem and
  • Sirajul Haq

8 May 2021

The Paeonia emodi (P. emodi)-mediated iron oxide nanoparticles (Fe2O3 NPs) were screened for in-vitro and in-vivo antibacterial activity against the Staphylococcus aureus (S. aureus) (ATCC #: 6538) and Escherichia coli (E. coli) (ATCC #:15224). The s...

  • Article
  • Open Access
10 Citations
3,979 Views
17 Pages

Assessing Combined Effects for Mixtures of Similar and Dissimilar Acting Neuroactive Substances on Zebrafish Embryo Movement

  • Afolarin O. Ogungbemi,
  • Riccardo Massei,
  • Rolf Altenburger,
  • Stefan Scholz and
  • Eberhard Küster

6 May 2021

Risk assessment of chemicals is usually conducted for individual chemicals whereas mixtures of chemicals occur in the environment. Considering that neuroactive chemicals are a group of contaminants that dominate the environment, it is then imperative...

  • Article
  • Open Access
40 Citations
4,765 Views
21 Pages

4 May 2021

The green chemistry method is the preferred approach for synthesizing metal and metal oxide nanoparticles because of its low toxicity, environmental friendliness, feasibility, and safety to human health compared with other chemical or physical method...

  • Article
  • Open Access
19 Citations
5,664 Views
17 Pages

Phytochemical and Safety Evaluations of Zingiber ottensii Valeton Essential Oil in Zebrafish Embryos and Rats

  • Wisit Thitinarongwate,
  • Raktham Mektrirat,
  • Wutigri Nimlamool,
  • Parirat Khonsung,
  • Surachai Pikulkaew,
  • Siriporn Okonogi and
  • Puongtip Kunanusorn

3 May 2021

Zingiber ottensii Valeton (ZO) exhibits pharmacological activity and has long been used in traditional medicine. However, reports about its safety profiles are limited. The present study aimed to evaluate the phytochemical profile and the toxic effec...

  • Feature Paper
  • Article
  • Open Access
13 Citations
5,688 Views
17 Pages

Validation of a Method Scope Extension for the Analysis of POPs in Soil and Verification in Organic and Conventional Farms of the Canary Islands

  • Andrea Acosta-Dacal,
  • Cristian Rial-Berriel,
  • Ricardo Díaz-Díaz,
  • María del Mar Bernal-Suárez,
  • Manuel Zumbado,
  • Luis Alberto Henríquez-Hernández,
  • Pablo Alonso-González,
  • Eva Parga-Dans and
  • Octavio P. Luzardo

2 May 2021

Persistent organic pollutants (POPs) are among the most relevant and dangerous contaminants in soil, from where they can be transferred to crops. Additionally, livestock animals may inadvertently consume relatively high amounts of soil attached to th...

  • Feature Paper
  • Article
  • Open Access
48 Citations
9,757 Views
14 Pages

1 May 2021

Novel per- and polyfluoroalkyl substances (PFAS) were recently identified in drinking water sources throughout North Carolina. These include the perfluoroether acids (PFEAs) perfluoro-2-methoxyacetic acid (PFMOAA), perfluoro-2-methoxypropanoic acid (...

  • Article
  • Open Access
21 Citations
3,858 Views
14 Pages

Organophosphate Pesticide Exposures in Early and Late Pregnancy Influence Different Aspects of Infant Developmental Performance

  • Boonsita Suwannakul,
  • Ratana Sapbamrer,
  • Natrujee Wiwattanadittakul and
  • Surat Hongsibsong

30 April 2021

Organophosphate (OP) pesticides can transfer from mother to fetus via the placenta and amniotic fluid and may affect the development of infants. This study aims to evaluate the associations between maternal OP concentrations collected in the 1st–2nd...

  • Feature Paper
  • Review
  • Open Access
9 Citations
3,853 Views
19 Pages

29 April 2021

The peripheral (axonal) neuropathy associated with repeated exposure to aliphatic and aromatic solvents that form protein-reactive γ-diketones shares some clinical and neuropathological features with certain metabolic neuropathies, including type-II...

  • Article
  • Open Access
40 Citations
4,697 Views
24 Pages

Cellular Uptake and Toxicological Effects of Differently Sized Zinc Oxide Nanoparticles in Intestinal Cells

  • Anna Mittag,
  • Christian Hoera,
  • Alexander Kämpfe,
  • Martin Westermann,
  • Jochen Kuckelkorn,
  • Thomas Schneider and
  • Michael Glei

27 April 2021

Due to their beneficial properties, the use of zinc oxide nanoparticles (ZnO NP) is constantly increasing, especially in consumer-related areas, such as food packaging and food additives, which is leading to an increased oral uptake of ZnO NP. Conseq...

