Table of Contents
Metabolites, Volume 9, Issue 2 (February 2019)
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Cover Story (view full-size image) Cancer metabolic reprogramming has been reported as one of the “hallmarks of cancer”, providing [...] Read more. Cancer metabolic reprogramming has been reported as one of the “hallmarks of cancer”, providing proliferating cancer cells with bioenergetic and biosynthetic advantages. Additionally, tumorigenesis has been largely associated with increased oxidant levels, further counteracted by the upregulation of antioxidant systems. For instance, the balance between intracellular ROS and antioxidant needs is closely dependent on metabolic pathways, generating crosstalk between metabolism and redox status. In this paper, we applied a multidisciplinary approach to investigate the interplay among metabolic, redox, and oncogenic alterations in papillary thyroid carcinoma cell lines. The results highlighted changes in energetic pathways and in the redox balance, confirming the pivotal role of these two hallmarks of cancer in the papillary thyroid carcinoma biology. View this paper.