Pharmacy

20 pages, 339 KB

Open AccessReview

Intrathecal Drug Delivery Systems for Chronic Pain Management: A Narrative Review of Pharmacologic Agents, Clinical Applications, and Considerations

by Milan Patel, Alison J. Deng, Madelyn Reilly, Mariam Morcus, Alyssa McKenzie, Lukas Henjum, Alan D. Kaye and Alaa Abd-Elsayed

Pharmacy 2025, 13(6), 185; https://doi.org/10.3390/pharmacy13060185 - 16 Dec 2025

Viewed by 2599

Abstract

This narrative review seeks to delve into the different on and off-label medications commonly used with intrathecal drug delivery systems (IDDS) and their clinical applications specifically in pain management settings. This review utilizes a variety of studies including reviews, retrospective chart analyses, and [...] Read more.

This narrative review seeks to delve into the different on and off-label medications commonly used with intrathecal drug delivery systems (IDDS) and their clinical applications specifically in pain management settings. This review utilizes a variety of studies including reviews, retrospective chart analyses, and more to analyze the current effectiveness of various pharmacological agents on reducing chronic pain through IDDS. The initial results of intrathecal delivery of these medications have provided benefit in pain reduction and overall patient satisfaction; however, this review will seek to analyze the current data and understanding and suggest areas of strength and improvement within the field and our current understanding. Full article

13 pages, 341 KB

Open AccessArticle

Prevalence of Potentially Inappropriate Medications in Drug Dispensing Data of Older Adults Living in Northwest Italy

by Lucrezia Greta Armando, Jacopo Luboz, Abdoulaye Diarassouba, Gianluca Miglio and Clara Cena

Pharmacy 2025, 13(6), 184; https://doi.org/10.3390/pharmacy13060184 - 15 Dec 2025

Viewed by 785

Abstract

The increasing use of multiple medications among older adults raises concerns about potentially inappropriate medications (PIMs), which are associated with adverse health outcomes and increased healthcare costs. This study aimed to assess the prevalence and types of PIMs dispensed to older adults living [...] Read more.

The increasing use of multiple medications among older adults raises concerns about potentially inappropriate medications (PIMs), which are associated with adverse health outcomes and increased healthcare costs. This study aimed to assess the prevalence and types of PIMs dispensed to older adults living in Northwest Italy using real-world pharmacy claims data. An observational, retrospective analysis was conducted on anonymized drug dispensing datasets from two local health authorities, covering individuals aged 65 years or older between 2018 and 2021. PIMs were identified according to the 2019 American Geriatrics Society Beers Criteria, focusing on drugs that are inappropriate or should be used with caution in older adults or have anticholinergic properties. Over half of older adults who received medications during the study period were dispensed at least one PIM, with stable or slight increased prevalence over time with no differences by sex or region. Proton-pump inhibitors used for more than 8 weeks and paroxetine were the most common PIMs, while furosemide and sulfonylureas were also frequently reported PIMs. These findings indicate a persistently high burden of inappropriate prescribing in older adults and highlight the need for coordinated deprescribing interventions and prescriber education to promote safer, evidence-based pharmacotherapy in aging populations. Full article

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9 pages, 188 KB

Open AccessBrief Report

Pharmacy Students’ Perspectives on Integrating Generative AI into Pharmacy Education

by Kaitlin M. Alexander, Eli O. Jorgensen, Casey Rowe and Khoa Nguyen

Pharmacy 2025, 13(6), 183; https://doi.org/10.3390/pharmacy13060183 - 15 Dec 2025

Viewed by 1078

Abstract

Objective: This study aims to evaluate pharmacy students’ perceptions regarding the integration of generative artificial intelligence (GenAI) into pharmacy curricula, providing evidence to inform future curriculum development. Methods: A cross-sectional survey of Doctor of Pharmacy (PharmD) students at a single U.S. College of [...] Read more.

Objective: This study aims to evaluate pharmacy students’ perceptions regarding the integration of generative artificial intelligence (GenAI) into pharmacy curricula, providing evidence to inform future curriculum development. Methods: A cross-sectional survey of Doctor of Pharmacy (PharmD) students at a single U.S. College of Pharmacy was conducted in April 2025. Students from all four professional years (P1–P4) were invited to participate. The 10-item survey assessed four domains: (1) General GenAI Use, (2) Knowledge and Experience with GenAI Tools, (3) Learning Preferences with GenAI, and (4) Perspectives on GenAI in the curriculum. Results: A total of 110 students responded (response rate = 12.4%). Most were P1 students (56/110, 50.9%). Many reported using GenAI tools for personal (65/110, 59.1%) and school-related purposes (64/110, 58.1%) sometimes, often, or frequently. ChatGPT was the most used tool. While 40% (40/99) agreed or strongly agreed that GenAI could enhance their learning, 62.6% (62/99) preferred traditional teaching methods. Open-ended responses (n = 25) reflected a mix of positive, neutral, and negative views on GenAI in education. Conclusions: Many pharmacy students in this cohort reported using GenAI tools and demonstrated a basic understanding of GenAI functions, yet students also reported that they preferred traditional learning methods and expressed mixed views on incorporating GenAI into teaching. These findings provide valuable insights for faculty and schools of pharmacy as they develop strategies to integrate GenAI into pharmacy education. Full article

(This article belongs to the Special Issue AI Use in Pharmacy and Pharmacy Education)

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13 pages, 1976 KB

Open AccessArticle

Impacts of Outsourcing Medication Repackaging in Nursing Homes: Quality and Areas of Pharmacy–Nursing Collaboration

by Thomas Schmid, Falk Hoffmann, Michael Dörks and Kathrin Jobski

Pharmacy 2025, 13(6), 182; https://doi.org/10.3390/pharmacy13060182 - 13 Dec 2025

Viewed by 611

Abstract

The task of repackaging resident’s medication into medication organizers is increasingly outsourced from nursing homes to pharmacies, presenting an opportunity to redefine the interaction between nursing and pharmaceutical staff. This study investigated whether outsourcing medication repackaging changes the quality and subjects of collaboration [...] Read more.

The task of repackaging resident’s medication into medication organizers is increasingly outsourced from nursing homes to pharmacies, presenting an opportunity to redefine the interaction between nursing and pharmaceutical staff. This study investigated whether outsourcing medication repackaging changes the quality and subjects of collaboration between the two professions. A cross-sectional survey was developed targeting heads of nursing in German nursing homes. A simple random sample of 1415 nursing homes was contacted by phone. Respondents participated either by phone or by online survey. Quality of collaboration was measured using Kenaszchuk’s Interprofessional Collaboration Scale (ICS) with its subscales Communication, Accommodation and Isolation. Topics of interaction were ascertained using items along a medication management phase model. Differences in response frequencies were analyzed using Fisher’s exact test. A total of 268 nursing homes participated (response: 18.9%). Of these, 132 (49.3%) had outsourced repackaging. Respondents at nursing homes with in-house medication repackaging rated the subscale Accommodation more favorably (p = 0.008), while Communication and Isolation showed no difference. Of the 13 individual ICS items, “passing on information” (Communication) was rated better by respondents at homes with outsourced repackaging (p = 0.019) and “consideration of convenience” (Accommodation) more favorably by respondents at homes with in-house repackaging (p = 0.042). Nursing staff at homes with outsourced medication repackaging interacted with pharmaceutical staff more frequently on medication changes (p < 0.001), but less frequently on tablet splitting (p = 0.035). In conclusion, outsourcing medication repackaging has a limited impact on the quality of interprofessional collaboration between the two professions but may have the potential to reduce ambiguities regarding splitting tablets. Full article

(This article belongs to the Section Pharmacy Practice and Practice-Based Research)

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13 pages, 937 KB

Open AccessArticle

Benzodiazepine (BZD) Use and Patient Safety: Opportunities for Community Pharmacy Involvement in the Management of Drug Interactions

by Juan Ramón Santana Ayala, Daida Alberto Armas, Veronica Hernández García, Armando Aguirre-Jaime, Ángel J. Gutiérrez, Soraya Paz-Montelongo, Arturo Hardisson de la Torre and Carmen Rubio Armendáriz

Pharmacy 2025, 13(6), 181; https://doi.org/10.3390/pharmacy13060181 - 11 Dec 2025

Viewed by 1846

Abstract

Introduction: During pharmaceutical care, community pharmacists play a crucial role by carrying out interventions aimed at preventing, detecting, and resolving drug-related problems (DRPs) and negative outcomes associated with medication (NOM), simultaneously enhancing patients’ knowledge about their treatments. The chronic use of Benzodiazepines (BZDs) [...] Read more.

