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Metabolites, Volume 13, Issue 9

September 2023 - 65 articles

Cover Story: Cytomegalovirus (CMV) can cause morbidity and mortality following stem cell transplantation. Several metabolites have been linked to this infection, but these metabolites were treated as individual variables rather than pathway-linked entities. In this study, we used WGCNA, a pathway-resolved data-driven method, to explore the relationship between metabolites and CMV infection. We observed groups of metabolites associated with CMV infection, but also to related clinical factors including graft-versus-host disease (GvHD) and the pre-transplantation conditioning regimen. These results may have implications for future metabolomics research in this patient cohort. To facilitate this, we include an interactive HTML file of the study results to allow researchers to easily explore the data and form new hypotheses for future studies. View this paper
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Articles (65)

  • Article
  • Open Access
4 Citations
2,669 Views
17 Pages

17 September 2023

The lung has raised significant concerns because of its radiosensitivity. Radiation-induced lung injury (RILI) has a serious impact on the quality of patients’ lives and limits the effect of radiotherapy on chest tumors. In clinical practice, e...

  • Article
  • Open Access
3,159 Views
11 Pages

Short-Term Standard Diet Consumption Prior to the Oral Fat Tolerance Test Modulates the Postprandial Triglyceride Response

  • Fulya Balaban Yucesan,
  • Eda Nur Demir,
  • Serap Ozer Yaman,
  • Asım Orem,
  • Busra Dokuz Murat and
  • Busra Bilgin

17 September 2023

We hypothesized that the consumption of a 3-day standard diet (SD) prior to the oral fat tolerance test (OFTT), used to evaluate postprandial lipemia, may counteract the undesirable effects of individual dietary habits on the test results. The OFTT w...

  • Article
  • Open Access
13 Citations
2,169 Views
19 Pages

Comparison of Metabolites and Main Nutritional Components between Uncooked and Cooked Purple Rice

  • Wenfei Gu,
  • Yuehong Peng,
  • Ruizhi Wang,
  • Runnan Wang,
  • Han Wu,
  • Jinyan Zhu,
  • Xinhua Ni and
  • Qiangqiang Xiong

15 September 2023

Cooking can lead to varying degrees of nutrient loss in purple rice. For this investigation, two varieties of purple rice (YZN1 and YZ6) were chosen as the focal points to explore the metabolites associated with rice nutrition post cooking using nont...

  • Review
  • Open Access
16 Citations
3,585 Views
21 Pages

15 September 2023

Diabetes mellitus, particularly type 2 diabetes mellitus (T2DM), imposes a significant global burden with adverse clinical outcomes and escalating healthcare expenditures. Early identification of biomarkers can facilitate better screening, earlier di...

  • Review
  • Open Access
14 Citations
4,814 Views
16 Pages

15 September 2023

Obesity is a multifactorial disorder that is remarkably heterogeneous. It presents itself in a variety of phenotypes that can be metabolically unhealthy or healthy, associate with no or multiple metabolic risk factors, gain extreme body weight (super...

  • Brief Report
  • Open Access
7 Citations
2,062 Views
9 Pages

Genistein Suppresses IL-6 and MMP-13 to Attenuate Osteoarthritis in Obese Diabetic Mice

  • Janelle Lopez,
  • Layla Al-Nakkash,
  • Tom L. Broderick,
  • Monica Castro,
  • Brielle Tobin and
  • Jeffrey H. Plochocki

14 September 2023

Type 2 diabetes mellitus and osteoarthritis (OA) often present as comorbidities. We examined the role of plasma IL-6, chondrocyte MMP-13, and col10a expression in the development of OA in obese diabetic mice. We further investigated dietary genistein...

  • Article
  • Open Access
20 Citations
5,762 Views
23 Pages

Nutritional, Antioxidant, Antimicrobial, and Anticholinesterase Properties of Phyllanthus emblica: A Study Supported by Spectroscopic and Computational Investigations

  • Mohamed A. A. Orabi,
  • Aso Hameed Hasan,
  • Sameh F. AbouZid,
  • Dalia El Amir,
  • Mona H. Hetta,
  • Ahmed Abdullah Al Awadh,
  • Omaish Salman Alqahtani,
  • Tsutomu Hatano and
  • Mohamed A. El-Shanawany

14 September 2023

Dietary fruits and vegetables play a vital role as food and drugs and are the main sources of antioxidant defences against degenerative diseases, such as brain dysfunctions, cardiovascular diseases, immune system deteriorations, and cancers, brought...

  • Article
  • Open Access
8 Citations
2,046 Views
16 Pages

Stable Isotope Dilution Analysis (SIDA) to Determine Metabolites of Furan and 2-Methylfuran in Human Urine Samples: A Pilot Study

  • Jonathan Isaak Kremer,
  • Dorothea Karlstetter,
  • Verena Kirsch,
  • Daniel Bohlen,
  • Carina Klier,
  • Jan Rotermund,
  • Hannah Thomas,
  • Lukas Lang,
  • Hanna Becker and
  • Tamara Bakuradze
  • + 2 authors

14 September 2023

Furan and 2-methylfuran (2-MF) are food contaminants that are classified as potentially carcinogenic to humans. The main source of exposure for adults via food is coffee consumption. Furan and 2-MF are volatile, which complicates exposure assessment...

  • Article
  • Open Access
7 Citations
2,245 Views
18 Pages

Sex Modifies the Impact of Type 2 Diabetes Mellitus on the Murine Whole Brain Metabolome

  • Jennifer E. Norman,
  • Saivageethi Nuthikattu,
  • Dragan Milenkovic and
  • Amparo C. Villablanca

14 September 2023

Type 2 diabetes mellitus (T2DM) leads to the development of cardiovascular diseases, cognitive impairment, and dementia. There are sex differences in the presentation of T2DM and its associated complications. We sought to determine the impact of sex...

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Metabolites - ISSN 2218-1989