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Processes, Volume 6, Issue 10

2018 October - 32 articles

Cover Story: Model-based design tools have been widely applied to improve the performance of (bio)chemical and pharmaceutical processes. However, the reliability of these designs is subject to model uncertainties, i.e., epistemic deficiencies or intrinsic randomness. Neglecting model uncertainties might lead to suboptimal process designs or even malfunctions. In this work, we propose a comprehensive and efficient robust process design approach including (1) parameter uncertainties and correlations, (2) parameter sensitivity analysis, and (3) and the formulation of robust inequality and equality constraints. In simulation studies, we demonstrate the robustification strategy successfully on the design of (bio)chemical and pharmaceutical processes. View this paper.
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Articles (32)

  • Article
  • Open Access
19 Citations
7,130 Views
21 Pages

Geotechnical Properties of Effluent-Contaminated Cohesive Soils and Their Stabilization Using Industrial By-Products

  • Muhammad Irfan,
  • Yulong Chen,
  • Muhammad Ali,
  • Muhammad Abrar,
  • Ahmed Qadri and
  • Osama Bhutta

22 October 2018

The unchecked and unnoticed disposal of industrial leachates is a common malpractice in developing countries. Untreated effluents from industries drastically deteriorate the soil, altering nearly all of its characteristics. An increase in urbanizatio...

  • Feature Paper
  • Article
  • Open Access
10 Citations
4,396 Views
17 Pages

22 October 2018

In the context of an increasing participation of renewable energy in the electricity market, demand response is a strategy promoted by electricity companies to balance the non-programmable supply of electricity with its usage. Through the use of diff...

  • Article
  • Open Access
9 Citations
3,722 Views
18 Pages

Changes in Particle Size Composition under Seepage Conditions of Reclaimed Soil in Xinjiang, China

  • Zizhao Zhang,
  • Wanghua Sui,
  • Kaikai Wang,
  • Guobin Tang and
  • Xiaoping Li

20 October 2018

The distribution of reclaimed soil particle size under seepage conditions after the management period will directly determine the success or failure of reclamation work. The geotechnical experimental method was used in this paper to study the changes...

  • Article
  • Open Access
8 Citations
3,626 Views
19 Pages

20 October 2018

With the rapid growth of energy consumption, how to utilize energy in an efficient and cheap way becomes an intensive problem. This paper proposes an optimal operation strategy to reduce system fuel costs and increase system stability by independentl...

  • Article
  • Open Access
53 Citations
8,255 Views
15 Pages

19 October 2018

Taking Nanfen open-pit iron mine in Liaoning Province as the engineering background, this study analyzes the effect of water-rock circulation on the mechanical properties of rock through a combination of macro-mechanical experiments and microstructur...

  • Article
  • Open Access
10 Citations
8,349 Views
35 Pages

19 October 2018

For the requirements of performance assessment of the thermal power plant control process, the combustion control system of a 330 MW generator unit in a power plant is studied. Firstly, the five variables that affect the process control performance a...

  • Feature Paper
  • Article
  • Open Access
28 Citations
8,398 Views
13 Pages

Mathematical Modelling and Simulation of a Spray Fluidized Bed Granulator

  • Gurmeet Kaur,
  • Mehakpreet Singh,
  • Jitendra Kumar,
  • Thomas De Beer and
  • Ingmar Nopens

18 October 2018

In this present work, a study of the modelling and simulation for a top-sprayed fluidized bed granulator (SFBG) is presented, which is substantially used by the pharmaceutical industry to prepare granules. The idea is to build a number-based mathemat...

  • Article
  • Open Access
2 Citations
4,212 Views
15 Pages

18 October 2018

In situ gasification chemical looping combustion (iG-CLC) is a novel and promising coal combustion technology with inherent separation of CO2. Our previous studies demonstrated the feasibility of performing iG-CLC with a high-flux circulating fluidiz...

  • Article
  • Open Access
18 Citations
5,224 Views
20 Pages

Interactive Tool for Frequency Domain Tuning of PID Controllers

  • Juan Garrido,
  • Mario L. Ruz,
  • Fernando Morilla and
  • Francisco Vázquez

18 October 2018

This paper presents an interactive tool focused on the study of proportional-integral-derivative (PID) controllers. Nowadays, PID control loops are extensively used in industrial applications. However, it is reported that many of them are badly tuned...

  • Feature Paper
  • Article
  • Open Access
17 Citations
5,119 Views
31 Pages

18 October 2018

The compressor fuel cost minimization problem (FCMP) for natural gas pipelines is a relevant problem because of the substantial energy consumption of compressor stations transporting the large global demand for natural gas. The common method for mode...

