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Separations, Volume 12, Issue 9

2025 September - 33 articles

Cover Story: Heliotropium procumbens, a Boraginaceae species native to Panama, remains understudied for nitrogen-containing metabolites, especially pyrrolizidine alkaloids (PAs). This study presents a detailed phytochemical analysis of its aerial parts using HPLC-DAD-IT-MS, UHPLC–HRMS, and GC-MS, identifying twelve PAs and their N-oxides, along with two phenolamides including N1, N10-diferuloylspermidine and the unique heliotropamide. The PAs included unsaturated necines, mainly retronecine and heliotridine monoesters, plus saturated platynecine-type and triol necines with N-oxides. Helifoline-N-oxide was isolated and structurally characterized by NMR for the first time. Comparison within the Heliotropium genus shows high PA diversity in H. procumbens, reflecting both its biosynthetic capacity and extensive study-enriching observed chemodiversity. View this paper
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Articles (33)

  • Review
  • Open Access
2,140 Views
24 Pages

22 September 2025

Wastewater analysis plays a central role in monitoring patterns of drug use within specific populations. It provides objective and real-time estimates of consumption, with minimal ethical concerns. In the current European context, drugs of abuse cont...

  • Article
  • Open Access
1 Citations
1,097 Views
15 Pages

21 September 2025

Tetrahydrofuran (THF) and methanol (MeOH) are widely used as organic solvents in chemical, pharmaceutical, and other industrial fields. The wastewater from producing 1,4-butanediol contains THF, MeOH, and water ternary azeotropic mixture. In this stu...

  • Article
  • Open Access
946 Views
26 Pages

Optimization of Organic Micropollutant Adsorption onto Granular Activated Carbon Using Response Surface Methodology

  • Nora Samghouli,
  • Najoua Labjar,
  • Meryem Bensemlali,
  • Hamid Nasrellah and
  • Souad El Hajjaji

21 September 2025

Water pollution from pharmaceutical and textile industries urgently requires effective treatment solutions due to environmental and health risks. Effective treatment methods are desperately needed for water pollution from the textile and pharmaceutic...

  • Article
  • Open Access
659 Views
26 Pages

Carp Scales Modified with Cerium Oxide Nanoparticles as a New Bio-Adsorbent for Arsenic and Chromium Separation from Water

  • Zoran Bajić,
  • Uroš Z. Veličković,
  • Veljko Djokić,
  • Mihael Bučko,
  • Jovica Bogdanov,
  • Krstimir Pantić and
  • Aleksandar D. Marinković

19 September 2025

Different treatments of fish scales from carps (Cyprinus carpio) (FS)—mechanical milling, modified with cerium dioxide (CeO2) nanoparticles and controlled carbonization of FS and modification with CeO2—were applied to obtain FS, FS-CeO2 a...

  • Article
  • Open Access
2 Citations
1,412 Views
20 Pages

Iron Recovery from Turkish and Romanian Bauxite Residues Through Magnetic Separation: Effect of Hydrothermal Processing and Separation Conditions

  • Panagiotis Angelopoulos,
  • Paschalis Oustadakis,
  • Nikolaos Kountouris,
  • Michail Samouhos,
  • Georgios Anastassakis and
  • Maria Taxiarchou

17 September 2025

This study investigates the potential of two low-iron-grade bauxite residue (BR) samples, containing up to 27.4 wt.% Fe and originating from alumina plants in Romania and Turkey, for the recovery of iron concentrate via wet magnetic separation. The m...

  • Article
  • Open Access
1 Citations
848 Views
12 Pages

Investigation on Li Recovery from Greek Coal Fly Ash Under a Circular Economy Framework: An Experimental Study

  • Despina Pentari,
  • Pagona Makri,
  • Panagiotis Xanthopoulos and
  • Despina Vamvuka

15 September 2025

Lithium is classified as a critical element and is widely used in a variety of high-tech applications. Within the framework of a circular economy, demand is rising for technologies capable of recovering high-tech metals from waste materials and indus...

  • Article
  • Open Access
1,710 Views
19 Pages

A Focus on the Emission of Volatile Organic Compounds (VOCs) from Raw Materials Potentially Used in Human Odor Sampling

  • Elsa Boudard,
  • Nabil Moumane,
  • José Dugay,
  • Jérôme Vial,
  • Michel Sablier and
  • Didier Thiébaut

11 September 2025

The present study provided an exhaustive examination of VOC emissions originating from 13 different raw materials susceptible to being used in the sampling of the human volatilome and encompassing both polymeric and non-polymeric compositions. To ach...

