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Metabolites 2019, 9(2), 25; https://doi.org/10.3390/metabo9020025

The OMICs Window into Nonalcoholic Fatty Liver Disease (NAFLD)

Division of Gastroenterology, Department of Medical Specialties, University of Modena and Reggio Emilia, 41124 Modena, Italy
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Received: 31 December 2018 / Revised: 26 January 2019 / Accepted: 30 January 2019 / Published: 1 February 2019
(This article belongs to the Special Issue Metabolism and Metabolomics of Liver in Health and Disease)
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Abstract

Nonalcoholic fatty liver disease (NAFLD) is a common cause of hepatic abnormalities worldwide. Nonalcoholic steatohepatitis (NASH) is part of the spectrum of NAFLD and leads to progressive liver disease, such as cirrhosis and hepatocellular carcinoma. In NASH patient, fibrosis represents the major predictor of liver-related mortality; therefore, it is important to have an early and accurate diagnosis of NASH. The current gold standard for the diagnosis of NASH is still liver biopsy. The development of biomarkers able to predict disease severity, prognosis, as well as response to therapy without the need for a biopsy is the focus of most up-to-date genomic, transcriptomic, proteomic, and metabolomic research. In the future, patients might be diagnosed and treated according to their molecular signatures. In this short review, we discuss how information from genomics, proteomics, and metabolomics contribute to the understanding of NAFLD pathogenesis. View Full-Text
Keywords: nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; Fibrosis; Liver biopsy; Genomics; Metabolomics; Proteomics; Transcriptomics nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; Fibrosis; Liver biopsy; Genomics; Metabolomics; Proteomics; Transcriptomics
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Carulli, L.; Zanca, G.; Schepis, F.; Villa, E. The OMICs Window into Nonalcoholic Fatty Liver Disease (NAFLD). Metabolites 2019, 9, 25.

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