Children, Volume 11, Issue 1
2024 January - 137 articles
Cover Story: The potential of sonothrombolysis as a noninvasive pediatric therapy for thrombotic disease remains untapped, warranting urgent research to investigate its safety and efficacy in children. This timely review explores the state of the art of this emerging clot-busting technique utilizing ultrasound waves, microbubbles, and thrombolytic agents. While numerous preclinical animal and human studies demonstrate success in treating adults, quantified data on pediatric sonothrombolysis applications is lacking. The authors review known protocols, parameters, and study outcomes, highlighting promising results and knowledge gaps inhibiting clinical implementation in young patients. This paper emphasizes further research on mapping sonothrombolysis’ future pediatric landscape to realize this technology’s clinical promise in a way that is both ethical and safe for children. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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