  • Article
  • Open Access
638 Views
19 Pages

Semi-Pilot Scale Extraction of Pinocembrin and Galangin from Populus alba L. × berolinensis K. Koch via Enzymatic Pretreatment and Ultrasonication

  • Ru Zhao,
  • Xiaoli Li,
  • Yazhou Bao,
  • Wenjun Xu,
  • Chen Xu,
  • Rongrong Wang,
  • Tianlan Xia,
  • Tingli Liu and
  • Ailing Ben

11 September 2025

In this investigation, pinocembrin and galangin were efficiently extracted from the male inflorescence of Populus alba L. × berolinensis K. Koch through an enzymatic pretreatment–ultrasonic-assisted strategy (EP-UAS), and the feasibility...

  • Article
  • Open Access
1 Citations
1,110 Views
21 Pages

Synthesis and CO2 Capture Properties of Co- and Nd-Modified ZIF-8 Materials Loaded onto Electrospun Polyacrylonitrile Fibers

  • Daniela Vargas-Romero,
  • Oscar Ovalle-Encinia,
  • Elizabeth Rojas-García,
  • Ana Marisela Maubert-Franco,
  • Mónica Corea,
  • Lucía Téllez-Jurado and
  • José Ortiz-Landeros

10 September 2025

Zeolitic imidazolate framework (ZIF)-8 materials exhibiting zinc metal centers partially replaced by cobalt or neodymium were successfully synthesized via a convenient coprecipitation method. The resulting materials were structurally and microstructu...

  • Article
  • Open Access
1 Citations
1,264 Views
22 Pages

Biosorption of Manganese Using Moringa oleifera Seed Pods: A Sustainable Approach to Water Treatment

  • Laura Adriane de Moraes Pinto,
  • Fernanda de Oliveira Tavares,
  • Rosangela Bergamasco,
  • Marcelo Fernandes Vieira and
  • Angélica Marquetotti Salcedo Vieira

9 September 2025

Manganese (Mn) has emerged as a contaminant of concern due to its occurrence at concentrations exceeding regulatory limits in various environmental matrices, driven by both anthropogenic activities and natural geochemical processes. Although Mn is an...

  • Article
  • Open Access
1 Citations
895 Views
14 Pages

9 September 2025

The photocatalytic reduction of hexavalent chromium (Cr(VI)) in wastewater represents a critical environmental challenge, given its high toxicity and mobility in wastewater. Conventional optimization methods relying on repetitive batch experiments wi...

  • Article
  • Open Access
4 Citations
1,059 Views
22 Pages

8 September 2025

Spiral concentrators are gravity and centrifugal force-based devices designed for mineral concentration. During processing operations, dynamic variations in the slurry’s liquid film thickness can induce hydrodynamic instability, generating roll...

  • Article
  • Open Access
2 Citations
1,203 Views
22 Pages

Box–Behnken-Assisted Optimization of High-Performance Liquid Chromatography Method for Enhanced Sugar Determination in Wild Sunflower Nectar

  • Nada Grahovac,
  • Milica Aleksić,
  • Lato Pezo,
  • Ana Đurović,
  • Zorica Stojanović,
  • Jelena Jocković and
  • Sandra Cvejić

7 September 2025

Sunflower (Helianthus annuus L.) is a cross-pollinated species that relies on pollinators, attracted by itsnectar composition. Nectar consists primarily of sugars (up to 70%), with sucrose, glucose, and fructose being dominant, while minor components...

  • Article
  • Open Access
1,122 Views
21 Pages

5 September 2025

The metabolism of antibiotics, antidepressants, and cardiovascular drugs has been investigated widely over the last few decades. The aim of this study was to develop an efficient analytical protocol based on the combination of electrochemistry (EC) a...

  • Article
  • Open Access
2 Citations
971 Views
12 Pages

5 September 2025

Tetracycline hydrochloride (TC-HCl) is widely used in the prevention and treatment of human/animal bacterial infection due to its good antibacterial activity. However, because of its high hydrophilicity and low volatility, TC-HCl can enter the natura...

  • Article
  • Open Access
881 Views
20 Pages

5 September 2025

Phenylalanine ammonia lyase (PAL) was first purified using affinity chromatography from the leaves of red-flowered clover, a highly antioxidant source. The characterization results of the PAL enzyme were determined, including the concentration of its...

