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Toxics, Volume 9, Issue 4

2021 April - 20 articles

Cover Story: Characterization of the DNA adductome can provide valuable information in toxicological assessment. Methods for measurement of DNA adducts utilizing liquid chromatography coupled to high-resolution mass spectrometry (HRMS), to obtain high selectivity, are being developed by us and elsewhere. A challenging aspect in the adductomics methodology has been the processing of MS data files to find DNA adducts that are still unknown. To combat this challenge, we have developed the nLossFinder program that can screen for DNA adducts by tracking a characteristic neutral loss with high mass accuracy. The HRMS-based approach for DNA adductomics developed in this work can possibly be adapted for any DNA sample and aid in the identification of new modifications in the (epi)genome. View this paper
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Articles (20)

  • Article
  • Open Access
20 Citations
14,250 Views
13 Pages

20 April 2021

Pharmaceuticals and hormones (PhACs) enter the aquatic environment in multiple ways, posing potential adverse effects on non-target organisms. They have been widely detected in drinking water sources, challenging water companies to reassure good qual...

  • Article
  • Open Access
5 Citations
3,958 Views
16 Pages

18 April 2021

Flavoring agents are added to cigarettes to improve taste. There are mostly permitted food additives, but some of them are restricted for use in food, cosmetics, and toys, since they can cause allergic reactions. Previous studies have investigated th...

  • Article
  • Open Access
4 Citations
4,127 Views
18 Pages

Trace Level Determination of Saccharides in Pristine Marine Aerosols by Gas Chromatography—Tandem Mass Spectrometry

  • Na-Rae Choi,
  • Yong-Jun Yoon,
  • Ki-Tae Park,
  • Ki-Ae Kim,
  • Yong-Pyo Kim,
  • Yun-Gyong Ahn and
  • Ji-Yi Lee

17 April 2021

The quantification and identification of saccharides in pristine marine aerosols can provide useful information for determining the contributions of anthropogenic and natural sources of the aerosol. However, individual saccharide compounds in pristin...

  • Systematic Review
  • Open Access
34 Citations
8,026 Views
15 Pages

16 April 2021

Background: About half of the population in developing countries are exposed to indoor pollution such as combustion fuels at present. Chronic obstructive pulmonary disease (COPD) is one of the leading causes of mortality globally and the primary caus...

  • Feature Paper
  • Article
  • Open Access
31 Citations
5,105 Views
15 Pages

15 April 2021

Overuse of antibiotics has resulted in widespread contamination of the environment and triggered antibiotic resistance in pathogenic bacteria. Conventional wastewater treatment plants (WWTPs) are not equipped to remove antibiotics. Effluents from WWT...

  • Feature Paper
  • Article
  • Open Access
9 Citations
4,590 Views
18 Pages

An Easy Procedure to Quantify Anticoagulant Rodenticides and Pharmaceutical Active Compounds in Soils

  • Andrea Acosta-Dacal,
  • Cristian Rial-Berriel,
  • Ricardo Díaz-Díaz,
  • María del Mar Bernal-Suárez,
  • Manuel Zumbado,
  • Luis Alberto Henríquez-Hernández and
  • Octavio P. Luzardo

10 April 2021

A modified QuEChERS (quick, easy, cheap, effective, rugged, and safe) extraction was validated for the extraction of seven coumarin anticoagulant rodenticides (ARs) and 36 pharmaceutical active compounds (PhACs) residues in soil samples using liquid...

  • Article
  • Open Access
14 Citations
4,534 Views
14 Pages

Comparison of Simultaneous Quantitative Analysis of Methylmercury and Inorganic Mercury in Cord Blood Using LC-ICP-MS and LC-CVAFS: The Pilot Study of the Japan Environment and Children’s Study

  • Miyuki Iwai-Shimada,
  • Yayoi Kobayashi,
  • Tomohiko Isobe,
  • Shoji F. Nakayama,
  • Makiko Sekiyama,
  • Yu Taniguchi,
  • Shin Yamazaki,
  • Takehiro Michikawa,
  • Masako Oda and
  • Masayuki Shimono
  • + 6 authors

9 April 2021

Prenatal exposure to methylmercury (MeHg) affects child development after birth. However, many epidemiological studies have evaluated total mercury levels without analyzing speciation. Biomonitoring of MeHg and inorganic mercury (IHg) is essential to...

