Toxics, Volume 9, Issue 4 (April 2021) – 20 articles
Cover Story (view full-size image): Characterization of the DNA adductome can provide valuable information in toxicological assessment. Methods for measurement of DNA adducts utilizing liquid chromatography coupled to high-resolution mass spectrometry (HRMS), to obtain high selectivity, are being developed by us and elsewhere. A challenging aspect in the adductomics methodology has been the processing of MS data files to find DNA adducts that are still unknown. To combat this challenge, we have developed the nLossFinder program that can screen for DNA adducts by tracking a characteristic neutral loss with high mass accuracy. The HRMS-based approach for DNA adductomics developed in this work can possibly be adapted for any DNA sample and aid in the identification of new modifications in the (epi)genome. View this paper
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