  • Article
  • Open Access
2,142 Views
13 Pages

Simultaneous Determination of Polycyclic Aromatic Hydrocarbons and Anthraquinone in Yerba Mate by Modified MSPD Method and GC-MS

  • Dylan M. Hoffmann,
  • José D. da Silva,
  • Igor F. de Souza,
  • Gabriel A. B. Prates,
  • Vagner A. Dutra,
  • Osmar D. Prestes and
  • Renato Zanella

4 September 2025

Yerba mate (Ilex paraguariensis) is widely consumed in South America and is valued for its bioactive compounds, such as polyphenols and methylxanthines. However, during traditional processing, mainly in the fire-based scorch and drying steps, polycyc...

  • Article
  • Open Access
1,398 Views
18 Pages

Characterization of Pyrolysis Oils Using a Combination of GC×GC/TOFMS and GC/HRMS Analysis: The Impact of Data Processing Parameters

  • Xiangdong Chen,
  • Carlos Rincon,
  • Benoît Gadenne,
  • José Dugay,
  • Michel Sablier and
  • Jérôme Vial

4 September 2025

Human population growth and increasing transportation demands have led to rising global tire consumption and associated waste. In response, various material and energy recovery strategies, such as pyrolysis, have been developed to produce high-value-...

  • Review
  • Open Access
3 Citations
2,288 Views
23 Pages

4 September 2025

Polypeptides exhibit significant health-promoting effects through diverse biological activities, including antihypertensive, antidiabetic, anti-cancer, antimicrobial, and antioxidant properties. Membrane technology offers an efficient separation appr...

  • Review
  • Open Access
1 Citations
3,258 Views
24 Pages

Artificial Intelligence in Chemical Dosing for Wastewater Purification and Treatment: Current Trends and Future Perspectives

  • Jie Jin,
  • Ming Liu,
  • Boyu Chen,
  • Xuanbei Wu,
  • Ling Yao,
  • Yan Wang,
  • Xia Xiong,
  • Luoyu Wei,
  • Jiang Li and
  • Nuan Yang
  • + 4 authors

3 September 2025

Recent concerns regarding artificial intelligent (AI) technologies have spurred studies into improving wastewater treatment efficiency and identifying low-carbon processes. Treating one cubic meter of wastewater necessarily consumes a certain amount...

  • Review
  • Open Access
3 Citations
2,223 Views
17 Pages

Exploring the Influence of Extraction Methods, Solvents, and Temperature on Total Phenolic Recovery and Antioxidant Capacity in Olive Leaf Extracts: A Systematic Review with Quantitative Synthesis

  • María Castillo-Correa,
  • Cristina Montalbán-Hernández,
  • María D. Navarro-Hortal,
  • Diego Peña-Guzmán,
  • Alberto Badillo-Carrasco,
  • Alfonso Varela-López,
  • Daniel Hinojosa-Nogueira and
  • Jose M. Romero Márquez

3 September 2025

Background: Olive leaves are a rich source of bioactive phenolic compounds, but extraction yields vary depending on methodological choices. The aim was to identify optimal parameters for maximizing recovery and preserving antioxidant activity. Method...

  • Article
  • Open Access
4 Citations
1,264 Views
15 Pages

Ionic Speciation and Coordination Mechanisms of Vanadium, Iron, and Aluminum in the Oxalic Acid Leachate of Shale

  • Qing Xiong,
  • Zishuai Liu,
  • Qianwen Li,
  • Huiyang Lin,
  • Xuekun Tang and
  • Xianping Luo

1 September 2025

The oxalic acid leachate of vanadium-bearing shale (OALS) is a complex system in which the ion states and coordination mechanisms of the primary metallic elements—vanadium, iron, and aluminum—are not fully understood. This study investiga...

  • Article
  • Open Access
982 Views
16 Pages

Fly Ash-Derived Mesoporous Silica–Alumina Aerogel via an Optimized Water-Acid Leaching Process for Effective Methylene Blue Removal

  • Ke Sun,
  • Yike Liu,
  • Zhiming Zhang,
  • Jiayu Xu,
  • Jiajing Yu,
  • Jiankuan Zhang,
  • Lianzheng Gui,
  • Zhuo Chen and
  • Sha Liang

1 September 2025

Adsorption is a common method for solving the contamination of methylene blue (MB) in dyeing wastewater. Aerogel adsorbents with high porosity and specific surface areas have attracted increasing attention. However, the high costs of raw materials fo...

  • Article
  • Open Access
1 Citations
888 Views
29 Pages

1 September 2025

The synergistic effect of using D2EHPA and TOPO together to enhance the extraction of samarium(III) from aqueous media via emulsion liquid membrane (ELM) technology was explored. D2EHPA in binary mixtures with TBP and in ternary mixtures with TOPO an...