  • Article
  • Open Access
22 Citations
7,352 Views
15 Pages

Environmental Risk of Pesticides for Fish in Small- and Medium-Sized Streams of Switzerland

  • Inge Werner,
  • Anke Schneeweiss,
  • Helmut Segner and
  • Marion Junghans

8 April 2021

This study assessed the acute and chronic risk of pesticides, singly and as mixtures, for fish using comprehensive chemical data of four monitoring studies conducted in small- and medium-sized streams of Switzerland between 2012 and 2018. Pesticides...

  • Article
  • Open Access
1 Citations
2,833 Views
16 Pages

Protection and Active Decontamination of Dairy Cattle Heifers against Lipophilic Toxins (PCBs) from Diet

  • Alexander Sotnichenko,
  • Elena Tsis,
  • Magomed Chabaev,
  • Vasily Duborezov,
  • Alexander Kochetkov,
  • Roman Nekrasov and
  • Victor Okhanov

8 April 2021

We studied the effects of a hydrophobized reversed-phase feed adsorbent in the form of a polyoctylated polysilicate hydrogel (POPSH) on productivity indicators, metabolic adaptation, and on the level of polychlorinated biphenyls (PCBs) in the blood o...

  • Article
  • Open Access
17 Citations
3,895 Views
15 Pages

Degradation Products of Polychlorinated Biphenyls and Their In Vitro Transformation by Ligninolytic Fungi

  • Kamila Šrédlová,
  • Kateřina Šírová,
  • Tatiana Stella and
  • Tomáš Cajthaml

8 April 2021

Metabolites of polychlorinated biphenyls (PCBs)—hydroxylated PCBs (OH-PCBs), chlorobenzyl alcohols (CB-OHs), and chlorobenzaldehydes (CB-CHOs)—were incubated in vitro with the extracellular liquid of Pleurotus ostreatus, which contains mainly laccase...

  • Feature Paper
  • Article
  • Open Access
17 Citations
4,048 Views
11 Pages

nLossFinder—A Graphical User Interface Program for the Nontargeted Detection of DNA Adducts

  • Pedro F. M. Sousa,
  • Giulia Martella,
  • K. Magnus Åberg,
  • Bahare Esfahani and
  • Hitesh V. Motwani

7 April 2021

DNA adductomics is a relatively new omics approach aiming to measure known and unknown DNA modifications, called DNA adducts. Liquid chromatography–tandem mass spectrometry (LC-MS/MS) has become the most common method for analyzing DNA adducts. Recen...

  • Feature Paper
  • Review
  • Open Access
7 Citations
4,865 Views
19 Pages

6 April 2021

Exposure to endocrine-disrupting chemicals (EDCs) is linked to myriad disorders, characterized by the disruption of the complex endocrine signaling pathways that govern development, physiology, and even behavior across the entire body. The mechanisms...

  • Article
  • Open Access
12 Citations
3,596 Views
7 Pages

2 April 2021

(1) Background: The incidence of hypertension in very low birthweight (VLBW) infants in a single neonatal intensive care unit (NICU) dropped markedly during a 2-year period when the IV fluid (IVF) in both the antenatal unit and the NICU temporarily c...

  • Article
  • Open Access
11 Citations
3,413 Views
14 Pages

Occurrence, Removal, and Mass Balance of Polycyclic Aromatic Hydrocarbons and Their Derivatives in Wastewater Treatment Plants in Northeast China

  • Rashid Mohammed,
  • Zi-Feng Zhang,
  • Chao Jiang,
  • Ying-Hua Hu,
  • Li-Yan Liu,
  • Wan-Li Ma,
  • Wei-Wei Song,
  • Anatoly Nikolaev,
  • Roland Kallenborn and
  • Yi-Fan Li

2 April 2021

Polycyclic aromatic hydrocarbons (PAHs), 33 methylated PAHs (Me-PAHs), and 14 nitrated PAHs (NPAHs) were measured in wastewater treatment plants (WWTPs) to study the removal efficiency of these compounds through the WWTPs, as well as their source app...