  • Feature Paper
  • Article
  • Open Access
11 Citations
7,996 Views
16 Pages

Simulation of Dual Mixed Refrigerant Natural Gas Liquefaction Processes Using a Nonsmooth Framework

  • Matias Vikse,
  • Harry A. J. Watson,
  • Truls Gundersen and
  • Paul I. Barton

17 October 2018

Natural gas liquefaction is an energy intensive process where the feed is cooled from ambient temperature down to cryogenic temperatures. Different liquefaction cycles exist depending on the application, with dual mixed refrigerant processes normally...

  • Article
  • Open Access
13 Citations
5,244 Views
13 Pages

17 October 2018

This study investigates the effect of carbon nanotube (CNT) dispersion on the mechanical properties and microstructures of ultra-light foamed concrete. A type of uniform and stable CNT dispersion solution is obtained by adding nano-Ce(SO4)2. Results...

  • Article
  • Open Access
25 Citations
4,122 Views
16 Pages

Experimental Investigation on the Law of Grout Diffusion in Fractured Porous Rock Mass and Its Application

  • Donghai Jiang,
  • Xianzhen Cheng,
  • Hengjie Luan,
  • Tongxu Wang,
  • Mingguang Zhang and
  • Ruiyun Hao

16 October 2018

Because of the limitation of mining techniques and economic conditions, large amounts of residual coal resources have been left in underground coal mines around the world. Currently, with mining technology gradually developing, residual coal can poss...

  • Article
  • Open Access
11 Citations
3,784 Views
16 Pages

Rheological Behavior and Modeling of a Crushed Sandstone-Mudstone Particle Mixture

  • Zhenfeng Qiu,
  • Ting Cao,
  • Yongsuo Li,
  • Junjie Wang and
  • Yulong Chen

16 October 2018

A mixture of sandstone and mudstone particles is often used as the main filling material for many agriculture-related and civil engineering projects, including rock-fill dams and foundations. The long-term rheological deformation experienced by rock-...

  • Article
  • Open Access
34 Citations
4,317 Views
20 Pages

15 October 2018

The mechanical properties and seepage characteristics of gas-bearing coal evolve with changes in the loading pattern, which could reveal the evolution of permeability in a protected coal seam and allow gas extraction engineering work to be designed b...

  • Article
  • Open Access
15 Citations
6,656 Views
18 Pages

12 October 2018

The aim of this study was to microencapsulate an optimized extract of purple cactus pear fruit (Opuntia ficus indica), rich in phenolic compounds (PC), betacyanins (BC), and betaxanthins (BX), with antioxidant capacity (AC), by two methodologies: com...

  • Article
  • Open Access
28 Citations
10,305 Views
17 Pages

Non-Viral Transfection of Human T Lymphocytes

  • Simon A. B. Riedl,
  • Patrick Kaiser,
  • Alexander Raup,
  • Christopher V. Synatschke,
  • Valérie Jérôme and
  • Ruth Freitag

11 October 2018

The genetic modification of human T lymphocytes with established non-viral methods is inefficient. Linear polyethylenimine (l-PEI), one of the most popular non-viral transfection agents for mammalian cells in general, only achieves transfection rates...

  • Feature Paper
  • Article
  • Open Access
5 Citations
3,919 Views
16 Pages

10 October 2018

Multicellular systems play an important role in many biotechnological processes. Typically, these exhibit cell-to-cell variability, which has to be monitored closely for process control and optimization. However, some properties may not be measurable...

  • Article
  • Open Access
6 Citations
4,349 Views
13 Pages

Experimental Investigation of the Decarburization Behavior of Medical Waste Incinerator Fly Ash (MWIFA)

  • Guoxia Wei,
  • Hanqiao Liu,
  • Fang Liu,
  • Tongtong Zeng,
  • Guisheng Liu and
  • Jianhua Zhou

8 October 2018

The objective of the research was to compare the flotation performance of medical waste incinerator fly ash (MWIFA) by considering two methods: the cyclonic-static micro-bubble flotation column (FCSMC) method and conventional flotation cell (CFC) met...

  • Feature Paper
  • Article
  • Open Access
10 Citations
5,402 Views
22 Pages

Modeling the Separation of Microorganisms in Bioprocesses by Flotation

  • Stefan Schmideder,
  • Christoph Kirse,
  • Julia Hofinger,
  • Sascha Rollié and
  • Heiko Briesen

6 October 2018

Bioprocesses for the production of renewable energies and materials lack efficient separation processes for the utilized microorganisms such as algae and yeasts. Dissolved air flotation (DAF) and microflotation are promising approaches to overcome th...