  • Feature Paper
  • Article
  • Open Access
1 Citations
5,511 Views
19 Pages

In Silico Exploration of the Potential Role of Acetaminophen and Pesticides in the Etiology of Autism Spectrum Disorder

  • Tristan Furnary,
  • Rolando Garcia-Milian,
  • Zeyan Liew,
  • Shannon Whirledge and
  • Vasilis Vasiliou

27 April 2021

Recent epidemiological studies suggest that prenatal exposure to acetaminophen (APAP) is associated with increased risk of Autism Spectrum Disorder (ASD), a neurodevelopmental disorder affecting 1 in 59 children in the US. Maternal and prenatal expos...

  • Article
  • Open Access
38 Citations
5,825 Views
17 Pages

Assessment of Metals Concentrations in Soils of Abu Dhabi Emirate Using Pollution Indices and Multivariate Statistics

  • Yousef Nazzal,
  • Alina Bărbulescu,
  • Fares Howari,
  • Ahmed A. Al-Taani,
  • Jibran Iqbal,
  • Cijo M. Xavier,
  • Manish Sharma and
  • Cristian Ștefan Dumitriu

25 April 2021

The aim of this study was twofold. Firstly, we performed a land capability class determination of the agricultural soils from the Abu Dhabi Emirate, the United Arab Emirates, based on the concentrations of 17 chemical elements determined in the soil...

  • Article
  • Open Access
12 Citations
3,812 Views
12 Pages

Zinc, Zinc Transporters, and Cadmium Cytotoxicity in a Cell Culture Model of Human Urothelium

  • Soisungwan Satarug,
  • Scott H. Garrett,
  • Seema Somji,
  • Mary Ann Sens and
  • Donald A. Sens

24 April 2021

We explored the potential role of zinc (Zn) and zinc transporters in protection against cytotoxicity of cadmium (Cd) in a cell culture model of human urothelium, named UROtsa. We used real-time qRT-PCR to quantify transcript levels of 19 Zn transport...

  • Article
  • Open Access
22 Citations
3,702 Views
20 Pages

Total and Metabolically Active Microbial Community of Aerobic Granular Sludge Systems Operated in Sequential Batch Reactors: Effect of Pharmaceutical Compounds

  • Barbara Muñoz-Palazon,
  • Aurora Rosa-Masegosa,
  • Miguel Hurtado-Martinez,
  • Alejandro Rodriguez-Sanchez,
  • Alexander Link,
  • Ramiro Vilchez-Vargas,
  • Alejandro Gonzalez-Martinez and
  • Jesus Gonzalez Lopez

23 April 2021

Two aerobic granular sludge (AGS) sequential batch reactors were operated at a mild (15 °C) temperature for 180 days. One of those bioreactors was exposed to a mixture of diclofenac, naproxen, trimethoprim, and carbamazepine. The AGS system, operatin...

  • Article
  • Open Access
20 Citations
3,847 Views
10 Pages

21 April 2021

Iodine deficiency is the main environmental factor leading to thyroid cancer. At the same time iodine excess may also contribute to thyroid cancer. Potassium iodate (KIO3), which is broadly used in salt iodization program, may increase oxidative dama...

  • Article
  • Open Access
15 Citations
4,070 Views
16 Pages

Phthalate Exposures in the Neonatal Intensive Care Unit

  • Randall Jenkins,
  • Devlynne Ondusko,
  • Luke Montrose,
  • Ryan Forbush and
  • David Rozansky

21 April 2021

Background: Di-2-ethylhexyl phthalate (DEHP), a phthalate compound found in medical devices, may cause toxic effects in premature infants. In this study, the objective is to quantify DEHP exposures from various intravenous and respiratory therapy dev...

  • Feature Paper
  • Article
  • Open Access
15 Citations
4,012 Views
17 Pages

Co-Cropping Indian Mustard and Silage Maize for Phytoremediation of a Cadmium-Contaminated Acid Paddy Soil Amended with Peat

  • Sifan Wang,
  • Yong Liu,
  • Khalil Kariman,
  • Jialin Li,
  • Huihua Zhang,
  • Fangbai Li,
  • Yinglong Chen,
  • Chongjian Ma,
  • Chuanping Liu and
  • Zed Rengel
  • + 2 authors

21 April 2021

Co-cropping is an eco-friendly strategy to improve the phytoremediation capacity of plants growing in soils contaminated with heavy metals such as cadmium (Cd). This study was conducted to investigate the effects of co-cropping Indian mustard (Brassi...

  • Article
  • Open Access
42 Citations
6,157 Views
16 Pages

Cytotoxicity and Microbicidal Activity of Commonly Used Organic Solvents: A Comparative Study and Application to a Standardized Extract from Vaccinium macrocarpon

  • Yana Ilieva,
  • Lyudmila Dimitrova,
  • Maya Margaritova Zaharieva,
  • Mila Kaleva,
  • Petko Alov,
  • Ivanka Tsakovska,
  • Tania Pencheva,
  • Ivanka Pencheva-El Tibi,
  • Hristo Najdenski and
  • Ilza Pajeva

21 April 2021

The cytotoxicity and microbicidal capacity of seven organic solvents commonly applied for studying plant extracts and bioactive compounds were systematically investigated based on international standards. Four cell lines of normal (CCL-1, HaCaT) or t...

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Toxics - ISSN 2305-6304