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Biomolecules, Volume 14, Issue 10
October 2024 - 142 articles
Cover Story: This paper delves into the mechanistic role of glycosphingolipids (GSLs) in cardiovascular disease, emphasizing their influence on inflammation, energy metabolism, and key signaling pathways that are crucial for heart function. GSLs interact with membrane microdomains, modulate mitochondrial dynamics, and impact lipid homeostasis, driving processes that contribute to heart failure. Through human and animal model studies, this work uncovers how disruptions in GSL metabolism are linked to oxidative stress, cardiac remodeling, and hypertrophy. These findings position GSLs as promising biomarkers and therapeutic targets for advancing cardiovascular treatment strategies. View this paper
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Biomolecules - ISSN 2218-273X