  • Article
  • Open Access
25 Citations
6,005 Views
17 Pages

Transition Metals in Freshwater Crustaceans, Tilapia, and Inland Water: Hazardous to the Population of the Small Island Province

  • Christine Joy M. Agarin,
  • Doreen R. Mascareñas,
  • Ronnel Nolos,
  • Eduardo Chan and
  • Delia B. Senoro

1 April 2021

This paper elaborates on the potential toxicants detected in inland water, freshwater crustaceans, and tilapia in an island that experienced mining disasters in 1993 and 1996. Specimen samples were collected in six municipalities of the island provin...

  • Article
  • Open Access
36 Citations
5,896 Views
14 Pages

Inflammatory Biomarkers Interleukin 1 Beta (IL-1β) and Tumour Necrosis Factor Alpha (TNF-α) Are Differentially Elevated in Tobacco Smoke Associated COPD and Biomass Smoke Associated COPD

  • Bellipady Shyam Prasad Shetty,
  • Sindaghatta Krishnarao Chaya,
  • Sravan Kumar V,
  • Maheswarappa Mahendra,
  • Biligere Siddaiah Jayaraj,
  • Komarla Sundararaja Lokesh,
  • Koustav Ganguly and
  • Padukudru Anand Mahesh

1 April 2021

Chronic obstructive pulmonary disease (COPD), the leading cause of mortality and morbidity worldwide, is characterized by abnormal activation of inflammatory cells. The increased pro-inflammatory cytokines, such as tumour necrosis factor alpha (TNF-α...

  • Article
  • Open Access
24 Citations
4,169 Views
11 Pages

1 April 2021

Sulfoxaflor is the first member of the neonicotinoid-sulfoximine insecticides that acts as an agonist of nicotinic acetylcholine receptors (nAChRs). This study investigated the acute effects of sulfoxaflor on acetylcholinesterase (AChE; EC 3.1.1.7) e...

  • Article
  • Open Access
8 Citations
3,241 Views
23 Pages

1 April 2021

Water is regarded as an important natural resource to sustain life, and its purification is an important criterion that determines its quality and usefulness. In this study, the incorporation of Fe3+ oxide onto a phenylenediamine (pPD) polymer matrix...

  • Article
  • Open Access
2 Citations
4,656 Views
29 Pages

Transcriptional Analyses of Acute Exposure to Methylmercury on Erythrocytes of Loggerhead Sea Turtle

  • Javier Hernández-Fernández,
  • Andrés Pinzón-Velasco,
  • Ellie Anne López,
  • Pilar Rodríguez-Becerra and
  • Leonardo Mariño-Ramírez

29 March 2021

To understand changes in enzyme activity and gene expression as biomarkers of exposure to methylmercury, we exposed loggerhead turtle erythrocytes (RBCs) to concentrations of 0, 1, and 5 mg L−1 of MeHg and de novo transcriptome were assembled using R...

  • Communication
  • Open Access
6 Citations
3,804 Views
13 Pages

Participant Experiences in a Human Biomonitoring Study: Follow-Up Interviews with Participants of the Flemish Environment and Health Study

  • Bert Morrens,
  • Hans Jonker,
  • Elly Den Hond,
  • Dries Coertjens,
  • Ann Colles,
  • Greet Schoeters,
  • Nicolas Van Larebeke,
  • Tim Nawrot,
  • Adrian Covaci and
  • Ilse Loots
  • + 2 authors

28 March 2021

Communicating individual human biomonitoring results to study participants has been the subject of debate for some time. This debate is dominated by ethical considerations from a researchers’ perspective on whether or not to communicate, thereby over...

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Toxics - ISSN 2305-6304