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Biomolecules, Volume 13, Issue 12
December 2023 - 128 articles
Cover Story: Basic physicochemical parameters of fibroblast growth factor 21 (FGF 21) in electrolytes were determined for the first time using theoretical and experimental techniques. Molecular dynamics calculations revealed that FGF 21 possesses a globular shape and forms dimers. The dependence of the nominal charge of the molecules on pH was determined, allowing the identification of the point of zero charge (5.3). FGF 21 tends to irreversibly adsorb onto positively charged surfaces (poly(diallyldimethylammonium chloride) covered silica), while its adsorption onto negatively charged substrates was negligible. The studied protein was found to be non-toxic for the examined cell lines. One can postulate that the FGF 21-based complex may have a positive impact on cell adhesion and proliferation. View this paper
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Biomolecules - ISSN 2218-273X