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Metabolites 2019, 9(2), 34; https://doi.org/10.3390/metabo9020034

Metabolomics Approaches for the Diagnosis and Understanding of Kidney Diseases

1
School of Veterinary and Life Sciences, Murdoch University, 90 South Street, Perth 6150, Australia
2
Separation Science and Metabolomics Laboratory, Murdoch University, 90 South Street, Perth 6150, Australia
3
Metabolomics Australia, Murdoch University Node, Murdoch University, 90 South Street, Perth 6150, Australia
*
Author to whom correspondence should be addressed.
Received: 10 October 2018 / Revised: 29 January 2019 / Accepted: 5 February 2019 / Published: 14 February 2019
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PDF [747 KB, uploaded 14 February 2019]
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Abstract

Diseases of the kidney are difficult to diagnose and treat. This review summarises the definition, cause, epidemiology and treatment of some of these diseases including chronic kidney disease, diabetic nephropathy, acute kidney injury, kidney cancer, kidney transplantation and polycystic kidney diseases. Numerous studies have adopted a metabolomics approach to uncover new small molecule biomarkers of kidney diseases to improve specificity and sensitivity of diagnosis and to uncover biochemical mechanisms that may elucidate the cause and progression of these diseases. This work includes a description of mass spectrometry-based metabolomics approaches, including some of the currently available tools, and emphasises findings from metabolomics studies of kidney diseases. We have included a varied selection of studies (disease, model, sample number, analytical platform) and focused on metabolites which were commonly reported as discriminating features between kidney disease and a control. These metabolites are likely to be robust indicators of kidney disease processes, and therefore potential biomarkers, warranting further investigation. View Full-Text
Keywords: acute kidney injury; chronic kidney disease; diabetic nephropathy; kidney cancer; kidney disease; kidney transplantation; polycystic kidney disease; biomarker; chromatography; mass spectrometry; metabolomics acute kidney injury; chronic kidney disease; diabetic nephropathy; kidney cancer; kidney disease; kidney transplantation; polycystic kidney disease; biomarker; chromatography; mass spectrometry; metabolomics
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Abbiss, H.; Maker, G.L.; Trengove, R.D. Metabolomics Approaches for the Diagnosis and Understanding of Kidney Diseases. Metabolites 2019, 9, 34.

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