Introduction: During pharmaceutical care, community pharmacists play a crucial role by carrying out interventions aimed at preventing, detecting, and resolving drug-related problems (DRPs) and negative outcomes associated with medication (NOM), simultaneously enhancing patients’ knowledge about their treatments. The chronic use of Benzodiazepines (BZDs) is known to be associated with risks such as tolerance, dependence, and cognitive impairment. Furthermore, the combined use of BZDs with other medications or alcohol may expose patients to significant drug interactions. Objectives: This study aimed to characterize and describe the clinical profile of patients using BZDs, to evaluate the extent of polypharmacy and potential drug interactions, to investigate their level of knowledge regarding BZD treatment, and ultimately, to propose evidence-based interventions from the community pharmacy to contribute to improving patient safety and minimizing risks associated with BZD use. Method: A cross-sectional, descriptive study was conducted in a single community pharmacy in Gran Canaria (Canary Islands, Spain). The study population comprised 125 adult patients with active BZD prescriptions. Data collection was performed through pharmacist–patient structured interviews using a questionnaire that included sociodemographic, clinical, and BZD knowledge variables. Results: Lormetazepam and alprazolam were the BZDs most frequently prescribed and dispensed. Potential drug interactions with other medications were detected in 38.4% of BZD users. Notably, 61.5% of patients using BZDs also reported the concurrent use of opioid analgesics, with tramadol being the most common opioid (48.1% of BZD users were also treated with tramadol). Statistically significant differences were observed between patients with and without BZD and other drug interactions in several adverse outcome variables, including the risk of falls (p = 0.003), cognitive impairment (p = 0.047), and urinary incontinence (p = 0.016). Existing BZD dependence is detected in 25% and 22.1% of cases, respectively. Patients’ knowledge of their BZD treatment revealed critical gaps, which are identified as a challenge and a clear opportunity for intervention through pharmaceutical care services. Conclusions: The findings underscore the essential and proactive role of community pharmacists in identifying and managing drug interactions, as well as in supporting deprescribing strategies through collaborative and interprofessional care models. Full article

(This article belongs to the Section Pharmacy Practice and Practice-Based Research)

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23 pages, 564 KB

Open AccessPerspective

Advances in Drug and Vaccine Delivery for Low- and Middle-Income Healthcare Programs—The Case for Replacing Multi-Dose Vials with Prefilled Single-Dose Delivery Systems

by Darin Zehrung and Michael J. Free

Pharmacy 2025, 13(6), 180; https://doi.org/10.3390/pharmacy13060180 - 10 Dec 2025

Viewed by 2081

Abstract

The transition toward wide-scale use of single-dose administration systems such as prefilled syringes has primarily occurred in high-income countries due to economic considerations. This has resulted in a disparity of access to such technologies in low- and middle-income countries, which continue to utilize [...] Read more.

The transition toward wide-scale use of single-dose administration systems such as prefilled syringes has primarily occurred in high-income countries due to economic considerations. This has resulted in a disparity of access to such technologies in low- and middle-income countries, which continue to utilize multi-dose vial-based presentations and syringes for parenteral delivery. Single-dose innovations currently available or in the product development pipeline represent the promise of enhanced access globally and the potential for public health impact. This perspective article discusses the reported benefits of pre-filled single-dose delivery systems compared to multi-dose vials, as well as the higher standards of infection control regulations and practices that resulted in the increasing use of and benefit from single-dose administration systems in high-income countries. We evaluated how these benefits and standards could enhance health initiatives in low- and middle-income countries. Finally, we explored the potential for making pre-filled single-dose delivery methods both accessible and affordable in low- and middle-income countries. Full article

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15 pages, 919 KB

Open AccessArticle

Drug Repurposing for Inclusion of COVID-19-Related Indication: Field Study of the European Medicines Agency’s Response to the Pandemic

by Antonio Ivanov, Violeta Getova-Kolarova and Ines Hababa-Ivanova

Pharmacy 2025, 13(6), 179; https://doi.org/10.3390/pharmacy13060179 - 10 Dec 2025

Viewed by 684

Abstract

As one of the biggest challenges for healthcare in the 21st century, COVID-19 placed a sustained and intense demand on the European Medicines Agency’s resources and required constant adaptation and mobilization of different regulatory processes. In this situation, drug repurposing appeared as a [...] Read more.

As one of the biggest challenges for healthcare in the 21st century, COVID-19 placed a sustained and intense demand on the European Medicines Agency’s resources and required constant adaptation and mobilization of different regulatory processes. In this situation, drug repurposing appeared as a promising potential approach in quickly emerging health crises due to its main advantage of reducing the time and cost for addition of new indications since it uses products proven to be of high quality, safe, and effective. We performed an analysis of European Public Assessment Reports for medicinal products authorized for the SARS-CoV-2 infection by the European Medicines Agency, showing a total of eight products with this indication, three (37.5%) of which used repurposing as a mechanism for development (remdesivir, tocilizumab, and anakinra). The application of this mechanism by these medicines highlights the importance of the life cycle stage at which repositioning is undertaken, which resulted in different volumes of data submitted in the respective European Public Assessment Reports. The participation of organizations other than the marketing authorization holder in key stages in the drug development process of repurposed products was once again confirmed, which emphasizes the need to regulate this interaction. Full article

(This article belongs to the Special Issue Drug Repurposing: Strengthening Outcomes of Existing Pharmaceuticals to Shift Emerging Health Challenges)

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11 pages, 520 KB

Open AccessArticle

Mining of Adverse Event Signals Associated with Fluticasone Furoate/Umeclidinium/Vilanterol Triple Therapy: A Post-Marketing Analysis Based on FAERS

by Jiajun Chen, Ying Qiao, Gaoxing Qiao, Xiaocan Jia and Jicun Zhu

Pharmacy 2025, 13(6), 178; https://doi.org/10.3390/pharmacy13060178 - 10 Dec 2025

Viewed by 893

Abstract

Chronic obstructive pulmonary disease (COPD) is a major global health burden. The fluticasone furoate (FF)/umeclidinium (UMEC)/vilanterol (VI) triple therapy provides new treatment, but its long-term real-world safety lacks evidence. A post-marketing analysis used the FAERS database to identify adverse event (AE) signals for [...] Read more.

