Next Article in Journal
Modulation of Polar Lipid Profiles in Chlorella sp. in Response to Nutrient Limitation
Previous Article in Journal
Effects of Sowing Season on Agronomic Traits and Fatty Acid Metabolic Profiling in Three Brassica napus L. Cultivars
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessArticle
Metabolites 2019, 9(2), 38; https://doi.org/10.3390/metabo9020038

Feed Restriction Reveals Distinct Serum Metabolome Profiles in Chickens Divergent in Feed Efficiency Traits

1
Institute of Animal Nutrition and Functional Plant Compounds, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, 1210 Vienna, Austria
2
Agri-Food and Biosciences Institute, Agriculture Branch, Hillsborough, Northern Ireland BT26 6DR, UK
3
Teagasc, Pig Development Department, Animal & Grassland Research & Innovation Centre, Moorepark, Co. Cork, P61 C996 Fermoy, Ireland
4
Institute for Global Food Security, Queen’s University Belfast, Belfast BT7 1NN, UK
*
Author to whom correspondence should be addressed.
Received: 29 January 2019 / Revised: 20 February 2019 / Accepted: 20 February 2019 / Published: 25 February 2019
  |  
PDF [863 KB, uploaded 26 February 2019]
  |     |  

Abstract

Restrictive feeding influences systemic metabolism of nutrients; however, this impact has not been evaluated in chickens of diverging feed efficiency. This study investigated the effect of ad libitum versus restrictive feeding (85% of ad libitum) on the serum metabolome and white blood cell composition in chickens of diverging residual feed intake (RFI; metric for feed efficiency). Blood samples were collected between days 33 and 37 post-hatch. While serum glucose was similar, serum uric acid and cholesterol were indicative of the nutritional status and chicken’s RFI, respectively. Feed restriction and RFI rank caused distinct serum metabolome profiles, whereby restrictive feeding also increased the blood lymphocyte proportion. Most importantly, 10 amino acids were associated with RFI rank in birds, whereas restrictive feeding affected almost all detected lysophosphatidylcholines, with 3 being higher and 6 being lower in restrictively compared to ad libitum fed chickens. As indicated by relevance networking, isoleucine, lysine, valine, histidine, and ornithine were the most discriminant for high RFI, whereas 3 biogenic amines (carnosine, putrescine, and spermidine) and 3 diacyl-glycerophospholipids (38:4, 38:5, and 40:5) positively correlated with feed intake and body weight gain, respectively. Only for taurine, feed intake mostly explained the RFI-associated variation, whereas for most metabolites, other host physiological factors played a greater role for the RFI-associated differences, and was potentially related to insulin-signaling, phospholipase A2, and arachidonic acid metabolism. Alterations in the hepatic synthesis of long-chain fatty acids and the need for precursors for gluconeogenesis due to varying energy demand may explain the marked differences in serum metabolite profiles in ad libitum and restrictively fed birds. View Full-Text
Keywords: broiler chicken; serum metabolome; amino acids; lipids; feed intake level; residual feed intake broiler chicken; serum metabolome; amino acids; lipids; feed intake level; residual feed intake
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Metzler-Zebeli, B.U.; Siegerstetter, S.-C.; Magowan, E.; Lawlor, P.G.; O’Connell, N.E.; Zebeli, Q. Feed Restriction Reveals Distinct Serum Metabolome Profiles in Chickens Divergent in Feed Efficiency Traits. Metabolites 2019, 9, 38.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Metabolites EISSN 2218-1989 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top