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Metabolites, Volume 15, Issue 7

July 2025 - 73 articles

Cover Story: This study investigated seminal vesicle (SV-S9) metabolism of doping agents (stanozolol, LGD-4033, GW1516, trimetazidine, anastrozole) compared to liver S9 fractions. LC-HRAM MS analysis revealed minimal SV-S9 activity: LGD-4033, GW1516 and trimetazidine showed minor metabolites, while stanozolol and anastrozole remained unchanged. Digital PCR detected CYP2D6, CYP2E1 and CYP2C9 transcripts in SV-S9, but no enzymatic activity. Key hepatic enzymes (CYP3A4, CYP1A2) were absent. Findings suggest that seminal vesicles play a negligible role in xenobiotic metabolism, with implications for doping control interpretations. View this paper
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Articles (73)

  • Article
  • Open Access
1,166 Views
17 Pages

Enhanced Mitochondrial Dynamics and Reactive Oxygen Species Levels with Reduced Antioxidant Defenses in Human Epicardial Adipose Tissue

  • Ana Burgeiro,
  • Diana Santos,
  • Ana Catarina R. G. Fonseca,
  • Inês Baldeiras,
  • Ermelindo C. Leal,
  • João Moura,
  • João Costa-Nunes,
  • Patrícia Monteiro Seraphim,
  • Aryane Oliveira and
  • António Canotilho
  • + 5 authors

Background/Objectives: Epicardial adipose tissue (EAT) is metabolically active and is in dynamic crosstalk with the surrounding cardiomyocytes, modulating their function and metabolism. Oxidative stress is a key contributor to cell death and cardiac...

  • Review
  • Open Access
1,009 Views
12 Pages

The appearance rate of nutrients into systemic circulation affects hormones like insulin and through that efficiency of growth. This also affects mineral requirements critical for metabolism, notably phosphate (P), magnesium (Mg), and potassium (K)....

  • Review
  • Open Access
3 Citations
3,603 Views
31 Pages

The Role of Probiotics, Prebiotics, Synbiotics, and Postbiotics in Livestock and Poultry Gut Health: A Review

  • Taojing Yue,
  • Yanan Lu,
  • Wenli Ding,
  • Bowen Xu,
  • Cai Zhang,
  • Lei Li,
  • Fuchun Jian and
  • Shucheng Huang

Background: The gut health of livestock and poultry is of utmost importance as it significantly impacts their growth performance, disease resistance, and product quality. With the increasing restrictions on antibiotic use in animal husbandry, probiot...

  • Review
  • Open Access
1,247 Views
19 Pages

The Complexity of Oxidative Stress in Human Age-Related Diseases—A Review

  • Alicja Płóciniczak,
  • Ewelina Bukowska-Olech and
  • Ewa Wysocka

The aging process is a complex and dynamic phenomenon influenced by genetic, environmental, and biochemical factors. One of the key contributors to aging and age-related diseases is oxidative stress, resulting from an imbalance between the generation...

  • Article
  • Open Access
688 Views
15 Pages

The Effects of Dietary Supplementation of Chestnut Tannic Acid on the Growth Performance, Gut Morphology and Microbiota of Weaned Piglets

  • Jinzhou Zhang,
  • Yuting Zhang,
  • Yuya Wang,
  • Yanwei Li,
  • Dongyang Liu,
  • Hongbing Xie,
  • Yongqiang Wang,
  • Meinan Chang,
  • Liping Guo and
  • Zhiguo Miao

Background/Objectives: This study investigated the effects of chestnut tannic acid (TA) on the growth performance, the expression of tight junction proteins and the composition of the gut microbiota of weaned piglets, which could provide novel insigh...

  • Article
  • Open Access
662 Views
21 Pages

EM Dipeptide Enhances Milk Protein Secretion: Evidence from Integrated Metabolomic and Transcriptomic Analysis

  • Yuqing Liu,
  • Yuhao Yan,
  • Runjun Yang,
  • Xiaohui Li,
  • Chuang Zhai,
  • Xuan Wu,
  • Xibi Fang and
  • Boqun Liu

Background/Objectives: Breast milk provides essential nutrition and immune protection to support infant growth and development. However, insufficient breast milk remains a serious issue, and bioactive peptides represent a potential strategy to promot...

  • Article
  • Open Access
641 Views
14 Pages

Preliminary Study to Understand the Role of Gut Microbiota in Coronary Slow Flow Phenomenon (CSFP)

  • Tayfun Gurol,
  • Tayyip Karaman,
  • Yesim Gurol,
  • Osman Ugur Sezerman and
  • Sinem Oktem Okullu

Background/Objectives: Coronary slow flow phenomenon (CSFP) is a cardiovascular condition characterized by delayed passage of contrast medium through the coronary arteries, predominantly affecting young male smokers admitted with acute coronary syndr...

  • Article
  • Open Access
627 Views
15 Pages

Cross-Sectional and Longitudinal Assessment of Sociodemographic and Lifestyle Determinants of Metabolic Syndrome and Hypertriglyceridemic Waist Phenotypes in 139,634 Spanish Workers

  • Joan Obrador de Hevia,
  • Ángel Arturo López-González,
  • José Ignacio Ramírez-Manent,
  • Carla Busquets-Cortés,
  • Pedro Juan Tárraga López and
  • Pere Riutord-Sbert

Objective: The objective of this study was to analyze the prevalence and key sociodemographic and lifestyle determinants of metabolic syndrome (MetS) and the hypertriglyceridemic waist (HTGW) phenotype in a large occupational cohort. Background: Meta...

  • Article
  • Open Access
902 Views
15 Pages

Pharmacometabolomics Study of Sulfamethoxazole and Trimethoprim in Kidney Transplant Recipients: Real-World Metabolism and Urinary Excretion

  • Marieke A. J. Hof,
  • Hessel de Haan,
  • Stepan Stepanovic,
  • Stephan J. L. Bakker,
  • Eelko Hak,
  • Gérard Hopfgartner,
  • Frank Klont and
  • TransplantLines Investigators

Background/Objectives: The increased use of antibiotics is raising concerns about environmental contamination and antibiotic resistance, exemplified by the case of cotrimoxazole, a widely prescribed combination of sulfamethoxazole and trimethoprim. A...

  • Article
  • Open Access
940 Views
17 Pages

Aerobic Exercise Delays Age-Related Sarcopenia in Mice via Alleviating Imbalance in Mitochondrial Quality Control

  • Danlin Zhu,
  • Lian Wang,
  • Haoyang Gao,
  • Ze Wang,
  • Ke Li,
  • Xiaotong Ma,
  • Linlin Zhao and
  • Weihua Xiao

Background: Sarcopenia is a syndrome associated with aging, characterized by a progressive decline in skeletal muscle mass and function. Its onset compromises the health and longevity of older adults by increasing susceptibility to falls, fractures,...

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Metabolites - ISSN 2218-1989