Chronic obstructive pulmonary disease (COPD) is a major global health burden. The fluticasone furoate (FF)/umeclidinium (UMEC)/vilanterol (VI) triple therapy provides new treatment, but its long-term real-world safety lacks evidence. A post-marketing analysis used the FAERS database to identify adverse event (AE) signals for FF/UMEC/VI. Disproportionality methods including reporting odds ratio (ROR), proportional reporting ratio (PRR), information component (IC), and empirical Bayesian geometric mean (EBGM), were applied to detect AE signals, focusing on reports from third quarter (Q3) 2019 to Q3 2024. Among 16,238 reports listing FF/UMEC/VI as primary suspect, significant AE signals occurred in ‘injury, poisoning and procedural complications’ (n = 9067, ROR 2.46, PRR 2.08, IC 1.06, EBGM 2.08), and ‘respiratory, thoracic and mediastinal disorders’ (n = 6567, ROR 4.87, PRR 4.15, IC 2.05, EBGM 4.13). A total of 196 significantly disproportionate preferred terms (PTs) were identified, including previously undocumented AEs such as chronic eosinophilic rhinosinusitis, dysphonia, and vocal cord dysfunction. This post-marketing safety study revealed significant signals for dysphonia and vocal cord dysfunction associated with FF/UMEC/VI, suggesting that clinicians should remain vigilant for these events. Full article

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14 pages, 1097 KB

Open AccessArticle

Telepharmacy Consultations (TPCs) in Local Pharmacies—A Bi-Centric Survey of Customer Opinions

by Nathalie Floch, Philipp Harand, Chris Graichen and Thilo Bertsche

Pharmacy 2025, 13(6), 177; https://doi.org/10.3390/pharmacy13060177 - 8 Dec 2025

Viewed by 995

Abstract

Background: Telepharmacy consultations (TPCs) became a routine element of pharmacy operations. However, there is limited data available on local pharmacy customer feedback related to TPC. Methods: A customer survey was developed seeking feedback on TPC. The pharmacy customers were invited to [...] Read more.

Background: Telepharmacy consultations (TPCs) became a routine element of pharmacy operations. However, there is limited data available on local pharmacy customer feedback related to TPC. Methods: A customer survey was developed seeking feedback on TPC. The pharmacy customers were invited to complete the survey in two local pharmacies in Germany. The survey and corresponding informed consent form were approved by the Ethics Committee. Results: In total, 178 pharmacy customers were enrolled (median age 41–50 years). From those, 37% agreed when asked whether they were generally interested in TPC. A total of 37% had the nearest pharmacy 5–15 min from their home. A total of 42% visited their pharmacy quarterly. A total of 36% used technical devices in median 1–2 h per days. A total of 33% classified their own digital skills at least as sufficient. A total of 59% would use their smartphone as a potential device for TPC. A total of 83% rated it as (slightly) important that the pharmacist providing TPC can be heard clearly. A total of 76% each (strongly) agreed that an argument for TPC would include limited mobility or pandemic/quarantine. A total of 33% (strongly) agreed that a key argument against TPC were technical requirements. A total of 75% considered situations of immobility to be the most important future perspective for TPC. Conclusions: Many pharmacy customers see TPC as an opportunity, e.g., in cases of limited mobility or during pandemic or quarantine. However, the use of appropriate technology can be a limiting factor. Full article

(This article belongs to the Section Pharmacy Practice and Practice-Based Research)

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21 pages, 1976 KB

Open AccessReview

Large Language Models for Drug-Related Adverse Events in Oncology Pharmacy: Detection, Grading, and Actioning

by Md Muntasir Zitu, Ashish Manne, Yuxi Zhu, Wasimul Bari Rahat and Samar Binkheder

Pharmacy 2025, 13(6), 176; https://doi.org/10.3390/pharmacy13060176 - 3 Dec 2025

Cited by 2 | Viewed by 1908

Abstract

Preventable medication harm in oncology is often driven by drug-related adverse events (AEs) that trigger order changes such as holds, dose reductions, delays, rechallenges, and enhanced monitoring. Much of the evidence needed to make these decisions lives in unstructured clinical texts, where large [...] Read more.

Preventable medication harm in oncology is often driven by drug-related adverse events (AEs) that trigger order changes such as holds, dose reductions, delays, rechallenges, and enhanced monitoring. Much of the evidence needed to make these decisions lives in unstructured clinical texts, where large language models (LLMs), a type of artificial intelligence (AI), now offer extraction and reasoning capabilities. In this narrative review, we synthesize empirical studies evaluating LLMs and related NLP systems applied to clinical text for oncology AEs, focusing on three decision-linked tasks: (i) AE detection from clinical documentation, (ii) Common Terminology Criteria for Adverse Events (CTCAE) grade assignment, and (iii) grade-aligned actions. We also consider how these findings can inform pharmacist-facing recommendations for order-level safety. We conducted a narrative review of English-language studies indexed in PubMed, Ovid MEDLINE, and Embase. Eligible studies used LLMs on clinical narratives and/or authoritative guidance as model inputs or reference standards; non-text modalities and non-empirical articles were excluded. Nineteen studies met inclusion criteria. LLMs showed the potential to detect oncology AEs from routine notes and often outperformed diagnosis codes for surveillance and cohort construction. CTCAE grading was feasible but less stable than detection; performance improved when outputs were constrained to CTCAE terms/grades, temporally anchored, and aggregated at the patient level. Direct evaluation of grade-aligned actions was uncommon; most studies reported proxies (e.g., steroid initiation or drug discontinuation) rather than formal grade-to-action correctness. While prospective, real-world impact reporting remained sparse, several studies quantified scale advantages and time savings, supporting an initial role as high-recall triage with pharmacist adjudication. Overall, the evidence supports near-term, pharmacist-in-the-loop use of AI for AE surveillance and review, with CTCAE-structured, citation-backed outputs delivered into the pharmacist’s electronic health record order-verification workspace as reviewable artifacts. Future work must standardize reporting and CTCAE/version usage, and measure grade-to-action correctness prospectively, to advance toward order-level decision support. Full article

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9 pages, 240 KB

Open AccessBrief Report

Cost Analysis of Multidose Drug Dispensing (MDD) System Implementation in a Community Pharmacy in Portugal

by Ana Reis, Ângelo Jesus and Maria Luisa Martín

Pharmacy 2025, 13(6), 175; https://doi.org/10.3390/pharmacy13060175 - 1 Dec 2025

Viewed by 812

Abstract

Background: Community pharmacies are increasingly delivering structured services to support chronic disease management, such as Multidose Drug Dispensing (MDD). This strategy can improve adherence and safety, but evidence of its economic feasibility in Portuguese pharmacies remains limited. Objective: To estimate the cost of [...] Read more.

Background: Community pharmacies are increasingly delivering structured services to support chronic disease management, such as Multidose Drug Dispensing (MDD). This strategy can improve adherence and safety, but evidence of its economic feasibility in Portuguese pharmacies remains limited. Objective: To estimate the cost of implementing and operating an MDD system in a community pharmacy, informing reimbursement models and policy. Methods: A micro-costing approach assessed fixed and variable expenses for serving polymedicated elderly patients. Costs were calculated in euros (2024/2025) and expressed per working day based on 253 annual preparation days. Results: First-year costs totaled €70,985.68, including €8184.00 for setup, €21,579.00 for supplies, and €41,222.68 for staff salaries. The daily operating cost was €280.58, with labour representing the major expense. A break-even analysis indicated sustainability with around 700 users at €10/month. Conclusion: Although requiring significant initial investment, MDD can become financially viable through scaling, workflow efficiency, and supportive reimbursement strategies. Full article

14 pages, 223 KB

Open AccessArticle

“But Will It Last?”: Examining How Pharmacy Staff Perceptions Influence Beliefs About the Sustainability of a Pharmacy-Based Intervention Targeting Older Adult Over-the-Counter (OTC) Medication Misuse

by Aaron M. Gilson, Katherine G. Moore, Stephanie M. Resendiz, Emily L. Hoffins, Shiying Mai, Jamie A. Stone and Michelle A. Chui

Pharmacy 2025, 13(6), 174; https://doi.org/10.3390/pharmacy13060174 - 1 Dec 2025

Viewed by 583

Abstract

Sustaining a well-designed healthcare intervention justifies the resources allocated during its conceptualization and implementation and maximizes its clinical benefits, but staff influences on sustainment have been studied insufficiently. This study evaluates the effects of pharmacy staff (i.e., pharmacists/technicians) perceptions about the sustainability of [...] Read more.