  • Article
  • Open Access
1,495 Views
15 Pages

Centrifugal Filtration Devices to Separate Peptides/Proteins as a Characterization Tool: Good Specificity but Poor Quantification

  • Marion Sicot,
  • Claire Gazaille,
  • Zeynep Güneş Tepe,
  • Léna Guyon,
  • Nolwenn Lautram,
  • Patrick Saulnier,
  • Joël Eyer,
  • Elise Lepeltier and
  • Guillaume Bastiat

Centrifugal filtration devices are increasingly being used to separate (bio)molecules thanks to their molar masses. This is partly due to their ease of use, with sample preparation requiring no complicated protocol and often being able to be run as i...

  • Article
  • Open Access
774 Views
17 Pages

The current research aims to develop a simple, sensitive, and green analytical method for the group extraction/monitoring of 19 organochlorine and organophosphorus pesticides from fruit juices using microwave radiation to assist a cloud point extract...

  • Review
  • Open Access
1,509 Views
22 Pages

With the continuous expansion of rare earth resource development, the large-scale accumulation of ionic rare earth tailings (IRETs) has exerted pressure on both environmental and resource management. Due to their inherent low reactivity, unstable com...

  • Article
  • Open Access
2 Citations
947 Views
14 Pages

Synergistic Enhancement of Sludge Deep Dewatering via Tea Waste and Sludge-Derived Biochars Coupled with Polyaluminum Chloride

  • Qiang-Ying Zhang,
  • Geng Xu,
  • Hui-Yun Qi,
  • Xuan-Xin Chen,
  • Hou-Feng Wang and
  • Xiao-Mei Cui

Although coagulation can enhance sludge dewatering performance, it often leads to dense flocs, hindered water release, and secondary pollution of the sludge cake. In this study, three types of biochar-based skeleton materials, tea waste-derived bioch...

  • Article
  • Open Access
3 Citations
753 Views
24 Pages

This study reports an investigation of the synergistic extraction of dysprosium (Dy(III)) from aqueous media using a low-concentration, binary carrier mixture of Cyanex 272 and D2EHPA within an emulsion liquid membrane (ELM). Within the tested formul...

  • Article
  • Open Access
941 Views
11 Pages

Highly Efficient Extraction of Phenolic Compounds from Coal Tar Using Alcohol Amine Aqueous Solutions via Synergistic Extraction

  • Yonglin Li,
  • Bing Peng,
  • Yeping Yang,
  • Qiuhong Ai,
  • Jiayi Zhou,
  • Yong Wang,
  • Huajie Liu and
  • Weiwei Yan

This study utilizes aqueous solutions of organic amines as extractants to remove phenolic compounds from coal tar. It elucidates the extraction mechanism between phenolic compounds and organic amines, and conducts a comprehensive investigation into t...

  • Article
  • Open Access
1 Citations
1,015 Views
21 Pages

Alkali-Resistant Ion-Imprinted Chitosan–Mesoporous Silica Composite for Efficient and Selective Gallium Separation

  • Zhifang Lv,
  • Shiqiao Yang,
  • Jiangyan Wu,
  • Guixia Fan,
  • Guosheng Li,
  • Yijun Cao,
  • Peng Li and
  • Daoguang Teng

Efficient and selective separation of gallium (Ga(III)) from alkaline industrial waste streams remains a significant challenge due to the coexistence of chemically similar ions such as Al(III) and V(V). In this study, a novel ion-imprinted chitosan-b...

  • Article
  • Open Access
1,258 Views
16 Pages

Chemistry and Diversity of Nitrogen-Containing Metabolites in Heliotropium procumbens: A Genus-Wide Comparative Profile

  • Kalliopi-Maria Ozntamar-Pouloglou,
  • Evgenia Panou,
  • Tomasz Mroczek,
  • Nikola Milic,
  • Konstantia Graikou,
  • Christos Ganos,
  • Nikolas Fokialakis,
  • George-Albert Karikas and
  • Ioanna Chinou

Heliotropium procumbens, a Boraginaceae species native to Panama, has remained largely unexplored regarding its nitrogen-containing metabolites, including pyrrolizidine alkaloids (PAs). In the current study, a comprehensive phytochemical investigatio...

  • Article
  • Open Access
2 Citations
2,373 Views
15 Pages

Desalination plays a critical role in addressing global water scarcity, yet brine disposal remains a significant environmental challenge. This study evaluates a minimal liquid discharge (MLD) membrane-based system integrating high-pressure reverse os...

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Separations - ISSN 2297-8739