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Article

Effects of Acrylamide-Induced Vasorelaxation and Neuromuscular Blockage: A Rodent Study

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Department of Medical Research, Human Genetic Center, School of Post-Baccalaureate Chinese Medicine, China Medical University Hospital, Taichung 404, Taiwan
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School of Nutrition, Chung Shan Medical University Hospital, Taichung 402, Taiwan
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Graduate Institute of Food Safety, National Chung Hsing University, Taichung 402, Taiwan
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Bachelor Program of Biotechnology, National Chung Hsing University, Taichung 402, Taiwan
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Department of Medical Research, Human Genetic Center, School of Chinese Medicine, China Medical University Hospital, Taichung 404, Taiwan
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Department of Biotechnology and Bioinformatics, Asia University, Taichung 413, Taiwan
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Graduate Institute of Veterinary Pathobiology, National Chung Hsing University, Taichung 402, Taiwan
*
Authors to whom correspondence should be addressed.
Academic Editor: Janneke Hogervorst
Toxics 2021, 9(6), 117; https://doi.org/10.3390/toxics9060117
Received: 8 March 2021 / Revised: 9 May 2021 / Accepted: 20 May 2021 / Published: 24 May 2021
Acrylamide (ACR), which is formed during the Maillard reaction, is used in various industrial processes. ACR accumulation in humans and laboratory animals results in genotoxicity, carcinogenicity, neurotoxicity, and reproductive toxicity. In this study, we investigated the mechanisms by which ACR may induce vasorelaxation and neuromuscular toxicity. Vasorelaxation was studied using an isolated rat aortic ring model. The aortic rings were divided into the following groups: with or without endothelium, with nitric oxide synthase (NOS) inhibition, with acetylcholine receptor inhibition, and with extracellular calcium inhibition. Changes in tension were used to indicate vasorelaxation. Neuromuscular toxicity was assessed using a phrenic nerve–diaphragm model. Changes in muscle contraction stimulated by the phrenic nerve were used to indicate neuromuscular toxicity. ACR induced the vasorelaxation of phenylephrine-precontracted aortic rings, which could be significantly attenuated by NOS inhibitors. The results of the phrenic nerve–diaphragm experiments revealed that ACR reduced muscle stimulation and contraction through nicotinic acetylcholine receptor (AChR). ACR-induced vasotoxicity was regulated by NOS through the aortic endothelium. Nicotinic AChR regulated ACR-induced neuromuscular blockage. View Full-Text
Keywords: acrylamide; vasorelaxation; neurotoxicity; nitric oxide synthase; nicotinic acetylcholine receptor acrylamide; vasorelaxation; neurotoxicity; nitric oxide synthase; nicotinic acetylcholine receptor
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MDPI and ACS Style

Lin, W.-D.; Ou, C.-C.; Hsiao, S.-H.; Chang, C.-H.; Tsai, F.-J.; Liao, J.-W.; Chen, Y.-T. Effects of Acrylamide-Induced Vasorelaxation and Neuromuscular Blockage: A Rodent Study. Toxics 2021, 9, 117. https://doi.org/10.3390/toxics9060117

AMA Style

Lin W-D, Ou C-C, Hsiao S-H, Chang C-H, Tsai F-J, Liao J-W, Chen Y-T. Effects of Acrylamide-Induced Vasorelaxation and Neuromuscular Blockage: A Rodent Study. Toxics. 2021; 9(6):117. https://doi.org/10.3390/toxics9060117

Chicago/Turabian Style

Lin, Wei-De, Chu-Chyn Ou, Shih-Hao Hsiao, Chih-Han Chang, Fuu-Jen Tsai, Jiunn-Wang Liao, and Yng-Tay Chen. 2021. "Effects of Acrylamide-Induced Vasorelaxation and Neuromuscular Blockage: A Rodent Study" Toxics 9, no. 6: 117. https://doi.org/10.3390/toxics9060117

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