Sustaining a well-designed healthcare intervention justifies the resources allocated during its conceptualization and implementation and maximizes its clinical benefits, but staff influences on sustainment have been studied insufficiently. This study evaluates the effects of pharmacy staff (i.e., pharmacists/technicians) perceptions about the sustainability of Senior Safe^TM, a U.S. pharmacy-based intervention to reduce older adult over-the-counter (OTC) medication misuse. Three months after introducing Senior Safe into 67 pharmacies in a large Midwestern health-system, all pharmacy staff (N = 279) received a survey invitation. Fifty-nine pharmacists and 94 technicians completed the survey. Using logistic regression modeling for the 14 belief-based survey items, and staff roles (pharmacist or technician), the final factors significantly predicting staff views that Senior Safe was sustainable were as follows: perceiving Senior Safe as well-integrated into leadership operations (OR = 5.606, p < 0.001) and believing the intervention reduced OTC misuse (OR = 8.217, p < 0.001). Also, technicians were more confident than pharmacists about Senior Safe’s sustainment and its OTC misuse reduction success. Overall, an intervention’s sustainability relies on those using it. Since the principal predictor of maintaining Senior Safe was its perceived effectiveness, increasing staff buy-in and awareness of an intervention’s benefits may be central to its long-term viability. With an aging U.S. population, sustainable solutions to older adult medication misuse remain critical. Full article

11 pages, 213 KB

Open AccessArticle

Barriers and Opportunities in Cancer Pain Management: A Qualitative Study on Pharmacists’ Role

by Evangelos Aliferis, George Koulierakis, Christina Dalla and Tina Garani-Papadatos

Pharmacy 2025, 13(6), 173; https://doi.org/10.3390/pharmacy13060173 - 1 Dec 2025

Viewed by 752

Abstract

Introduction: Cancer pain remains a critical issue for patients’ quality of life, affecting their physiology, psychology, and social relationships. Despite the widely recognized role of pharmacists in pain management, their involvement in palliative care in Greece remains limited. This study focuses on exploring [...] Read more.

Introduction: Cancer pain remains a critical issue for patients’ quality of life, affecting their physiology, psychology, and social relationships. Despite the widely recognized role of pharmacists in pain management, their involvement in palliative care in Greece remains limited. This study focuses on exploring the perceptions and experiences of pharmacists regarding their role in cancer pain management, identifying barriers, required skills, and proposing strategies for their integration in the multidisciplinary team. Μaterials and Μethods: Qualitative research was conducted through semi-structured interviews with seven pharmacists in the Attica region. The interviews were recorded, transcribed, and thematically analyzed. Results: The analysis revealed four main themes: (1) limited access to medical records and challenges in pharmaceutical decision-making, (2) lack of institutional frameworks and a culture of collaboration, (3) need for specialized education and continuous training, and (4) understaffing and bureaucracy, faced by pharmacists. Discussion: This study highlights the underutilized role of pharmacists in cancer pain management in Greece. Barriers such as restricted access to patient records, weak interdisciplinary collaboration, insufficient training, and bureaucratic constraints limit their contribution. Structured frameworks and collaborative cultures can enhance pharmacists’ involvement, while education and continuous training are essential to strengthen their legitimacy within care teams. Digital tools can improve access to patient information and support evidence-based decisions. Conclusions: Pharmacists’ integration in the patient’s management team has significant benefits for the patient’s quality of life. Strengthening pharmacists’ involvement in cancer pain management requires the establishment of collaborations, continuous education, bureaucratic simplification, and the integration of digital tools. The development of practical resources, such as educational guides, can play a pivotal role in enhancing the quality of care provided. Full article

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13 pages, 1002 KB

Open AccessArticle

Capturing Value: How Health-System Specialty Pharmacies Define and Document Pharmacist Interventions

by Autumn D. Zuckerman, Karen C. Thomas, Erica Diamantides, Shannan Takhar, Rushabh Shah, Kelsi Conant, Thom Platt and Christian Rhudy

Pharmacy 2025, 13(6), 172; https://doi.org/10.3390/pharmacy13060172 - 26 Nov 2025

Viewed by 1472

Abstract

Standardized pharmacist intervention practices and documentation among health-system specialty pharmacies could improve understanding of the pharmacists’ role and value in this setting. This study describes current health-system specialty pharmacies’ intervention practices. A survey developed by a volunteer committee subgroup was distributed to two [...] Read more.

Standardized pharmacist intervention practices and documentation among health-system specialty pharmacies could improve understanding of the pharmacists’ role and value in this setting. This study describes current health-system specialty pharmacies’ intervention practices. A survey developed by a volunteer committee subgroup was distributed to two health-system specialty pharmacy group email distribution lists. The survey evaluated the types of tasks considered to be clinical or non-clinical interventions; who could perform interventions; where and how they were documented; data elements included in documentation; and how intervention data were classified, used, reviewed, and shared with internal or external stakeholders. Twenty-four institutions responded to the survey. Tasks within medication management, adverse drug events/monitoring, and education domains were more commonly considered clinical interventions; tasks in the health maintenance and coordination of care domains were more frequently considered non-clinical interventions or not considered to be interventions. Interventions were completed by pharmacists (at 100% of sites) and were mostly documented in the electronic health record (92%). Intervention data were primarily collected to meet accreditation purposes (96%) or for quality auditing and review (88%). No respondents shared intervention data with patients. Results demonstrate areas of alignment and variance in intervention definition and documentation among health-system specialty pharmacies. Full article

(This article belongs to the Section Pharmacy Practice and Practice-Based Research)

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13 pages, 243 KB

Open AccessArticle

Job Satisfaction Among Pharmacists Graduating from a University in Northern Sweden: A Comparative Analysis

by Maria Gustafsson, Helena Norberg and Sofia Mattsson

Pharmacy 2025, 13(6), 171; https://doi.org/10.3390/pharmacy13060171 - 22 Nov 2025

Viewed by 1200

Abstract

Job satisfaction plays a critical role in shaping professional outcomes, as it has been positively associated with enhanced performance and greater motivation. Conversely, insufficient job satisfaction may contribute to higher rates of staff turnover, professional burnout, and intentions to leave the profession. The [...] Read more.

Job satisfaction plays a critical role in shaping professional outcomes, as it has been positively associated with enhanced performance and greater motivation. Conversely, insufficient job satisfaction may contribute to higher rates of staff turnover, professional burnout, and intentions to leave the profession. The objective was to investigate job satisfaction among pharmacists educated at Umeå University in Sweden over time and to explore factors affecting job satisfaction. A survey was distributed to pharmacy graduates who had completed web-based pharmacy programs at Umeå University between 2019 and 2023. Questions regarding job satisfaction and factors related to it were included. The response rate was 38%. The results were compared with results from a previous investigation (graduation years 2015–2018) to enable comparisons over time. Compared to findings from the previous survey, job satisfaction was lower in the present study (76.4% vs. 91.4%, p = 0.004). Both greater opportunities for continuing professional development (CPD) and the perception that the knowledge and skills gained during education are beneficial in the current job were associated with high job satisfaction (OR: 5.360; 95% CI: 1.896–15.156 and OR: 3.983; 95% CI: 1.255–12.642, respectively). Understanding factors contributing to job satisfaction can help employers improve retention and work environment. Full article

32 pages, 950 KB

Open AccessReview

Medication Use by Older Adults with Frailty: A Scoping Review

by Rishabh Sharma, Tanaya Sharma, Brent McCready-Branch, Arshia Chauhan, Caitlin Carter, SooMin Park, Imra Hudani, Prapti Choudhuri and Tejal Patel

Pharmacy 2025, 13(6), 170; https://doi.org/10.3390/pharmacy13060170 - 21 Nov 2025

Viewed by 3112

Abstract

Frailty among older adults heightens their risk of negative health outcomes, and medication use plays a major role in this increased vulnerability. Various aspects of medication use elevate the risk of poor outcomes in individuals with frailty. The current scoping review was designed [...] Read more.