  • Article
  • Open Access
10 Citations
6,488 Views
18 Pages

Numerical Simulation of a New Porous Medium Burner with Two Sections and Double Decks

  • Zhenzhen Jia,
  • Qing Ye,
  • Haizhen Wang,
  • He Li and
  • Shiliang Shi

6 October 2018

Porous medium burners are characterized by high efficiency and good stability. In this study, a new burner was proposed based on the combustion mechanism of the methane-air mixture in the porous medium and the preheating effect. The new burner is a t...

  • Feature Paper
  • Article
  • Open Access
11 Citations
5,369 Views
26 Pages

3 October 2018

Model-based design principles have received considerable attention in biotechnology and the chemical industry over the last two decades. However, parameter uncertainties of first-principle models are critical in model-based design and have led to the...

  • Article
  • Open Access
10 Citations
6,348 Views
21 Pages

2 October 2018

Liquid-liquid extraction (LLE) is an established unit operation in the manufacturing process of many products. However, development and integration of multistage LLE for new products and separation routes is often hindered and is probably more cost i...

  • Article
  • Open Access
14 Citations
6,585 Views
18 Pages

2 October 2018

In this study, the purification of an extract from Artemisia annua L. using chromatographic methods is studied. In a first step, a screening of different phases and solvents using thin-layer chromatography (TLC) was performed. Then, a laboratory-scal...

  • Article
  • Open Access
17 Citations
5,259 Views
16 Pages

2 October 2018

In this study, process integration for crystallization of a priori purified Artemisia annua L. is investigated. For this total process, the integration operation boundaries and behavior of the crystals are studied. This is performed focusing on a con...

  • Article
  • Open Access
2 Citations
3,996 Views
12 Pages

2 October 2018

No unified electromagnetic anti-fouling mechanism is currently available. Most research has focused on the effects of structural parameters and water quality parameters on electromagnetic fields; variations in water quality parameters under the influ...

  • Article
  • Open Access
7 Citations
5,621 Views
9 Pages

1 October 2018

Phragmites australis straw (PAS) is an abundant and renewable wetland lignocellulose. Bacillus coagulans IPE22 is a robust thermophilic strain with pentose-utilizing capability and excellent resistance to growth inhibitors. This work is focused on th...

  • Feature Paper
  • Article
  • Open Access
18 Citations
6,949 Views
15 Pages

Glycosylation Flux Analysis of Immunoglobulin G in Chinese Hamster Ovary Perfusion Cell Culture

  • Sandro Hutter,
  • Moritz Wolf,
  • Nan Papili Gao,
  • Dario Lepori,
  • Thea Schweigler,
  • Massimo Morbidelli and
  • Rudiyanto Gunawan

1 October 2018

The terminal sugar molecules of the N-linked glycan attached to the fragment crystalizable (Fc) region is a critical quality attribute of therapeutic monoclonal antibodies (mAbs) such as immunoglobulin G (IgG). There exists naturally-occurring hetero...

  • Perspective
  • Open Access
31 Citations
11,148 Views
28 Pages

Natural Products Extraction of the Future—Sustainable Manufacturing Solutions for Societal Needs

  • Lukas Uhlenbrock,
  • Maximilian Sixt,
  • Martin Tegtmeier,
  • Hartwig Schulz,
  • Hansjörg Hagels,
  • Reinhard Ditz and
  • Jochen Strube

1 October 2018

The production of plant-based extracts is significantly influenced by traditional techniques and the natural variability of feedstock. For that reason, the discussion of innovative approaches to improve the manufacturing of established products and t...

  • Article
  • Open Access
13 Citations
4,278 Views
14 Pages

The Influence of O2 on Decomposition Characteristics of c-C4F8/N2 Environmental Friendly Insulating Gas

  • Song Xiao,
  • Shuangshuang Tian,
  • Xiaoxing Zhang,
  • Yann Cressault,
  • Ju Tang,
  • Zaitao Deng and
  • Yi Li

29 September 2018

The c-C4F8 gas is considered to have great potential as a gaseous medium for gas-insulated equipment, due to its good insulation properties and its relatively low greenhouse gas potential (GWP) relative to SF6. However, the decomposition is an import...

  • Review
  • Open Access
56 Citations
9,044 Views
25 Pages

Characteristics and Treatment Methods of Medical Waste Incinerator Fly Ash: A Review

  • Fang Liu,
  • Han-Qiao Liu,
  • Guo-Xia Wei,
  • Rui Zhang,
  • Tong-Tong Zeng,
  • Gui-Sheng Liu and
  • Jian-Hua Zhou

26 September 2018

Medical waste incinerator fly ash (MWIFA) is quite different from municipal solid waste incinerator fly ash (MSWIFA) due to its special characteristics of high levels of chlorines, dioxins, carbon constituents, and heavy metals, which may cause irrev...

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Processes - ISSN 2227-9717