Special Issue "The One Health Concept: Interactions between the Health of Humans, Animals and the Environment"

A special issue of Toxics (ISSN 2305-6304).

Deadline for manuscript submissions: 30 September 2021.

Special Issue Editor

Prof. Dr. Joshua R. Edwards
E-Mail Website
Guest Editor
Department of Pharmacology, Midwestern University, 555 31st Street, Science Hall room 322-F Downers Grove, IL 60513, USA
Interests: environmental toxicology; metal toxicology; renal toxicology; biomarkers; diabetogenic substances; obesogenic substances; neuro toxicology

Special Issue Information

Dear Colleagues,

The One Health concept focuses on the interaction between the health of humans, animals, and the environment. This concept is not novel, but it has received renewed attention. Both the U.S. Center for Disease Control and the World Health Organization have online resources for One Health. Relatively recent fundamental shifts in our world have occurred or have begun to occur, such as climate change, globalization, and increasing environmental pollution due to an increasing global population. These changes have profound effects on human health and that of animals and the environment. How an alteration in humans, animals, or the environment causes a change in another is the focus of One Health and the topic of this Special Issue of Toxics.

We seek to publish original research papers, review articles, and short communications involving the One Health Triad. Studies utilizing epidemiological or experimental approaches on a local, national, or global scale are encouraged. Utilization of clinically relevant doses and routes of exposure to environmental pollutants is also encouraged in experimental studies. Most studies that utilize an experimental animal model of exposure to an environmental pollutant with known adverse health effects on humans incorporate all three aspects of the One Health Triad. However, in this Special Issue we will focus on examining how changes in one aspect of the One Health Triad affect the entire One Health Triad.

Prof. Dr. Joshua R. Edwards
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • One Health
  • environmental toxicology
  • animal models
  • environmental health
  • pollutants

Published Papers (1 paper)

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Research

Article
Zinc, Zinc Transporters, and Cadmium Cytotoxicity in a Cell Culture Model of Human Urothelium
Toxics 2021, 9(5), 94; https://doi.org/10.3390/toxics9050094 - 24 Apr 2021
Cited by 1 | Viewed by 881
Abstract
We explored the potential role of zinc (Zn) and zinc transporters in protection against cytotoxicity of cadmium (Cd) in a cell culture model of human urothelium, named UROtsa. We used real-time qRT-PCR to quantify transcript levels of 19 Zn transporters of the Zrt-/Irt-like [...] Read more.
We explored the potential role of zinc (Zn) and zinc transporters in protection against cytotoxicity of cadmium (Cd) in a cell culture model of human urothelium, named UROtsa. We used real-time qRT-PCR to quantify transcript levels of 19 Zn transporters of the Zrt-/Irt-like protein (ZIP) and ZnT gene families that were expressed in UROtsa cells and were altered by Cd exposure. Cd as low as 0.1 µM induced expression of ZnT1, known to mediate efflux of Zn and Cd. Loss of cell viability by 57% was seen 24 h after exposure to 2.5 µM Cd. Exposure to 2.5 µM Cd together with 10–50 µM Zn prevented loss of cell viability by 66%. Pretreatment of the UROtsa cells with an inhibitor of glutathione biosynthesis (buthionine sulfoximine) diminished ZnT1 induction by Cd with a resultant increase in sensitivity to Cd cytotoxicity. Conversely, pretreatment of UROtsa cells with an inhibitor of DNA methylation, 5-aza-2’-deoxycytidine (aza-dC) did not change the extent of ZnT1 induction by Cd. The induced expression of ZnT1 that remained impervious in cells treated with aza-dC coincided with resistance to Cd cytotoxicity. Therefore, expression of ZnT1 efflux transporter and Cd toxicity in UROtsa cells could be modulated, in part, by DNA methylation and glutathione biosynthesis. Induced expression of ZnT1 may be a viable mechanistic approach to mitigating cytotoxicity of Cd. Full article
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