Frailty among older adults heightens their risk of negative health outcomes, and medication use plays a major role in this increased vulnerability. Various aspects of medication use elevate the risk of poor outcomes in individuals with frailty. The current scoping review was designed to explore medication use in older adults with frailty in primary care, focusing on the prevalence of potentially inappropriate medications (PIMs), polypharmacy, medication adherence, and their role in contributing to adverse drug events. This scoping review was conducted using the Arksey and O’Malley, supplemented by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Extension for Scoping Reviews (PRISMA-ScR) guidelines. A search of the literature was conducted from inception to November 2023 in Ovid EMBASE, PubMed (MEDLINE), Scopus, EBSCOhost CINAHL, and Ovid International Pharmaceutical Abstracts. Studies which met the eligibility criteria included older adults with frailty (≥65 years) living at home, defined frailty criteria, and assessment of medication use. Out of the 4726 studies screened, 223 were included, conducted across 39 countries. Frailty prevalence varied widely from 0.9% to 89.2%. Polypharmacy (5–9 medications) and hyper-polypharmacy (≥10 medications) were notably more common among individuals with frailty, with polypharmacy rates ranging from 1.3% to 96.4%. Twelve studies reported PIM prevalence among individuals with varying levels of frailty, ranging from 2.4% to 95.9%. This scoping review highlights the challenges and complexities involved in understanding the relationship between medication use and frailty in older adults. Full article

(This article belongs to the Section Pharmacy Practice and Practice-Based Research)

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36 pages, 4070 KB

Open AccessEditor’s ChoiceReview

Monoclonal Antibodies as a Breakthrough in Personalised Leukaemia Therapy: What Pharmacists and Doctors Should Know

by Anastasiia Ryzhuk, Sergiy M. Kovalenko, Marine Georgiyants, Kateryna Vysotska and Victoriya Georgiyants

Pharmacy 2025, 13(6), 169; https://doi.org/10.3390/pharmacy13060169 - 20 Nov 2025

Viewed by 2278

Abstract

Monoclonal antibodies (mAbs) are an important medical innovation in modern medicine. They are an effective therapy for several subtypes of leukaemia but may have undesirable effects, which may be minimised through the provision of interdisciplinary care including a pharmacist. The goals of this [...] Read more.

Monoclonal antibodies (mAbs) are an important medical innovation in modern medicine. They are an effective therapy for several subtypes of leukaemia but may have undesirable effects, which may be minimised through the provision of interdisciplinary care including a pharmacist. The goals of this narrative review were twofold: first, to summarise the literature on the side effects of mAbs and the challenges of their preparation, and to provide recommendations for the safe preparation of mAb drug formulations for clinicians. Second, to suggest clinical roles for pharmacists to improve patient safety and clinical outcomes for leukaemia patients receiving mAb therapy. The review covers data from 178 scientific and official sources of information on the types of targeted immunobiological drugs for the treatment of various types of leukaemia. The results are a detailed description of the possible side effects from mAb therapy and a list of suggested actions that can be taken to prevent them. Pharmaceutical aspects of the use of mAbs, such as pharmacoeconomics, compounding and stability, are also discussed. The discussion is organised according to the current classification of leukaemia. The drugs considered include blinatumomab, inotuzumab ozogamicin, gemtuzumab ozogamicin, rituximab, ofatumumab, obinutuzumab, and alemtuzumab. The review offers a comprehensive resource to equip pharmacists and other clinicians to optimise mAb therapy and promote the safe use of these novel therapies. Full article

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12 pages, 831 KB

Open AccessArticle

Effects of Modifying Supportive Care Medications in Combination Therapy with Pertuzumab, Trastuzumab, and Taxane Anticancer Drugs

by Mina Takagi, Shinichiro Maeda, Makiko Maeda, Yasushi Fujio and Sachiko Hirobe

Pharmacy 2025, 13(6), 168; https://doi.org/10.3390/pharmacy13060168 - 17 Nov 2025

Viewed by 1045

Abstract

Chemotherapy for breast cancer includes pertuzumab and trastuzumab regimens with docetaxel (PHD) or paclitaxel (PHP). Current approaches for using supportive care drugs to manage the side effects of PHD and PHP are unclear. Here, we investigated the occurrence of side effects before and [...] Read more.

Chemotherapy for breast cancer includes pertuzumab and trastuzumab regimens with docetaxel (PHD) or paclitaxel (PHP). Current approaches for using supportive care drugs to manage the side effects of PHD and PHP are unclear. Here, we investigated the occurrence of side effects before and after supportive care medications were modified by discontinuing antipyretic analgesics. We retrospectively analyzed adverse events that occurred within 24 h of treating 76 patients with PHD or PHP. The frequencies of adverse effects in the groups before and after modification did not differ significantly (45.5% [15/33] and 44.2% [19/43], respectively). Severity also did not significantly differ between the groups. Therefore, discontinuing antipyretic analgesics as supportive care drugs had little effect on the frequency of side effects. Symptoms of feeling hot, pyrexic, and flushed were frequent, and their severity increased in the group after the support drugs were modified. Discontinuation of supportive care medications, including antipyretic analgesics, might affect the severity of certain symptoms and lead to the development of side effects that require medical intervention. Overall, our findings indicate the need to consider premedication with antipyretic analgesics, including further analysis of the risk factors that can predict symptoms. Full article

(This article belongs to the Section Pharmacy Practice and Practice-Based Research)

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14 pages, 536 KB

Open AccessArticle

Pharmacist Intervention Models in Drug–Drug Interaction Management in Prescribed Pharmacotherapy

by Ivana Samardžić, Ivana Marinović, Iva Marović, Nikolina Kuča and Vesna Bačić Vrca

Pharmacy 2025, 13(6), 167; https://doi.org/10.3390/pharmacy13060167 - 17 Nov 2025

Viewed by 1660

Abstract

Drug–drug interactions (DDIs) are one of the most common problems related to drug administration which represent a risk for patient safety. Considering their position in the healthcare system, pharmacists should be more proactively involved in DDI management. The paper shows representation of DDI [...] Read more.

Drug–drug interactions (DDIs) are one of the most common problems related to drug administration which represent a risk for patient safety. Considering their position in the healthcare system, pharmacists should be more proactively involved in DDI management. The paper shows representation of DDI intervention models in each DDI category. This research enrolled outpatients prescribed pharmacotherapies from 40 randomly selected community pharmacies. DDIs were analyzed using Lexicomp^® Lexi-InteractTM Online (Lexi-Comp, Inc., Hudson, NY, USA) software. Clinical pharmacists’ panel, according to the necessary interventions, determined an independent model of pharmacist interventions (category 1) and models that require cooperation with physicians (category 2) for DDI management. In total, 4107 patients were enrolled in the study. Mean patient age was 67.5; they were mostly women (56.5%) and had on average of 3.4 diagnosis and 5.5 prescription drugs. Overall, 14,175 potential clinically significant DDIs were identified: 83.3% of C, 15.4% of D, and 1.3% of X category. At least one potential DDI was found in 78.6% of patients. Models of pharmacist DDI interventions in collaboration with a physician (category 2) were more prevalent than independent models (category 1): 57.5% vs. 42.5% in C category DDIs, 97.8% vs. 2.2% in D category, and 100% vs. 0% in category X DDIs. This research aimed to gain an insight into the distribution of interventions in DDI management models between physicians and pharmacists, which can contribute to more efficient pharmaceutical care and visibility. Full article

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15 pages, 386 KB

Open AccessArticle

Experiences Reported by People with Epilepsy During Antiseizure Medication Shortages in the UK: A Cross-Sectional Survey

by Eric Amankona Abrefa Kyeremaa, Tom Shillito, Caroline Smith, Charlotte Lawthom, Sion Scott and David Wright

Pharmacy 2025, 13(6), 166; https://doi.org/10.3390/pharmacy13060166 - 10 Nov 2025

Viewed by 1769

Abstract

(1) Background: Medication shortages have become increasingly common in the UK. However, there is limited evidence regarding the experiences of people with epilepsy and their caregivers during these shortages. The aim of this study is to explore the extent and impact of ASM [...] Read more.

