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Toxics, Volume 9, Issue 4

April 2021 - 20 articles

Cover Story: Characterization of the DNA adductome can provide valuable information in toxicological assessment. Methods for measurement of DNA adducts utilizing liquid chromatography coupled to high-resolution mass spectrometry (HRMS), to obtain high selectivity, are being developed by us and elsewhere. A challenging aspect in the adductomics methodology has been the processing of MS data files to find DNA adducts that are still unknown. To combat this challenge, we have developed the nLossFinder program that can screen for DNA adducts by tracking a characteristic neutral loss with high mass accuracy. The HRMS-based approach for DNA adductomics developed in this work can possibly be adapted for any DNA sample and aid in the identification of new modifications in the (epi)genome. View this paper
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Articles (20)

  • Article
  • Open Access
16 Citations
13,720 Views
13 Pages

20 April 2021

Pharmaceuticals and hormones (PhACs) enter the aquatic environment in multiple ways, posing potential adverse effects on non-target organisms. They have been widely detected in drinking water sources, challenging water companies to reassure good qual...

  • Article
  • Open Access
5 Citations
3,686 Views
16 Pages

18 April 2021

Flavoring agents are added to cigarettes to improve taste. There are mostly permitted food additives, but some of them are restricted for use in food, cosmetics, and toys, since they can cause allergic reactions. Previous studies have investigated th...

  • Article
  • Open Access
4 Citations
3,950 Views
18 Pages

Trace Level Determination of Saccharides in Pristine Marine Aerosols by Gas Chromatography—Tandem Mass Spectrometry

  • Na-Rae Choi,
  • Yong-Jun Yoon,
  • Ki-Tae Park,
  • Ki-Ae Kim,
  • Yong-Pyo Kim,
  • Yun-Gyong Ahn and
  • Ji-Yi Lee

17 April 2021

The quantification and identification of saccharides in pristine marine aerosols can provide useful information for determining the contributions of anthropogenic and natural sources of the aerosol. However, individual saccharide compounds in pristin...

  • Systematic Review
  • Open Access
34 Citations
7,362 Views
15 Pages

16 April 2021

Background: About half of the population in developing countries are exposed to indoor pollution such as combustion fuels at present. Chronic obstructive pulmonary disease (COPD) is one of the leading causes of mortality globally and the primary caus...

  • Feature Paper
  • Article
  • Open Access
29 Citations
4,756 Views
15 Pages

15 April 2021

Overuse of antibiotics has resulted in widespread contamination of the environment and triggered antibiotic resistance in pathogenic bacteria. Conventional wastewater treatment plants (WWTPs) are not equipped to remove antibiotics. Effluents from WWT...

  • Feature Paper
  • Article
  • Open Access
9 Citations
4,184 Views
18 Pages

An Easy Procedure to Quantify Anticoagulant Rodenticides and Pharmaceutical Active Compounds in Soils

  • Andrea Acosta-Dacal,
  • Cristian Rial-Berriel,
  • Ricardo Díaz-Díaz,
  • María del Mar Bernal-Suárez,
  • Manuel Zumbado,
  • Luis Alberto Henríquez-Hernández and
  • Octavio P. Luzardo

10 April 2021

A modified QuEChERS (quick, easy, cheap, effective, rugged, and safe) extraction was validated for the extraction of seven coumarin anticoagulant rodenticides (ARs) and 36 pharmaceutical active compounds (PhACs) residues in soil samples using liquid...

  • Article
  • Open Access
14 Citations
4,174 Views
14 Pages

Comparison of Simultaneous Quantitative Analysis of Methylmercury and Inorganic Mercury in Cord Blood Using LC-ICP-MS and LC-CVAFS: The Pilot Study of the Japan Environment and Children’s Study

  • Miyuki Iwai-Shimada,
  • Yayoi Kobayashi,
  • Tomohiko Isobe,
  • Shoji F. Nakayama,
  • Makiko Sekiyama,
  • Yu Taniguchi,
  • Shin Yamazaki,
  • Takehiro Michikawa,
  • Masako Oda and
  • Hiroshi Mitsubuchi
  • + 6 authors

9 April 2021

Prenatal exposure to methylmercury (MeHg) affects child development after birth. However, many epidemiological studies have evaluated total mercury levels without analyzing speciation. Biomonitoring of MeHg and inorganic mercury (IHg) is essential to...

  • Article
  • Open Access
20 Citations
6,919 Views
15 Pages

Environmental Risk of Pesticides for Fish in Small- and Medium-Sized Streams of Switzerland

  • Inge Werner,
  • Anke Schneeweiss,
  • Helmut Segner and
  • Marion Junghans

8 April 2021

This study assessed the acute and chronic risk of pesticides, singly and as mixtures, for fish using comprehensive chemical data of four monitoring studies conducted in small- and medium-sized streams of Switzerland between 2012 and 2018. Pesticides...

  • Article
  • Open Access
1 Citations
2,670 Views
16 Pages

Protection and Active Decontamination of Dairy Cattle Heifers against Lipophilic Toxins (PCBs) from Diet

  • Alexander Sotnichenko,
  • Elena Tsis,
  • Magomed Chabaev,
  • Vasily Duborezov,
  • Alexander Kochetkov,
  • Roman Nekrasov and
  • Victor Okhanov

8 April 2021

We studied the effects of a hydrophobized reversed-phase feed adsorbent in the form of a polyoctylated polysilicate hydrogel (POPSH) on productivity indicators, metabolic adaptation, and on the level of polychlorinated biphenyls (PCBs) in the blood o...

  • Article
  • Open Access
15 Citations
3,650 Views
15 Pages

Degradation Products of Polychlorinated Biphenyls and Their In Vitro Transformation by Ligninolytic Fungi

  • Kamila Šrédlová,
  • Kateřina Šírová,
  • Tatiana Stella and
  • Tomáš Cajthaml

8 April 2021

Metabolites of polychlorinated biphenyls (PCBs)—hydroxylated PCBs (OH-PCBs), chlorobenzyl alcohols (CB-OHs), and chlorobenzaldehydes (CB-CHOs)—were incubated in vitro with the extracellular liquid of Pleurotus ostreatus, which contains mainly laccase...

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Toxics - ISSN 2305-6304