Special Issue "Prenatal Exposures and Children’s Health"

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Environmental Epidemiology".

Deadline for manuscript submissions: 15 October 2021.

Special Issue Editors

Dr. Whitney Cowell
E-Mail
Guest Editor
Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Interests: prenatal environmental exposures; chemical/non-chemical stress interactions; placental signalling; endogenous biomarkers; fetal growth; pregnancy outcomes
Dr. Caitlin Howe
E-Mail Website
Guest Editor
Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA
Interests: environmental mixtures; metals; nutrition; early growth; cardiometabolic health; epigenetics; DOHaD

Special Issue Information

Dear Colleagues,

Fetal development follows a carefully orchestrated sequence of physiological shifts that promote dynamic growth and the establishment of key regulatory systems, among other critical processes. Many environmental chemicals can cross the placenta to directly disrupt this developmental cascade and alter the programming of physiological systems with enduring consequences. The developing fetus also has increased susceptibility to many environmental exposures, given its immature detoxification and other cellular defense pathways. In addition to direct fetal exposure, environmental chemicals may alter the maternal milieu or function of the placenta, which can have downstream consequences for prenatal development. Growing evidence also highlights the importance of considering the combined effect of multiple co-occurring exposures and the potential modifying roles of psychosocial stress and nutritional status.

This issue will explore a variety of topics related to prenatal environmental exposures and the developmental origins of health and disease, with a particular emphasis on the following areas: prenatal programming and the potential for adaptation, environmental or endogenous biomarkers of exposure or effect, impacts on the placenta and/or maternal system, environmental mixtures, and the modifying effects of nutrition and the social environment. Original research articles and reviews are welcome.

We look forward to receiving your contributions.

Dr. Whitney Cowell
Dr. Caitlin Howe
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • prenatal exposures
  • DOHaD
  • programming
  • child health
  • mixtures
  • environmental epidemiology
  • toxicology
  • nutrition

Published Papers (1 paper)

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Research

Article
Organophosphate Pesticide Exposures in Early and Late Pregnancy Influence Different Aspects of Infant Developmental Performance
Toxics 2021, 9(5), 99; https://doi.org/10.3390/toxics9050099 - 30 Apr 2021
Viewed by 560
Abstract
Organophosphate (OP) pesticides can transfer from mother to fetus via the placenta and amniotic fluid and may affect the development of infants. This study aims to evaluate the associations between maternal OP concentrations collected in the 1st–2nd trimester and the 3rd trimester of [...] Read more.
Organophosphate (OP) pesticides can transfer from mother to fetus via the placenta and amniotic fluid and may affect the development of infants. This study aims to evaluate the associations between maternal OP concentrations collected in the 1st–2nd trimester and the 3rd trimester of pregnancy and the infant developmental performance. The Screening Test of the Bayley Scales of Infants and Toddler Development, Third Edition (BSID–III screening test) was used to assess development performance at 2 and 6 months of age. Multiple regression analysis showed a negative correlation between cognitive performance at 2 months and maternal diethylthiophosphate (DETP) levels in the 1st–2nd trimester (β ± SE = −0.012 ± 0.004, p < 0.05). We also found that expressive communication and fine motor performance at 6 months were negatively associated with maternal diethyldithiophosphate (DEDTP) levels in the 3rd trimester (β ± SE = −0.047 ± 0.016, p < 0.05, and β ± SE = −0.044 ± 0.017, p < 0.05, respectively). These results suggest that maternal ethylated OP concentrations at different timing of exposure during pregnancy may influence different aspects of infant developmental performance. Full article
(This article belongs to the Special Issue Prenatal Exposures and Children’s Health)
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