(1) Background: Medication shortages have become increasingly common in the UK. However, there is limited evidence regarding the experiences of people with epilepsy and their caregivers during these shortages. The aim of this study is to explore the extent and impact of ASM shortages on people with epilepsy and their caregivers across the UK. (2) Methods: A cross-sectional online survey was distributed between January and April, 2024 by epilepsy charities. Participants included people with epilepsy and caregivers. The survey collected demographic information, types of ASM respondents were prescribed, experiences of shortages, and the impact of shortages. Data were analysed descriptively, and subgroup analyses were conducted by medication type. (3) Results: A total of 1549 responded, of whom 1312 were people with epilepsy and their carers who were included in the analysis with a mean age of 43 years. A total of 941 respondents (71.7%) reported difficulty obtaining their prescribed ASM in the past year. Shortages were most frequently reported for sodium valproate (60.8%), lamotrigine (65.2%), carbamazepine (92.6%), clobazam (82.6%), topiramate (81.5%), zonisamide (74.0%), levetiracetam (62.8%), lacosamide (71.0%), and brivaracetam (70.5%). A total of 529 (40.4%) of the participants reported that stress and/or anxiety caused by medication shortages was associated with recurrent seizures. We did not ask whether patients missed medications because of these difficulties. (4) Conclusions: ASM shortages are a widespread issue for people with epilepsy in the UK, leading to treatment disruptions and psychological distress. Addressing supply change limitations and identifying effective approaches to preventing the substitution of ASMs brands by clinicians may potentially reduce this problem. Full article

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14 pages, 225 KB

Open AccessArticle

Bedside Medication Management: Pharmacy Technicians Managing Patient Medication Supply to Improve Nursing Productivity and Patient Safety

by Tom W. Simpson, Duncan S. Mckenzie, Rosina G. Guastella and Michael J. Ryan

Pharmacy 2025, 13(6), 165; https://doi.org/10.3390/pharmacy13060165 - 7 Nov 2025

Viewed by 1486

Abstract

Audits of medication charts conducted by Royal Hobart Hospital Pharmacy revealed that dose omission was the most common medication error experienced by patients. Investigation of these errors also found that nurses spend significant time organising medication for inpatients. To address the issues contributing [...] Read more.

Audits of medication charts conducted by Royal Hobart Hospital Pharmacy revealed that dose omission was the most common medication error experienced by patients. Investigation of these errors also found that nurses spend significant time organising medication for inpatients. To address the issues contributing to these problems, an alternative model of medication management was implemented and tested. This model of bedside medication management involves medication supply managed by ward pharmacy technicians who review charts daily for changes to medicines and obtain the medicines needed for each patient. Outcomes on two intervention wards showed that the model, combined with technician involvement in controlled medicines stock management, resulted in 29.78 h of nursing time released to patient care per 20-bed ward per week, for an investment of 22.28 h of ward pharmacy technician time; a 75% reduction in delayed doses; a 44% reduction in missed doses; and an average decrease of two hours in the turnaround time for supply of inpatient medication. Introducing bedside medication management and controlled medicines stock management activities can release 1.34 h of nursing time to patient care for every hour of ward pharmacy technician time (at a lower hourly salary cost), decrease dose delays and omissions, and improve patient safety. Full article

13 pages, 502 KB

Open AccessArticle

The Spectrum of Clinical Pharmacy Services in a Non-University Hospital—A Comprehensive Characterization Including a Risk Assessment for Drug-Related Problems and Adverse Drug Reactions

by Olaf Zube, Wiebke Schlüter, Johanna Dicken, Jan Hensen and Thilo Bertsche

Pharmacy 2025, 13(6), 164; https://doi.org/10.3390/pharmacy13060164 - 6 Nov 2025

Viewed by 984

Abstract

Background: Clinical pharmacy services (CPS) have been shown to confer significant advantages in patient care. It remains to be clarified how CPS resources are allocated across routine care settings. It remains to be clarified which recommendations are made to resolve the drug-related problems [...] Read more.

Background: Clinical pharmacy services (CPS) have been shown to confer significant advantages in patient care. It remains to be clarified how CPS resources are allocated across routine care settings. It remains to be clarified which recommendations are made to resolve the drug-related problems (DRP) identified by CPS and which adverse drug reactions (ADR) actually arise from the identified DRP. Methods: Following positive ethical approval, patient chart analyses, evaluation of pharmacy documentation on CPS and pharmacist interviews were performed to characterize CPS at all medical departments of the Bundeswehr Hospital Hamburg. We developed and pre-tested instruments for standardization: A Standard Operating Procedure (SOP) for the practical exercise and documentation of CPS by the pharmacists performing them, a standardized form (checklist) for retrospective data collection as part of this study, and a standardized questionnaire for conducting the pharmacist interviews including a risk assessment according to the NCC-MERP score. Results: In total, 1000 CPS were documented in 504 patients (mean age: 69.95 years; 229 female) on 16,705 treatment days. A total of 66.87% CPS was initiated when pharmacists participated in ward rounds. In all CPS, “Indications” was the topic addressed most frequently (37.70%). “Agents for obstructive respiratory diseases” was the most frequently involved drug class (11.32%). The most frequent processing time per CPS was 16–30 min (48.61%). The number of CPS ranged from 0.36/100 treatment days in dermatology to 12.47 in oncology. Severity of 358 DRP was classified “very severe” (5.03%), “severe” (42.74%), “moderate” (34.36%), “low” (15.08%), “very low” (1.40%), or “without impact” (1.40%). The probability of DRP occurrence was classified as “high” in 13.13% and “very high” in 3.35%. In 15.36% of the DRP, an ADR actually occurred. In 504 patients, 932 specific recommendations were forwarded to solve the DRP identified during CPS. Of those, 53.97% were implemented. Conclusions: In almost all CPS, a considerable number of DRP with serious clinical consequences were identified. Half of the forwarded recommendations were implemented. Full article

(This article belongs to the Section Pharmacy Practice and Practice-Based Research)

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21 pages, 712 KB

Open AccessArticle

Assessment of Job Satisfaction and Intention to Quit Job Among Pharmacists in Saudi Arabia

by Ashwaq Alharthi, Maha Aleiban, Abdulrahman Alwhaibi, Moureq Alotaibi, Yousef Almutairi and Sultan Alghadeer

Pharmacy 2025, 13(6), 163; https://doi.org/10.3390/pharmacy13060163 - 5 Nov 2025

Viewed by 1665

Abstract

Background/Objectives: Job satisfaction is an essential element for organizational functions. Working entities would not effectively operate without employee contentment. This study aimed to determine the level of job satisfaction among pharmacists and investigate its correlation with demographic variables and professional personal experience. Methods: [...] Read more.

