Special Issue "Dysbiosis of Gut Microbiota by Environmental Pollutants: Implications for Host Health"

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Toxicology".

Deadline for manuscript submissions: 31 July 2022 | Viewed by 2343

Special Issue Editor

Dr. Lianguo Chen
E-Mail Website
Guest Editor
State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China
Interests: aquatic toxicology; persistent organic pollutants; ecological risk assessment; toxic mechanisms; adverse outcome pathway

Special Issue Information

Dear Colleagues,

There is accumulating evidence that verifies the fundamental roles of gut microbiota in the maintenance of host health and wellbeing. Alterations in the composition, diversity and metabolism of gut commensal microbes will compromise the physiological functions of host animals, ultimately leading to the pathogenesis of various diseases, including systemic inflammation, obesity, diabetes, and neurobehavioral disorders. It is notable that dynamics of the gut microbial community are susceptible to environmental stressors, especially toxic pollutants, which are potent to shift the gut microbiota and interrupt the physiological activities of hosts. However, the mechanisms and potential of environmental pollutants to shape the gut microbial community population remain less investigated. In particular, more effort is needed to establish the extrapolation of gut microbiome dysbiosis to host health, thereby providing a novel explanation about the mode of toxic action of environmental pollutants.

To this end, this Special Issue focuses on the original studies, reviews and short communications that are designed to explore the toxic effects of environmental pollutants on gut microbiota. Environmental pollutants include, but are not limited to, persistent organic pollutants, antibiotics, nanoparticles and metals. Research studies that are able to provide mechanistic insight into gut microbiota disturbances by pollutants and elucidate the underlying implications to host health are especially welcome.

Dr. Lianguo Chen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • gut microbiota
  • host health
  • environmental pollutants
  • gut–liver axis
  • gut–brain axis
  • mode of toxic action

Published Papers (2 papers)

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Gut Microbiota Manipulation to Mitigate the Detrimental Effects of Environmental Pollutants
Toxics 2021, 9(6), 127; https://doi.org/10.3390/toxics9060127 - 01 Jun 2021
Cited by 7 | Viewed by 1088
The ecotoxicology and human health risks of environmental pollutants are creating global concern, especially in the context of the prevalent and severe contamination of environmental abiotic and biotic compartments [...] Full article


Jump to: Editorial

Sub-Chronic Difenoconazole Exposure Induced Gut Microbiota Dysbiosis in Mice
Toxics 2022, 10(1), 34; https://doi.org/10.3390/toxics10010034 - 12 Jan 2022
Viewed by 825
Difenoconazole (DIF) is a widely separated triazole fungicide in many countries. The excessive usage of DIF increases the high volume of residues in agriculture production and water bodies. Some previous studies demonstrated the toxic effects of DIF on non-target animals, however, there were [...] Read more.
Difenoconazole (DIF) is a widely separated triazole fungicide in many countries. The excessive usage of DIF increases the high volume of residues in agriculture production and water bodies. Some previous studies demonstrated the toxic effects of DIF on non-target animals, however, there were still some gaps in the knowledge of the potential hazards of DIF to mammals and human health. Herein, 7-week-old male mice were exposed to 30 and 100 mg/kg/day DIF for 14 and 56 days. We observed that 56 days of DIF exposure decreased the colonic mucus expression of alcin blue-periodic acid-schiff (AB-PAS) stain and the immunochemical stain of muc2 protein. The transcript levels of mucin protein (muc1, muc2 and muc3) decreased significantly in the gut of mice followed 56 days of 100 mg/kg/day DIF exposure. In addition, the gut microbiota composition was also affected after 14 or 56 days of DIF exposure. Although the mucus expression after 14 days of DIF exposure only decreased slightly, the gut microbiota composition compared with the control group was changed significantly. Moreover, the DIF-30 and DIF-100 caused respectively different changes on the gut microbiota. The relative abundance of Bacteroidetes decreased significantly after 14 days and 56 days of DIF exposure. After 14 days of DIF exposure, there were 35 and 18 differential genera in the DIF-30 and DIF-100 group, respectively. There were 25 and 32 differential genera in the DIF-30 and DIF-100 group after 56 days of exposure, respectively. Meanwhile, the alpha diversity indexes, including observed species, Shannon, Simpson, Chao1 and ACE, in gut microbiota decreased significantly after 56 days of DIF exposure. Interestingly, the relative abundance of Akkermansia increased significantly after 56 days of 100 mg/kg/d DIF exposure. Although Akkermansia was considered as one probiotic, the phenomenon of dramatic Akkermansia increase with the decrease in gut microbiota diversity needed further discussion. These results provided some new insights on how DIF exposure impacts the mucus barrier and induces gut microbiota dysbiosis. Full article
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