Background/Objectives: Job satisfaction is an essential element for organizational functions. Working entities would not effectively operate without employee contentment. This study aimed to determine the level of job satisfaction among pharmacists and investigate its correlation with demographic variables and professional personal experience. Methods: A cross-sectional online survey targeting registered pharmacists in Saudi Arabia was conducted from September to November 2024 using an IRB-approved structured questionnaire adapted from validated instruments. Reliability and validity were confirmed (Cronbach’s α = 0.8), and a target sample of 380 was calculated to ensure representativeness. Data were analyzed using descriptive statistics, chi-squared tests, and univariate and multivariate logistic regression analyses utilizing SPSS v28, with significance set at p < 0.05. Results: A total of 330 pharmacists responded to the survey, representing 86.8% of the calculated sample size. Of those, 57% were male and 68.5% were staffing pharmacists. More than half of participants had professional experience of ≤5 years (57.3%), while 31.8% had 5 to 15 years of experience. Approximately 60% of participants worked in shift systems and reported dissatisfaction with their pay (70%) and lack of benefits (66.7%). Of all participants, only 26.4% confirmed satisfaction with their job and no intention to quit, while 23% clearly reported job dissatisfaction and an intention to quit; the rest of the participants were undecided (50.6%). Significant correlations were found between job satisfaction and variables such as education, current position, organization type, monthly income, and professional experience. Additionally, most of the items assessing professional personal experience such as working in a shift system, working as a team member, gaining financial benefits, and having accomplishments or growth opportunities at work were significantly correlated with job satisfaction. Opportunities for professional development, promotion, and a positive work environment were also frequently selected as factors contributing to job satisfaction (60.6%, 75.2% and 75.5%, respectively). Interestingly, motivation showed minimal impact on participants’ opinions regarding job satisfaction and decisions over whether to quit their jobs. Finally, occupation and age were found to significantly influence work environments, promotions, and opportunities, which consequently impact participants’ satisfaction towards their jobs. Conclusions: Our findings indicate that Saudi pharmacists experience low-to-moderate job dissatisfaction, with a significant percentage considering quitting form their jobs. Improving monetary rewards, recognition, and career advancement opportunities could improve job satisfaction and retention in this crucial workforce. Full article

(This article belongs to the Special Issue Pharmacy Workflow Optimization: Strategies for Enhancing Efficiency and Patient Satisfaction)

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12 pages, 228 KB

Open AccessPerspective

Healthcare Practice Post COVID-19 Impacts: Will 21st Century Pharmacists Become Global, Agile, Collaborative and Curated?

by Maree Donna Simpson, Jaimy Jose and Jennifer L. Cox

Pharmacy 2025, 13(6), 162; https://doi.org/10.3390/pharmacy13060162 - 3 Nov 2025

Viewed by 964

Abstract

“Those that fail to learn from history are doomed to repeat it.” Winston Churchill. In recent times, globally, approximately three pandemics and thousands of natural disasters and political upheavals have been recorded. In most cases, tens to hundreds of thousands of [...] Read more.

“Those that fail to learn from history are doomed to repeat it.” Winston Churchill. In recent times, globally, approximately three pandemics and thousands of natural disasters and political upheavals have been recorded. In most cases, tens to hundreds of thousands of people have died as a result, whether from droughts, famines, floods, earthquakes, tsunamis, wildfires, landslides, cyclones, typhoons, hurricanes, extreme heat, emerging or resurgent diseases or longer-term issues such as sustainability, climate change and/or global warming. Whilst many accommodations may have been made to cope with these, we propose that pharmacy education and professional practice benefit from learning from the past, from collaboration globally to manage the hectic and uncertain times that result from these disruptions and from curation and evaluation of these initiatives for ongoing and/or future use. Full article

(This article belongs to the Collection New Insights into Pharmacy Teaching and Learning during COVID-19)

12 pages, 234 KB

Open AccessArticle

Socioeconomic Determinants of Career Intention in Pharmacy Students in Vietnam

by Quang Ngoc Phan, Oanh Thi Kim Nguyen, Hoa Thi Tran, Ngoc Bao Dang and Nam Hoang Tran

Pharmacy 2025, 13(6), 161; https://doi.org/10.3390/pharmacy13060161 - 2 Nov 2025

Viewed by 1535

Abstract

Background: The pharmacy workforce in Vietnam is rapidly evolving, but little is known about how gender and socioeconomic factors shape career intentions and sector preferences of students. Understanding these determinants is essential for healthcare workforce planning. Objective: To investigate how gender and socioeconomic [...] Read more.

Background: The pharmacy workforce in Vietnam is rapidly evolving, but little is known about how gender and socioeconomic factors shape career intentions and sector preferences of students. Understanding these determinants is essential for healthcare workforce planning. Objective: To investigate how gender and socioeconomic determinants influence intention of pharmacy students to pursue a career and their preferred sector in Vietnam. Methods: A cross-sectional survey was conducted among 462 students from 2nd to 5th year at a Vietnamese university. Demographic data, socioeconomic background, and career intentions were analyzed using chi-squared tests, multinomial logistic regression, and binary logistic regression. Results: Of 462 respondents, 71.9% intended to pursue a pharmacy career, 2.6% reported no, while 25.5% were unsure. Gender differences were evident but did not reach statistical significance (p = 0.083). Female students were more likely to choose clinical, hospital pharmacy or regulation, whereas male students showed higher preference for community, industry and academia. Binary logistic regression revealed that urban origin (OR = 1.34, 95% CI = 1.01–1.78, p = 0.041) and family encouragement (OR = 2.53, 95% CI = 1.60–3.99, p < 0.001) significantly predicted career intention, while gender and income were non-significant. Conclusions: Family encouragement and urban upbringing influence pharmacy career pursuit, while gender may shape sectoral preferences. Policies should address gender equity and enhance support for students from rural or disadvantaged backgrounds. Full article

(This article belongs to the Special Issue Women's Special Issue Series: Pharmacy and Pharmacists)

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9 pages, 720 KB

Open AccessCase Report

Extemporaneous Preparation and Effectiveness of Low-Dose Naltrexone for the Treatment of Uremic Pruritus: A Literature Review and Case Report

by Dhakrit Rungkitwattanakul, Michelle Brooks, Simeon Adesina, Sanaa Belrhiti, Weerachai Chaijamorn, Taniya Charoensareerat, Uzoamaka Nwaogwugwu and Constance Mere

Pharmacy 2025, 13(6), 160; https://doi.org/10.3390/pharmacy13060160 - 1 Nov 2025

Cited by 1 | Viewed by 2157

Abstract

Background: Uremic pruritus is one of the most debilitating complications among patients with end-stage kidney disease (ESKD) receiving hemodialysis. For patients who are refractory to traditional therapies (topical analgesics, antihistamines, or gabapentinoids), the use of low-dose naltrexone can be an option where difelikefalin [...] Read more.

Background: Uremic pruritus is one of the most debilitating complications among patients with end-stage kidney disease (ESKD) receiving hemodialysis. For patients who are refractory to traditional therapies (topical analgesics, antihistamines, or gabapentinoids), the use of low-dose naltrexone can be an option where difelikefalin is not available. Case report: In our case report, we present a case of a female patient who developed intractable uremic pruritus despite the adequate trials of traditional therapies. The patient was initiated with low-dose naltrexone of 5 mg daily. Uremic symptoms improved within 3 days of naltrexone initiation. The side effects were tolerated. Conclusion: Low-dose naltrexone provided symptomatic improvement in individuals with severe uremic pruritus when difelikefalin was inaccessible. While limited to a single case, this report highlights the potential role of naltrexone and underscores the need for further research to establish its safety and efficacy. Full article

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14 pages, 776 KB

Open AccessArticle

Hospital Pharmacists’ Perspectives on Documenting and Classifying Pharmaceutical Interventions: A Nationwide Validation Study in Portugal

by Sara Machado, Fátima Falcão and Afonso Miguel Cavaco

Pharmacy 2025, 13(6), 159; https://doi.org/10.3390/pharmacy13060159 - 1 Nov 2025

Viewed by 1489

Abstract

Pharmacist interventions (PIs) are central to optimising pharmacotherapy, preventing drug-related problems, and improving patient outcomes. In Portugal, the absence of a validated tool to consistently document and classify PIs limits data comparability and service development. Given these gaps, this study aimed to describe [...] Read more.

Pharmacist interventions (PIs) are central to optimising pharmacotherapy, preventing drug-related problems, and improving patient outcomes. In Portugal, the absence of a validated tool to consistently document and classify PIs limits data comparability and service development. Given these gaps, this study aimed to describe hospital pharmacists’ attitudes towards PI documentation and classification, following confirmatory factor analysis (CFA) of a survey instrument, and to provide a comprehensive overview of current practices and behaviours in hospital settings across Portugal. An online questionnaire, previously validated, was distributed online to all hospital pharmacists registered with the Portuguese Pharmaceutical Society (October–December 2024). Sociodemographic data and the cognitive and behavioural domains of pharmacists’ attitudinal model were analysed descriptively, and CFA tested the three-factor structure (Process, Outcome, Satisfaction) of the attitudinal affective domain. Of 1848 pharmacists, 260 responded (14%). Respondents reported performing a mean of 49 PIs/month (SD = 196), although many never recorded (28.8%), classified (56.2%), or analysed (52.3%) interventions. Only 2.7% declared to use a validated classification framework. The CFA supported the structural coherence of the Process factor but revealed some overlapping between Process and Outcome and instability in the Satisfaction factor. The nationwide scope and application of CFA provided partial support for the hypothesised model and highlighted areas for refinement, including revision of Satisfaction items and reconsideration of Process and Outcome as overlapping constructs. Findings highlight strong professional commitment to PIs but persistent barriers, including less clear procedures and satisfaction, underscoring the need for a unified, standardised national system to support consistent recording, classification, and evaluation. Full article

(This article belongs to the Section Pharmacy Practice and Practice-Based Research)

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24 pages, 1933 KB

Open AccessReview

Barriers and Facilitators of Using MyDispense from the Student Perspective: A Systematic Review

by Owen Collins, Ruth McCarthy and Laura J. Sahm

Pharmacy 2025, 13(6), 158; https://doi.org/10.3390/pharmacy13060158 - 1 Nov 2025

Viewed by 1395

Abstract

MyDispense is a high-fidelity, low-stakes community pharmacy simulation, allowing students to practice dispensing skills. A systematic review was conducted to identify students’ perceptions regarding barriers and facilitators of MyDispense in pharmacy education. PubMed, CINAHL, and EMBASE databases were searched from 2015 to 2025 [...] Read more.

MyDispense is a high-fidelity, low-stakes community pharmacy simulation, allowing students to practice dispensing skills. A systematic review was conducted to identify students’ perceptions regarding barriers and facilitators of MyDispense in pharmacy education. PubMed, CINAHL, and EMBASE databases were searched from 2015 to 2025 in January 2025 using combined keywords, proximity searching and Boolean operators. Studies investigating MyDispense and gathering students’ perceptions were included. Record screening was conducted by two independent reviewers (OC and LS). Any identified records from database searching and hand searching of included study reference lists were imported to Rayyan and subjected to independent review. Conflicts were resolved through a third party (RMcC), and discussions were held until consensus was reached. Fifteen studies were included in this review. Seven studies were conducted in USA, six in Asia, one in UK, and one in Australia. All studies utilised purposive sampling. Sample sizes ranged from 33 to 322 students. All studies included surveys to gather student perceptions. Other data collection methods included semi-structured interviews and focus group discussions for students to further elaborate on survey responses. Identified facilitators were mapped to four overarching themes; “Develops competency”, “User-Friendliness”, “Engaging Learning Experience” and “Safe Learning Environment.” Key barriers were encompassed to three themes: “Learning Curve”, “IT issues” and “Limited Realism and Applications”. Barriers included (i) the learning curve of the platform, (ii) technical issues, and (iii) limited realism. Facilitators included perceptions of (i) improved dispensing and counselling skills and a deeper understanding of pharmacy legislation, (ii) accessibility, interactivity of the learning environment and (iii) immediate feedback. Synthesis of the evidence in this review identified students’ perceptions of barriers and facilitators of MyDispense in pharmacy education. This may serve as a guide to educators considering the adoption of MyDispense into their curricula. Full article

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25 pages, 1028 KB

Open AccessReview

Community Pharmacist Prescribing: Roles and Competencies—A Systematic Review and Implications

by Stephanie Clemens, Lea Eisl-Raudaschl, Johanna Pachmayr and Olaf Rose

Pharmacy 2025, 13(6), 157; https://doi.org/10.3390/pharmacy13060157 - 1 Nov 2025

Viewed by 2519

Abstract

Increasing healthcare demands and physician shortages have prompted many countries to expand clinical responsibilities of pharmacists. Although Canada, the UK, and the US have implemented pharmacist prescribing, other nations lag behind. This review compares international roles, identifies inferred competencies, and explores implications for [...] Read more.

Increasing healthcare demands and physician shortages have prompted many countries to expand clinical responsibilities of pharmacists. Although Canada, the UK, and the US have implemented pharmacist prescribing, other nations lag behind. This review compares international roles, identifies inferred competencies, and explores implications for role expansion. A systematic search of MEDLINE, CINAHL, and the Cochrane Library was conducted using the PICO framework; studies were appraised with Critical Appraisal Skills Programme (CASP) checklists, and interrater reliability assessed via Cohen’s Kappa. Data from 23 studies were thematically synthesized following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. Four themes emerged: (1) expanding clinical and public health roles and pharmacists’ self-perceived readiness; (2) regulatory frameworks defining legal authority, qualifications, and temporary pandemic exemptions; (3) inferred competencies, including micro-skills (patient assessment, guideline application) and macro-capabilities (clinical judgment, accountability, reflective practice); and (4) contextual barriers such as training gaps, limited funding, unclear legal provisions, and workflow challenges. Implementation implications were synthesized and included training, funding, acceptance, and integration. Evidence indicates pharmacist prescribing is safe and patient-centered when supported by regulation, structured training, and systemic integration. Insights from established models can guide incremental implementation, optimizing medication management, enhancing healthcare access, and promoting equitable care. Full article

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13 pages, 553 KB

Open AccessReview

How Have Entrustable Professional Activities (EPAs) Been Implemented in Pharmacy Education? A Scoping Review

by Luiz Claudio Oliveira Alves de Souza, Luciana Flavia de Almeida Romani and Marina Guimaraes Lima

Pharmacy 2025, 13(6), 156; https://doi.org/10.3390/pharmacy13060156 - 1 Nov 2025

Viewed by 1391

Abstract

Entrustable Professional Activities (EPAs) are units of professional practice entrusted to learners once they have attained the required competencies to perform them. This scoping review described how Entrustable Professional Activities (EPAs) have been implemented in pharmacy education. MEDLINE (PubMed), Scopus, and Google Scholar [...] Read more.

Entrustable Professional Activities (EPAs) are units of professional practice entrusted to learners once they have attained the required competencies to perform them. This scoping review described how Entrustable Professional Activities (EPAs) have been implemented in pharmacy education. MEDLINE (PubMed), Scopus, and Google Scholar were searched (on 8 July 2025) to identify relevant literature from 2016 to 2025. Studies that describe EPAs implemented in pharmacy programs, assess the perspectives on EPAs implemented, or evaluate student performance on EPAs were included. Studies that did not assess actual experience of EPAs’ implementation were excluded. The data were described narratively and through frequencies and tables. Twenty-four studies were included in the review. Most studies pointed out that the EPAs’ framework has been adopted mostly in practice experiences, but with a few experiences in course activities. The most frequent approach to assess student performance on EPAs was direct practice observation. Student performance on EPAs improved after participating in educational activities. From the perspectives of students, preceptors, and faculty members, EPAs facilitated student assessment of competencies; however, there are challenges in their implementation, such as heavy workload. The findings of this review can inform faculty members and health professionals who intend to implement EPAs’ framework. Full article

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